Concomitant use of alcohol, extensive periods of standing, prolonged or intense exercise, and exposure to heat can also precipitate orthostatic hypotension and should be minimized. Therapy with peripheral alpha-1 blockers should be administered cautiously in patients with or predisposed to hypotensive or syncopal episodes. ... it causes practically no orthostatic hypotension (in contrast to other α1 blockers). Agents with alpha 1a specificity, such as tamsulosin, act primarily on the prostate but are not devoid of hypotensive effects. It is estimated that asymptomatic hypotension occurs in 7% with tamsulosin therapy 3, 24, and in an animal study, it has been shown that tamsulosin caused a greater reduction of BP in older dogs, while silodosin had a less hypotensive effect in all age groups 25. The dose-limiting adverse reaction was postural hypotension. Applies to: Renal DysfunctionThe use of silodosin is contraindicated in patients with severe renal impairment (CrCl < 30 mL/min). There does not appear to be a benefit in stopping antiadrenergic agents therapy prior to the cataracts surgery.Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Therapy should be initiated with the lowest dosage possible and titrated gradually based on patient response and tolerance in accordance with the individual product package labeling. Available for Android and iOS devices. Hypotension has been observed when intravenous injection is too rapid. Caution and regular monitoring is recommended in patients with moderate renal impairment as the plasma concentrations can increase three times higher when compared with subjects with normal renal function. No dosage adjustment is needed in patients with mild or moderate hepatic impairment.Major Potential Hazard, Moderate plausibility. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.Things to remember when you fill your prescription.WebMD does not provide medical advice, diagnosis or treatment. Major Potential Hazard, Moderate plausibility. Side effects include retrograde ejaculation, orthostatic hypotension, dizziness, diarrhea, thirst, nasal stuffiness and headache. To avoid this response, the solution should not be injected more rapidly than 1 mL per minute. If a patient is undergoing cataract surgery, the ophthalmologist should be prepared for possible modifications of the surgical technique (iris hooks, iris dilator rings). Postmarketing reports: Circulatory collapse, congenital heart disease (including ventricular septal defect and patent ductus arteriosis), hypertension, hypotension, tachycardia . During initiation or reinstitution of therapy and following an increase in dosage, patients should be advised not to rise abruptly from a sitting or recumbent position and to avoid situations where injury could result if syncope occur. Caution is also advised in patients who are dehydrated (e.g., due to severe or prolonged diarrhea or vomiting), since they may be more sensitive to the hypotensive effect of the drugs. Silodosin, an α1-adrenoceptor ... One is a combination protocol, involving injections of Depo-Provera to prevent spermatogenesis, combined with the topical application of testosterone gel to provide hormonal support. 8,11 . Select one or more newsletters to continue. … Without treatment it can lead to serious and even life-threatening health problems. Applies to: Hypotension, Syncope, DehydrationPeripheral alpha 1- adrenergic receptor blocking agents (aka alpha 1- blockers) cause vasodilation and can produce marked hypotension, especially orthostatic hypotension with syncope or other postural symptoms such as dizziness, lightheadedness, and palpitations. Low blood pressure is a difficult clinical finding for a healthcare professional to address. The recommended dose is 4 to 8 mg once daily.