Selegiline is rapidly distributed throughout the body, the apparent volume of distribution being 500 1 after an intravenous 10 mg dose. Check with your doctor right away if you have pain when swallowing, pain in the mouth, redness, swelling, or sores in your mouth while receiving this medicine.

Find out what health conditions may be a health risk when taken with Selegiline Oral Treatment of overdose with non-selective MAOIs is symptomatic and supportive. Select your Country. ​Emsam (selegiline transdermal system) is a monoamine oxidase inhibitor (MAOI) indicated for the treatment of adults with major depressive disorder (MDD) [see ​Clinical Studies (14)​]. Our science team must pass long technical science tests, difficult logical reasoning and reading comprehension tests. Take the...Parkinson's disease is a slowly progressive neurological disease characterized by a fixed inexpressive face, a tremor at rest, slowing of voluntary movements, a gait with short accelerating steps, peculiar posture and muscle weakness, caused by degeneration of an area of the brain called the basal ganglia, and by low production of the neurotransmitter dopamine. Copy the URL below and paste it into your RSS Reader application. Each capsule, for oral administration contains 5 mg of selegiline hydrochloride. Selegiline is a lipophilic, slightly basic compound which quickly penetrates into tissues, also into brain. One case of hypertensive crisis has been reported in a patient taking the recommended doses of selegiline and a sympathomimetic medication (ephedrine). Contraindications. These foods, beverages, and medicines include:Also, for at least 2 weeks after you stop taking this medicine, these foods, beverages, and other medicines may continue to react with selegiline if it was taken in doses higher than those usually used for Parkinson's disease.

Selegiline is contraindicated in patients with a known hypersensitivity to this drug. (See Drug Interactions .) This is important because many of the symptoms of Parkinson’s are caused by reduced levels of dopamine as cell death spreads throughout dopamine-related parts of the brain [Relatedly, it is believed that increased dopamine levels may compensate for the loss of dopamine neurons in PD, which may be why dopamine-enhancing drugs such as selegiline have been reported to improve the movement impairments characteristic of Parkinson’s disease (especially slowness of movement, or For example, selegiline was reported to improve motor symptoms in 292 patients with early Parkinson’s disease (double-blind randomized controlled trial) [Similarly, in a double-blind randomized controlled trial of 157 Parkinson’s disease patients, selegiline (10 mg/day) delayed the need for In addition to increasing dopamine levels, some evidence suggests that selegiline may also block the effects of MPTP, a neurotoxic compound that causes permanent symptoms of Parkinson’s [Another common medical use of selegiline is to treat depression.It is generally believed that selegiline acts as an antidepressant due to its reported ability to increase the levels of dopamine, serotonin, andA meta-analysis of 5 different clinical studies reported that selegiline helped alleviate several key symptoms of major depression, including [Another meta-analysis of 5 short-term trials (with a combined total of 352 subjects) concluded that selegiline significantly improved several different symptoms of major depressive disorder [According to one double-blind randomized controlled trial of 322 subjects with majorSelegiline has also been reported to improve symptoms of apathy in 4 patients following severe brain injury [Nonetheless, while not all of the evidence out there unanimously supports selegiline’s effectiveness as an antidepressant, the fact that it has been officially approved by the FDA for the treatment of depression indicates that the overall weight of the evidence is considered by medical experts to be quite strong.Occasionally, doctors will prescribe medications to help treat conditions that fall outside of the official uses approved by the FDA – also known as “As always, however, always remember that the decision to use medications in this way can only be made by a licensed medical professional.Although selegiline has not been officially FDA-approved for this purpose, it is not uncommon for doctors to prescribe this medication in order to help improve or control the symptoms of ADHD.The main rationale for using selegiline in this way stems from its potential to increase dopamine levels throughout the brain. Some people who have used this medicine had unusual changes in their behavior. Do not stop taking this medicine without first checking with your doctor. Four strengths of almond-shaped tablets are available in different sizes and different shades of yellow: This contraindication is often extended to other opioids. Since selegiline has similar mechanisms, the idea is that giving smokers small amounts of selegiline could make them less dependent on nicotine for these effects [However, so far the only evidence on this is for people with specific genetic variants.For example, selegiline-treated smokers with a specific nicotine-sensitive genotype (One possible explanation for this is that selegiline blocks the breakdown of nicotine by theA handful of animal studies suggest that selegiline may have potential in preventing or controlling seizures.For example, selegiline has been reported to prevent seizures in mice with epilepsy [A similar effect has also been reported in a rat model of epilepsy [Nonetheless, it goes without saying that studies in human patients would be needed to see if this effect holds up.While selegiline has been approved for safety and efficacy when used as directed, like any other drug it still has its share of potential side-effects that it is important to be aware of.Keep in mind that the best way to minimize your overall risk of experiencing side-effects is to use this medication only as directed by your doctor, and to keep him or her fully informed about any other medications you are taking, other health conditions, and other relevant factors that may impact your treatment.High doses (> 10 mg/day) of selegiline have been reported to prevent the MAO-A enzyme from breaking down Tyramine is a naturally-occurring amino acid found in fermented meat, soy products, and aged cheese.