Because of the potential for serious gastrointestinal adverse reactions in the breast-fed infant, an alternative drug to clindamycin … © 1998-2020 Mayo Foundation for Medical Education and Research (MFMER). They are dosed the same as chewable tablets. If you need help in planning the best times to take your medicine, check with your doctor. To help keep the amount constant, do not miss any doses. Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration whenever solution and container permit. the Diarrhea is a common problem caused by antibiotics which usually ends when the antibiotic is discontinued. The drugs are mostly for emergency, gastrointestinal, upper respiratory tract infection and antibiotics. In life-threatening situations due to either aerobes or anaerobes these doses may be increased. Missed Dose In the presence of strong CYP3A4 inhibitors, monitor for adverse reactions. Its use should be reserved for Bacteriologic studies should be performed to determine the causative organisms and their susceptibility to clindamycin.Indicated surgical procedures should be performed in conjunction with antibiotic therapy.CLEOCIN PHOSPHATE is indicated in the treatment of serious infections caused by susceptible strains of the designated organisms in the conditions listed below:Bone and joint infections including acute hematogenous To reduce the development of drug-resistant bacteria and maintain the effectiveness of CLEOCIN PHOSPHATE and other If diarrhea occurs during therapy, this antibiotic should be discontinued (see More severe infections, particularly those due to proven or suspected For more serious infections, these doses may have to be increased. Pediatric dosage calculator: Quickly find the dosage of commonly used IV and Oral drug for children! However, other reported clinical experience indicates that antibiotic-associated colitis and diarrhea (due to Pharmacokinetic studies with clindamycin have shown no clinically important differences between young and elderly subjects with normal hepatic function and normal (age-adjusted) renal function after oral or intravenous administration.Significant mortality was observed in mice at an intravenous dose of 855 mg/kg and in rats at an oral or subcutaneous dose of approximately 2618 mg/kg.
Clindamycin is excreted into human breast milk after administration by the oral or parenteral routes in concentrations of less than 0.5 to 3.8 mcg/mL. Therefore inhibitors of CYP3A4 and CYP3A5 may increase plasma concentrations of clindamycin and inducers of these isoenzymes may reduce plasma concentrations of clindamycin. The lower dosage may be adequate for small prematures.Parenteral (IM or IV) Administration: 20 to 40 mg/kg/day in 3 or 4 equal doses. Peds Dosing . Children's Benadryl Fastmelts. Always check the concentration is the same before using this dose table. Usual oral dosage: children4: 4-10 mg/kg/dose every 6-8 hours children > 12 years4: 200 mg every 4-6 hours as needed (maximum 1200 mg/24 hrs) adults2: 400 mg/dose every 4-6 hours * Pediatric dosage should not exceed adult dosage. An equilibrium state is reached by the third dose. To do so may increase the chance of side effects. Clindamycin also comes as an oral solution, … Measure the oral liquid correctly using the marked measuring spoon that comes with the package. The dose is usually 37.5 milligrams (mg) or 1/2 teaspoonful 3 times a day. In the presence of strong CYP3A4 inducers such as rifampicin, monitor for loss of effectiveness.Antagonism has been demonstrated between clindamycin and If CDAD is suspected or confirmed, ongoing antibiotic use not directed against Severe hypersensitivity reactions, including severe skin reactions such as toxic epidermal necrolysis (TEN), drug reaction with In case of such an anaphylactic or severe hypersensitivity reaction, discontinue treatment permanently and institute appropriate therapy.A careful inquiry should be made concerning previous sensitivities to drugs and other allergens.This product contains benzyl alcohol as a preservative. The opacity will diminish gradually.You are encouraged to report negative side effects of prescription drugs to the FDA. Revised: 2017The following reactions have been reported with the use of Clindamycin is metabolized predominantly by CYP3A4, and to a lesser extent by CYP3A5, to the major metabolite clindamycin sulfoxide and minor metabolite N-desmethylclindamycin. As an alternative to dosing on a body weight basis, pediatric patients may be dosed on the basis of square meters body surface: 350 mg/mParenteral therapy may be changed to oral CLEOCIN PEDIATRICRAdministration of more than 1200 mg in a single 1-hour infusion is not recommended.Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.Physical and biological compatibility studies monitored for 24 hours at room temperature have demonstrated no inactivation or incompatibility with the use of CLEOCIN PHOSPHATE Sterile Solution (clindamycin phosphate) in IV solutions containing sodium chloride, glucose, calcium or The following drugs are physically incompatible with clindamycin phosphate: ampicillin sodium, phenytoin sodium, The compatibility and duration of stability of drug admixtures will vary depending on concentration and other conditions. If you have a "strep'' infection, you should keep using this medicine for at least 10 days. Avoid temperatures above 30°C.Distributed by: Pfizer, Pharmacia&Upjohn Co, Division Of Pfizer Inc, New York, NY 10017. practice suggests that compounded admixtures should be administered as soon after preparation as is feasible.6, 9 and 12 mg/mL (equivalent to clindamycin base) in dextrose injection 5%, sodium chloride injection 0.9%, or Lactated Ringers Injection in minibags demonstrated physical and chemical stability for at least eight weeks at -10°C.Frozen solutions should be thawed at room temperature and not refrozen.The Pharmacy Bulk Package is for use in a Pharmacy Admixture Service only under a laminar flow hood. Take the capsule with a full glass (8 ounces) of water.


Each mL contains the equivalent of 150 mg clindamycin, 0.5 mg disodium edetate and 9.45 mg benzyl alcohol added as preservative in each mL.