Uncommonly this may lead to symptoms such as breast enlargement, production of milk or … A study undertaken to determine the cause of the elevated drug levels in these 2 deaths provides inconclusive results.
U.S. Food and Drug Administration "Zyprexa Relprevv (olanzapine pamoate): Drug Safety Communication - FDA review of study sheds light on two deaths associated with the injectable schizophrenia drug. Very common adverse effects of olanzapine, occurring more than 10%, include: Weight gain (dose-dependent). Moreover, many AATPs, including olanzapine, interfere with HTR2C function, which led researchers to suggest that it was olanzapine’s block of HTR2C function that was causing the metabolic syndrome. See below for … Lilly, Eli and Company, Indianapolis, IN. Adolescents may be more likely to experience weight gain, and hyperlipidemia (a condition where there are high levels of lipids in the blood). Disorder Involving Personality Changes 3. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.Things to remember when you fill your prescription.WebMD does not provide medical advice, diagnosis or treatment. Disturbance Of Attention 5. You'll want to share with your doctor of all the medications you take including prescription medication, herbals, vitamins, and any over-the-counter medications. Available from: URL: http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHu" ([2015 Mar 23]):2. This mouse model was then used to investigate how olanzapine causes weight gain.

Always feeling tired? Head Pain 10. Other side effects include: abnormal gait, back pain, constipation, fever, orthostatic hypotension, weight gain, myoclonus, and personality disorder. Verywell Mind uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. It's important to note that there are also some unique side effects that teenagers may experience with Zyprexa, so be sure to review these with your doctor.

Lorcaserin blocked olanzapine’s overeating, weight gain, and metabolic syndrome side effects. The average length of duration for the trials was 10 weeks with the cause of death in the majority of cases, though not all, reported as either cardiovascular (e.g., heart failure, sudden death) or infectious (e.g., pneumonia) in nature. In addition, Zyprexa can increase blood sugar levels, putting a person at risk for developing diabetes.All three of these factors combined—weight gain, high blood sugar, and high cholesterol—can increase the patient's risk of heart disease, which is why it's important to review an exercise and nutritional plan with your doctor while on Zyprexa. Bladder pain bloody or cloudy urine bruising burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings chest pain difficult or labored breathing difficult, burning, or painful urination dizziness excessive muscle tone frequent urge to urinate headache Ⓒ 2020 About, Inc. (Dotdash) — All rights reserved Weight Gain; INFREQUENT side effects. However, it induces serious metabolic side effects. FDA.

Verywell Mind uses cookies to provide you with a great user experience. As reported in a 3-23-2015 drug safety communication issued by the US Food and Drug Administration, a study in animals found much of the drug level increases could have occurred after death, but the possibility that the deaths were caused by a rapid, but delayed entry of the drug in to the bloodstream could not be ruled out.
High blood prolactin (milk producing hormone) level (hyperprolactinaemia). To test this, they fed mice olanzapine and treated the mice with an FDA-approved weight-loss drug called lorcaserin, which activates HTR2C. Marcia Purse is a mental health writer and bipolar disorder advocate who brings strong research skills and personal experiences to her writing. You may report them to the The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. AATPs can be effective treatments for disorders such as schizophrenia, bipolar disorder, and depression. "Product Information. The researchers then asked: if olanzapine’s metabolic side effects are mediated by its blockage of HTR2C function, then could the side effects be alleviated by activating HTR2C?