Search for other works by this author on: A., Vostrov, S. N., Shevchenko, A.

The present study compares the antimicrobial effects of azithromycin and roxithromycin on Most macrolides introduced over the past decade exhibit an enhanced ability to penetrate and persist in peripheral tissues, irrespective of high (e.g.

Molecular dynamics simulations informed by membrane lipidomics reveal the structure–interaction relationship of polymyxins with the lipid A-based outer membrane of (b) Roxithromycin profile (Correspondence address.

10 The respective values of F, V 0 and V 1 are presented in the Table. For this reason, comparative pharmacodynamics of macrolides might be better based on tissue rather than plasma pharmacokinetics.

Based on azithromycin and roxithromycin pharmacokinetic parameters, F, V 0 and V 1 were calculated as described elsewhere.

Early therapeutic monitoring of β-lactams and associated therapy outcomes in critically ill patients Ery-Tab (Erythromycin) works well to treat a variety of bacterial infections, but check for drug interactions before taking it. To calculate the steady-state concentrations of azithromycin in human tonsils, pharmacokinetic data from a 500 mg single dose study \[\mathit{C}(\mathit{t})\ {=}\ \mathit{B}\ exp\ ({-}\mathit{k}_{el}\ \mathit{t})\ {-}\ \mathit{A}\ exp\ ({-}\mathit{k}_{in}\ \mathit{t}),\] \[\mathit{T}_{lag}\ {=}\ log\ (\mathit{A}/\mathit{B})/(\mathit{k}_{in}\ {-}\ \mathit{k}_{el})\] European Journal of Clinical Microbiology and Infectious Diseases© 2002 The British Society for Antimicrobial Chemotherapy

Tel: +7-095-332-3435; Fax: +7-095-332-3335; E-mail: This study was supported by a grant from Roerig, a division of Pfizer Pharmaceuticals.Lode, H., Boeckh, M., Schaberg, T., Borner, K. & Koeppe, P. (1993).

Pharmacology. After overnight incubation at 37°C in a 5% COThe suitability of ciprofloxacin as a marker for the macrolides was verified by simultaneous simulation of roxithromycin and ciprofloxacin with the pharmacokinetic parameters of roxithromycin. The pharmacokinetic parameters of azithromycin and roxithromycin were produced in the model in triplicate using ciprofloxacin. azithromycin, dirithromycin) plasma concentrations.Similarities or differences in efficacy between these two macrolides might better correlate with their tissue concentrations than their plasma concentrations.

Search for other works by this author on: Roxithromycin is a prescription medication indicated to treat certain types of bacterial infections, such as pharyngitis, sinusitis, bronchitis and pneumonia. Clinical isolates of The simulated pharmacokinetic profiles reflected steady-state tonsillar concentrations of the macrolides expected after a third dose of azithromycin 500 mg od and after a sixth dose of roxithromycin 150 mg bd.Assuming linear pharmacokinetics and using the superimposition principle, steady-state tonsillar concentrations of azithromycin were calculated based on the parameters of equation 1Steady-state concentrations of roxithromycin in homogenized tonsils have been reported in humans after twice daily administration of 150 mg for 3 daysA slightly modified version of a previously described dynamic modelPhysically, the model was represented by three connected flasks: one containing fresh trypticase soy broth with 10% pooled horse serum; the second, subcompartment 0, containing the same broth; and the third, compartment 1, containing the broth plus a bacterial culture (Figure 2The ability of the dynamic model to simulate the required pharmacokinetic profiles of azithromycin and roxithromycin was tested using ciprofloxacin, because levels of this drug can be measured easily with good reliability and sensitivity. Unable to load your delegates due to an error In Firsov, A., Tichonov, V., Kuleshov, S. & Stratchunsky, L. (1993). Reasons for this may be the relatively extensive uptake and release of the drug from the tissues.

Please enable it to take advantage of the complete set of features! Epub 2012 Jul 4. Search for other works by this author on: A., Nazarov, A. D. & Chernykh, V. M. (1989). 2017 Apr;27(4):164-167. doi: 10.1097/FPC.0000000000000270.Chem Cent J. To verify the suitability of the use of ciprofloxacin as a marker for the macrolides, parallel determinations of ciprofloxacin and roxithromycin were also performed when 10-fold greater concentrations of roxithromycin and ciprofloxacin with pharmacokinetic parameters of roxithromycin were simulated simultaneously.Ciprofloxacin concentrations were assayed by highperformance liquid chromatography (HPLC) with a precolumn (50 × 4.6 mm) and on a column (250 × 4.6 mm) of Silasorb 5 CRoxithromycin concentrations were also determined by HPLC using a precolumn (50 × 4.6 mm) and on a column (250 × 4 mm) with Nucleosil 10 CIn each experiment, 0.1 mL samples were withdrawn from bacteria-containing media in the central compartment (the third flask) throughout the observation period, initially every hour, then every 3 h, and again hourly during the last 6–7 h. These samples were subjected to serial 10-fold dilutions with chilled, sterile 0.9% NaCl and were plated in duplicate on trypticase soy agar supplemented with 10% pooled horse serum. Azithromycin penetration into sinus mucosa and tonsillar tissue.

This site needs JavaScript to work properly. Azithromycin (Zithromax) and clarithromycin (Biaxin) are macrolide antibiotics that are used in the treatment of community-acquired respiratory tract infections, particularly pneumonia.