Absorption is at least 50%, based on urinary excretion of Clopidogrel metabolites.Clopidogrel can be administered with or without food. Possible factors contributing to this outcome were the dose of Clopidogrel, the concomitant administration of aspirin and the late initiation of therapy following shunt palliation. This tool may not cover all possible drug interactions. You may be asked to stop taking clopidogrel a week before any planned surgery, as it may prolong any bleeding. Decreased active metabolite exposure and diminished inhibition of platelet aggregation were observed in the poor metabolizers as compared to the other groups.Clopidogrel was found to have no effect on fertility of male and female rats treated prior to pairing and throughout gestation at oral doses up to 400 mg/kg per day (52 times the recommended human dose on a mg/mThe CURE study included 12,562 patients with ACS without ST-elevation (UA or NSTEMI) and presenting within 24 hours of onset of the most recent episode of chest pain or symptoms consistent with ischemia. ▪️ If you're going to have any surgery, including dental surgery, it's important that your doctor or dentist knows that you're taking clopidogrel. Upper respiratory tract infection (8.7%) Chest pain (8.3%) Headache (7.6%) Flulike syndrome (7.5%) Arthralgia (6%) Pain (6%) Dizziness (6%) Diarrhea (4.5%) Rash (4.2%) Rhinitis (4.2%) Depression (3.6%) Urinary tract infection (3.1%) All pregnancies have a background risk of birth defects, loss, or other adverse outcomes. This could increase the risk of getting a bleeding in the stomach. In CAPRIE, which compared Clopidogrel to aspirin, pruritus was more frequently reported in those taking Clopidogrel. There isn’t enough data to assess the safety of using clopidogrel during pregnancy. These doses, corresponding to 65 and 78 times the recommended daily human dose, respectively, on a mg/mThere are no data on the presence of Clopidogrel in human milk or the effects on milk production. This could increase the risk of getting a bleeding in the stomach.Clopidogrel should not be used in pregnancy. The clinically important adverse reactions observed in trials comparing Clopidogrel plus aspirin to placebo plus aspirin and trials comparing Clopidogrel alone to aspirin alone are discussed below.In CURE, Clopidogrel use with aspirin was associated with an increase in major bleeding (primarily gastrointestinal and at puncture sites) compared to placebo with aspirin (see Table 1). Drugs A-Z Pill Identifier Supplements Symptom Checker Diseases Dictionary Media These are not all the possible side effects of Clopidogrel tablets. No adverse effects on breastfed infants have been observed with maternal Clopidogrel use during lactation in a small number of postmarketing cases. Cimetidine — use an alternative H2 antagonist. It is important to consult a doctor promptly if you experience any unexplained bruising or unusual bleeding, for example nose bleeds or bleeding from the bottom., especially if you are feeling generally unwell, tired, have fever or signs of infection. All subjects were treated with aspirin 75 to 162 mg daily. Copyright © 2018 by RxList Inc. RxList does not provide medical advice, diagnosis or treatment. Find out what health conditions may be a health risk when taken with Clopidogrel Oral Who should not take Clopidogrel?
Check with your physician if you have any of the following: Conditions: increased risk of bleeding due to clotting disorder When possible, discontinue Clopidogrel 5 to 7 days prior to labor, delivery, or neuraxial blockade.The available data from published case reports over two decades of postmarketing use have not identified an association with Clopidogrel use in pregnancy and major birth defects, miscarriage, or adverse fetal outcomes.Embryo-fetal developmental toxicology studies were performed in pregnant rats and rabbits with doses up to 500 and 300 mg/kg/day, respectively, administered during organogenesis. ▪️ People taking other medicines that increase the risk of bleeding for example aspirin, warfarin or heparin. You may be able to find more information about this and similar content at piano.io The following conditions are contraindicated with this drug. You must check to make sure that it is safe for you to take clopidogrel with all of your drugs and health problems. A UK registered practising pharmacist with over 20 years' experience, Rita is a member of the Please check with a physician if you have health questions or concerns. It is important to consult a doctor promptly if you experience any unexplained bruising or unusual bleeding, for example nose bleeds or bleeding from the bottom., especially if you are feeling generally unwell, tired, have fever or signs of infection. The metabolism of Clopidogrel can also be impaired by drugs that inhibit CYP2C19, such as omeprazole or esomeprazole. Available for Android and iOS devices. Avoid neuraxial blockade during Clopidogrel use because of the risk of spinal hematoma. ▪️ People taking other medicines that increase the risk of bleeding for example aspirin, warfarin or heparin. Deaths not easily attributable to nonvascular causes were all classified as vascular.The curves showing the overall event rate are shown in Figure 7. Drugs which when taken concurrently with clopidogrel may reduce the antiplatelet effect include: Antifungals (voriconazole, fluconazole, ketoconazole) —avoid concurrent use. Netdoctor participates in various affiliate marketing programs, which means we may get paid commissions on editorially chosen products purchased through our links to retailer sites.
Check with your physician if you have any of the following: Conditions: increased risk of bleeding due to clotting disorder When possible, discontinue Clopidogrel 5 to 7 days prior to labor, delivery, or neuraxial blockade.The available data from published case reports over two decades of postmarketing use have not identified an association with Clopidogrel use in pregnancy and major birth defects, miscarriage, or adverse fetal outcomes.Embryo-fetal developmental toxicology studies were performed in pregnant rats and rabbits with doses up to 500 and 300 mg/kg/day, respectively, administered during organogenesis. ▪️ People taking other medicines that increase the risk of bleeding for example aspirin, warfarin or heparin. You may be able to find more information about this and similar content at piano.io The following conditions are contraindicated with this drug. You must check to make sure that it is safe for you to take clopidogrel with all of your drugs and health problems. A UK registered practising pharmacist with over 20 years' experience, Rita is a member of the Please check with a physician if you have health questions or concerns. It is important to consult a doctor promptly if you experience any unexplained bruising or unusual bleeding, for example nose bleeds or bleeding from the bottom., especially if you are feeling generally unwell, tired, have fever or signs of infection. The metabolism of Clopidogrel can also be impaired by drugs that inhibit CYP2C19, such as omeprazole or esomeprazole. Available for Android and iOS devices. Avoid neuraxial blockade during Clopidogrel use because of the risk of spinal hematoma. ▪️ People taking other medicines that increase the risk of bleeding for example aspirin, warfarin or heparin. Deaths not easily attributable to nonvascular causes were all classified as vascular.The curves showing the overall event rate are shown in Figure 7. Drugs which when taken concurrently with clopidogrel may reduce the antiplatelet effect include: Antifungals (voriconazole, fluconazole, ketoconazole) —avoid concurrent use. Netdoctor participates in various affiliate marketing programs, which means we may get paid commissions on editorially chosen products purchased through our links to retailer sites.