Rachlis A(1), Fanning MM.


These oral embryo-fetal development studies in the rat and rabbit revealed no evidence of fetal malformations with zidovudine. Discoloration has occurred as longitudinal streaks or transverse bands.A case of macular edema in a patient with a history of anterior Local reaction, pain, and slight irritation were reported infrequently during IV administration.1. Barnett JH, Gilson I "Zidovudine-related thrombocytopenia simulating rapid growth of Kaposi's sarcoma."

Serial echocardiograms were obtained for 382 infants without HIV infection (36 with zidovudine exposure) and 58 HIV-infected infants (12 with zidovudine exposure).

Am J Hematol 30 (1989): 263-424. Try This Simple 7 Second Daily Ritual For Yourself Here ➢➢➢ https://bit.ly/2PJu978

Arch Intern Med 152 (1992): 850-16.



Although not all of these side effects may occur, if they do occur they may need medical attention.Some side effects of zidovudine may occur that usually Check with your health care professional if any of the following side effects The most common side effects reported during adult clinical trials were headache, malaise, nausea, anorexia, and vomiting; side effects reported most often with IV administration were anemia and neutropenia. Forty of the 58 HIV-infected infants received one or more therapies for HIV infection other than zidovudine during the first 14 months of follow-up (The median length of in utero exposure to zidovudine was 103 days (data on length of exposure were available for 85 of 107 fetuses with any exposure [79 percent]). Female sex and obesity may be risk factors Immune reconstitution syndrome has been reported in patients treated with combination antiretroviral therapy, including Zidovudine. Ann Intern Med 112 (1990): 727-3720. Lancet 357 (2001): 592-837.


In some subjects harboring Zidovudine-resistant virus at baseline, phenotypic sensitivity to Zidovudine was restored by 12 weeks of treatment with lamivudine and Zidovudine.Cross-resistance has been observed among NRTIs. AIDS 3 (1989): 555-6113.

Glaxo Wellcome, Research Triangle Park, NC. Retrovir (zidovudine)."

Studies of ventricular dysfunction conducted by members of our groupThe progressively more severe manifestations of drug-induced mitochondrial damage in cardiomyocytes are cardiomyopathy, congestive heart failure, and death due to pump failure, or sudden cardiac death. Warnke D, Barreto J, Temesgen Z "Antiretroviral drugs."

AZT belongs to a group of drugs known as nucleoside reverse transcriptase inhibitors (NRTIs). Sep 1, 2020

After 10 months of age, no infants had depressed fractional shortening, regardless of zidovudine exposure or HIV status.In our study, infants born to HIV-infected women and exposed to zidovudine were no more likely to have abnormal left ventricular structure and function than were infants who did not have zidovudine treatment throughout the first 14 months of life.

The chemical name of Zidovudine is 3'-azido-3'-deoxythymidine; it has the following structural formula:Zidovudine USP is a white to beige, odorless, crystalline solid with a molecular weight of 267.24 and a solubility of 20.1 mg per mL in water at 25°C. N Engl J Med 322 (1990): 1098-10547. Finally, the effects of dosage were not assessed in this study.We found no evidence of acute or chronic adverse cardiac effects in non–HIV-infected infants exposed to zidovudine in the perinatal period.

The infants who were found after birth not to have HIV infection had a median length of in utero exposure to zidovudine of 105 days; those who were found after birth to be infected with HIV were exposed to zidovudine in utero for a median of 68 days.

Commonly reported side effects of zidovudine include:headache, nausea, neutropenia, vomiting, anemia, anorexia, and malaise. The original study protocol was not designed to gather complete data about antiretroviral therapy.

Zidovudine toxicity.

In studies in monkeys, zidovudine at 21 percent and 86 percent of the human daily dose was administered to females in the second half of pregnancy, and the effects on fetal cardiomyocytes were observed. Pharmacotherapy 26 (2006): 1111-3311.



Severity of interaction: Severe Evidence for interaction: Anecdotal.