Obstructive lung disease is a common problem, and the incidence of asthma among children in westernized countries has been estimated to be 6–12% (1)(2). Theophylline is a methylxanthine compound that is used for the treatment of asthma, chronic obstructive pulmonary disease (COPD; chronic bronchitis and emphysema), and premature apnea.The bronchodilatory effects of theophylline are useful primarily for patients with asthma because bronchospasm is a key component of that disease state. If we started with the straight line When we are faced with a relationship between factors in a physiologic process shown on a plot of data representing this process, we can imagine the relationship as a geometric curve typifying the essence of the dependence of one factor upon the other. Pharmacy Times web site.

Desirable standards of performance for drug monitoring. • Risk of may be increased in those with renal insufficiency, dialysis, low baseline Hgb levels, Refer to the quality assurance issues elsewhere (Theophylline is a metabolite of caffeine. Get Free Access Through Your Institution

and maintain therapeutic serum levels and avoid toxicity. Warner A, Privatera A, Bates D. Antiepileptic drugs: standards of laboratory practice. Shauss ARE, Wertheim DL, Bonagura VR, Valacer DJ. minimize the risk of toxicity, doses of theophylline should be Below 10 mg lIncreased clearance is seen in children (1–16 years old) and in cigarette and marijuana smokers.

Cautionary note on contamination of reagents used for molecular detection of SARS-CoV-2 1984 Oct; 101 (4):457–462. This is most efficiently done by a series of pharmacokinetic calculations using Bayesian or other estimates (Plasma and serum are appropriate samples. ScienceDirect ® is a registered trademark of Elsevier B.V.URL: https://www.sciencedirect.com/science/article/pii/B9780123848642000135URL: https://www.sciencedirect.com/science/article/pii/B9780122147302500157URL: https://www.sciencedirect.com/science/article/pii/B978012384864200007XURL: https://www.sciencedirect.com/science/article/pii/B9780123848642000196URL: https://www.sciencedirect.com/science/article/pii/B9780323481106000302URL: https://www.sciencedirect.com/science/article/pii/B9780444537171015298URL: https://www.sciencedirect.com/science/article/pii/B9780123848642000214URL: https://www.sciencedirect.com/science/article/pii/B978044453717100891XURL: https://www.sciencedirect.com/science/article/pii/B0123708796004890Data for a male patient (patient 15) in DB3 was deleted because the patient’s age was unknown.THEODORE K. CHRISTOPOULOS, ELEFTHERIOS P. DIAMANDIS, in Pharmacology and Physiology for Anesthesia (Second Edition)Pyrantel Parasiticide Therapy in Humans and Domestic AnimalsScienceDirect ® is a registered trademark of Elsevier B.V. Disclaimer: These citations have been automatically generated based on the information we have and it may not be 100% accurate.

Monitoring Parameters Heart rate, blood pressure (base need for dosage increase on trough blood pressure measurements and for tolerance on standing systolic pressure 1 hour after dosing); renal studies, BUN, liver function; blood glucose in diabetics; in patients with increased risk for developing renal dysfunction, monitor during dosage titration. with a minimum of side effects. doses may result in dramatic increases in serum concentrations. Before calculating an initial dose or adjusting the maintenance tailor each drug model to fit your patient population, or you can create Effect of inhaled fermoterol and budesonide on exacerbations of asthma. There is no significant circadian variation in theophylline metabolism, although there may be delayed absorption at night, which may relate to the supine posture.We use cookies to help provide and enhance our service and tailor content and ads.
are essential for accurate dosage adjustment. Non-steady-state concentrations may be indicated in selected situations. The precision of the enzyme-multiplied immunoassay technique appears acceptable in view of the wide therapeutic index and low toxicity of caffeine. Theophylline is structurally classified as a methylxanthine.

congestive heart failure, other diseases and drug interactions all

greater than 20 mg/l. Severe life-threatening toxicity has been reported at concentrations of 346 mg/L (346 μg/mL) (Because the use of caffeine is limited to the neonate, it is unlikely that the need for caffeine monitoring will extend beyond the current practice of supporting neonatal intensive care units.Holgate ST.