Subsequently, the physician may continue decreasing the dose, but at a more gradual rate [see Seizures have occurred with venlafaxine therapy. There was no evidence for any greater effectiveness of the 150 to 225 mg per day group compared to the 75 mg per day group in the 6-month study.Examination of subsets of the population studied did not reveal any differential responsiveness on the basis of gender. Effexor XR is an extended-release capsule for once-a-day oral administration that contains venlafaxine hydrochloride, a serotonin and norepinephrine reuptake inhibitor (SNRI). This means you may need to take it with other medications to treat your condition.Venlafaxine belongs to a class of antidepressant drugs called SNRIs work by increasing the levels of substances called serotonin and norepinephrine in your brain.
SSRIs and SNRIs, including Effexor XR, have been associated with cases of clinically significant hyponatremia in elderly patients, who may be at greater risk for this adverse event [see The pharmacokinetics of venlafaxine and ODV are not substantially altered in the elderly [see A population pharmacokinetic analysis of 404 Effexor-treated patients from two studies involving both twice daily and three times daily regimens showed that dose-normalized trough plasma levels of either venlafaxine or ODV were unaltered by age or gender differences. Call your doctor right away if you become pregnant while taking this drug.All possible dosages and drug forms may not be included here. Venlor XR (Generic Venlafaxine Hydrochloride Capsules) is used in the treatment of major depressive disorder, Generalized Anxiety Disorder (GAD), Social Anxiety Disorder, also known as Social Phobia as well as for the treatment of panic disorder. Effexor XR, like many antidepressants, should be used cautiously in patients with a history of seizures and should be discontinued in any patient who develops seizures. Patients should be given the opportunity to discuss the contents of the Medication Guide and to obtain answers to any questions they may have. The complete text of the Medication Guide is reprinted at the end of this document.
than placebo) in Effexor XR treated patients in short-term, placebo-controlled, fixed-and flexible-dose clinical studies (doses 37.5 to 225 mg per day) are shown in Table 9.The adverse reaction profile did not differ substantially between the different patient populations.In placebo-controlled premarketing studies, there were increases in mean blood pressure (see Table 10). Venlafaxine is a member of the serotonin-norepinephrine reuptake inhibitors drug class and is commonly used for Anxiety, Anxiety and Stress, Autism, and others. Healthcare professionals should instruct patients not to take Effexor XR with an MAOI or within 14 days of stopping an MAOI and to allow 7 days after stopping Effexor XR before starting an MAOI [see Patients should be cautioned about the risk of serotonin syndrome, with the concomitant use of Effexor XR and triptans, tramadol, amphetamines, tryptophan supplements, with antipsychotics or other Advise patients that they should have regular monitoring of blood pressure when taking Effexor XR [see Patients should be cautioned about the concomitant use of Effexor XR and NSAIDs, aspirin, warfarin, or other drugs that affect coagulation since combined use of psychotropic drugs that interfere with serotonin reuptake and these agents has been associated with an increased risk of bleeding [see Patients should be advised that taking Effexor XR can cause mild pupillary dilation, which in susceptible individuals, can lead to an episode of angle closure Advise patients, their families and caregivers to observe for signs of activation of mania/hypomania [see Caution is advised in administering Effexor XR to patients with cardiovascular, cerebrovascular, or Advise patients not to stop taking Effexor XR without talking first with their healthcare professional. A dose-response relationship for effectiveness in GAD was not clearly established in the 75 to 225 mg per day dose range studied.Two 6-month studies, one evaluating Effexor XR doses of 37.5, 75, and 150 mg per day (study 3) and the other evaluating Effexor XR doses of 75 to 225 mg per day (study 4), showed that daily doses of 75 mg or higher were more effective than placebo on the HAM-A total, both the HAM-A anxiety and tension items, and the CGI scale during 6 months of treatment.
SSRIs and SNRIs, including Effexor XR, have been associated with cases of clinically significant hyponatremia in elderly patients, who may be at greater risk for this adverse event [see The pharmacokinetics of venlafaxine and ODV are not substantially altered in the elderly [see A population pharmacokinetic analysis of 404 Effexor-treated patients from two studies involving both twice daily and three times daily regimens showed that dose-normalized trough plasma levels of either venlafaxine or ODV were unaltered by age or gender differences. Call your doctor right away if you become pregnant while taking this drug.All possible dosages and drug forms may not be included here. Venlor XR (Generic Venlafaxine Hydrochloride Capsules) is used in the treatment of major depressive disorder, Generalized Anxiety Disorder (GAD), Social Anxiety Disorder, also known as Social Phobia as well as for the treatment of panic disorder. Effexor XR, like many antidepressants, should be used cautiously in patients with a history of seizures and should be discontinued in any patient who develops seizures. Patients should be given the opportunity to discuss the contents of the Medication Guide and to obtain answers to any questions they may have. The complete text of the Medication Guide is reprinted at the end of this document.
than placebo) in Effexor XR treated patients in short-term, placebo-controlled, fixed-and flexible-dose clinical studies (doses 37.5 to 225 mg per day) are shown in Table 9.The adverse reaction profile did not differ substantially between the different patient populations.In placebo-controlled premarketing studies, there were increases in mean blood pressure (see Table 10). Venlafaxine is a member of the serotonin-norepinephrine reuptake inhibitors drug class and is commonly used for Anxiety, Anxiety and Stress, Autism, and others. Healthcare professionals should instruct patients not to take Effexor XR with an MAOI or within 14 days of stopping an MAOI and to allow 7 days after stopping Effexor XR before starting an MAOI [see Patients should be cautioned about the risk of serotonin syndrome, with the concomitant use of Effexor XR and triptans, tramadol, amphetamines, tryptophan supplements, with antipsychotics or other Advise patients that they should have regular monitoring of blood pressure when taking Effexor XR [see Patients should be cautioned about the concomitant use of Effexor XR and NSAIDs, aspirin, warfarin, or other drugs that affect coagulation since combined use of psychotropic drugs that interfere with serotonin reuptake and these agents has been associated with an increased risk of bleeding [see Patients should be advised that taking Effexor XR can cause mild pupillary dilation, which in susceptible individuals, can lead to an episode of angle closure Advise patients, their families and caregivers to observe for signs of activation of mania/hypomania [see Caution is advised in administering Effexor XR to patients with cardiovascular, cerebrovascular, or Advise patients not to stop taking Effexor XR without talking first with their healthcare professional. A dose-response relationship for effectiveness in GAD was not clearly established in the 75 to 225 mg per day dose range studied.Two 6-month studies, one evaluating Effexor XR doses of 37.5, 75, and 150 mg per day (study 3) and the other evaluating Effexor XR doses of 75 to 225 mg per day (study 4), showed that daily doses of 75 mg or higher were more effective than placebo on the HAM-A total, both the HAM-A anxiety and tension items, and the CGI scale during 6 months of treatment.