UNIPRIM POWDER FOR HORSES contains 67 mg trimethoprim and 333 mg sulfadiazine per gram.UNIPRIM POWDER FOR HORSES is a combination of trimethoprim and sulfadiazine in the ratio of 1 part to 5 parts by weight, which provides effective antibacterial activity against a wide range of bacterial infections in animals.Trimethoprim is 2, 4 diamino-5-(3,4,5-trimethoxybenzyl) pyrimidine.Sulfadiazine, in common with other sulfonamides, inhibits bacterial synthesis of dihydrofolic acid by competing with Trimethoprim and sulfadiazine thus imposes a sequential double blockade on bacterial metabolism. Neither trimethoprim nor sulfadiazine interferes with the excretion pattern of the other.UNIPRIM POWDER FOR HORSES is indicated in horses where potent systemic antibacterial action against sensitive organisms is required. If significant reduction in the count of any formed blood element is noted, treatment with UNIPRIM POWDER FOR HORSES should be discontinued.UNIPRIM POWDER FOR HORSES is available in 37.5 g packets, 1125 g packets, 200 g jars, 400 g jars, 1200 g jars, 2000 g pails, and 12 kg boxes. Uniprim is an FDA-approved trimethoprim and sulfadiazine oral antibiotic powder for horses. UNIPRIM POWDER FOR HORSES is indicated where control of bacterial infections is required during treatment of:UNIPRIM POWDER FOR HORSES is well tolerated by foals.Trimethoprim and sulfadiazine should not be used in horses showing marked liver parenchymal damage, blood dyscrasias, or in those with history of sulfonamide sensitivity.Do not use in horses intended for human consumption.During clinical trials, one case of anorexia and one case of loose feces following treatment with the drug were reported.Individual animal hypersensitivity may result in local or generalized reactions, sometimes fatal.
Anaphylactoid reactions, although rare, may also occur.To report suspected adverse drug events, for technical assistance or to obtain a copy of the Safety Data Sheet (SDS), contact Neogen Corporation at 859-254-1221 or animalsafety.neogen.com.For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS or online at www.fda.gov/reportanimalae.Water should be readily available to horses receiving sulfonamide therapy. Apple Flavored UNIPRIM POWDER FOR HORSES is available in 37.5 g packets, 1125 g packets, 200 g jars, 400 g jars, 1200 g jars, and 2000 g pails.Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian.AVERAGE MINIMUM INHIBITORY CONCENTRATION (MIC-mcg/mL)AVERAGE MINIMUM INHIBITORY CONCENTRATION OF SULFADIAZINE-RESISTANT STRAINS (MIC-mcg/mL)The usual course of treatment is a single, daily dose for 5 to 7 days. The effect, which may have been related to a resolving infection, was not seen in a second similar trial.Slight to moderate reductions in hematopoietic activity following high, prolonged dosage in several species have been recorded.

Available for Android and iOS devices. UNIPRIM was designed specifically for horses and is cost-effective when compared to other competitors. During long-term treatment of horses, periodic platelet counts and white and red blood cell counts are advisable.The usual course of treatment is a single, daily dose for 5 to 7 days.Continue acute infection therapy for 2 or 3 days after clinical signs have subsided.If no improvement of acute infections is seen in 3 to 5 days, reevaluate the diagnosis.UNIPRIM Powder may be used alone or in conjunction with intravenous dosing. The mean serum elimination half-life for sulfadiazine is about 4 to 5.5 hours.Usually, the concentration of an antibacterial in the blood and the The following table shows the average concentration of trimethoprim and sulfadiazine, as measured in either serum or plasma, in twenty-four adult horses observed after a single dose of UNIPRIM Powder:Excretion of trimethoprim/sulfadiazine is chiefly by the kidneys, by both glomerular filtration and tubular secretion.

This antibiotic treatment combines sulfadiazine and trimethoprim, which work together to provide increased … Studies to date show there is no detrimental effect on stallion spermatogenesis with or following the recommended dose of trimethoprim and sulfadiazine.The recommended dosage is 3.75 g UNIPRIM POWDER FOR HORSES per 110 lbs (50 kg) body weight per day. Sulfadiazine absorption is slower, requiring 2.5 to 6 hours to reach peak concentrations. Uniprim Powder Dosage And Administration The recommended dosage is 3.75 g UNIPRIM Powder per 110 lbs (50 kg) body weight per day.

The mean serum elimination half-life is 2 to 2.5 hours. Sulfadiazine absorption is slower, requiring 2.5 to 6 hours to reach peak concentrations. The reasons are: animals do not synthesize folic acid and cannot, therefore, be directly affected by sulfadiazine; and although animals must reduce their dietary folic acid to tetrahydrofolic acid, trimethoprim does not affect this reduction because its affinity for dihydrofolate reductase of mammals is significantly less than for the corresponding bacterial enzyme.Trimethoprim/sulfadiazine is active against a wide spectrum of bacterial pathogens, both gram-negative and gram-positive.
Administer UNIPRIM POWDER FOR HORSES orally once a day in a small amount of palatable feed.