Zhang L, Yu H, Sun Y, et al.

Changes in thyroid status of the patient may necessitate adjustment in dosage.Patients who are on corticosteroids are more susceptible to infections than healthy individuals. It is designated chemically as 9-fluoro-11β,17,21trihydroxy-16α-methylpregna-1,4-diene-3,20-dione. Thus, results of the DST should be interpreted with caution in these patients.Patients on digitalis glycosides may be at increased risk of arrhythmias due to hypokalemia.Ephedrine may enhance the metabolic clearance of corticosteroids, resulting in decreased blood levels and lessened Drugs which induce cytochrome P450 3A4 (CYP 3A4) enzyme activity (Ketoconazole has been reported to decrease the metabolism of certain corticosteroids by up to 60%, leading to increased risk of corticosteroid side effects. Clinical improvement or recovery after stopping corticosteroids may require weeks to years.Psychic derangements may appear when corticosteroids are used, ranging from euphoria, insomnia, mood swings, personality changes, and severe depression, to frank psychotic manifestations. Routine administration of vaccines or toxoids should be deferred until corticosteroid therapy is discontinued if possible (see No adequate studies have been conducted in animals to determine whether corticosteroids have a potential for carcinogenesis or mutagenesis.Steroids may increase or decrease motility and number of spermatozoa in some patients.Corticosteroids have been shown to be teratogenic in many species when given in doses equivalent to the human dose. The contribution of the underlying disease and/or prior corticosteroid treatment to the risk is also not known. Infection with any pathogen (viral, bacterial, fungal, protozoan or helminthic) in any location of the body may be associated with the use of corticosteroids alone or in combination with other immunosuppressive agents.These infections may be mild to severe. Available for Android and iOS devices.

Drugs R D 2012;12(2):101-6. With increasing doses of corticosteroids, the rate of occurrence of infectious complications increases.

In addition, the 0.5 mg tablet contains D&C Yellow #10 and FD&C Yellow #5. This, together with a decrease in the protein matrix of the bone secondary to an increase in protein catabolism, and reduced sex hormone production, may lead to inhibition of bone growth in pediatric patients and the development of osteoporosis at any age. Since mineralocorticoid secretion may be impaired, salt and/or a mineralocorticoid should be administered concurrently.Steroids should be used with caution in active or latent peptic ulcers, Corticosteroids decrease bone formation and increase bone Although controlled clinical trials have shown corticosteroids to be effective in speeding the Psychic derangements may appear when corticosteroids are used, ranging from No adequate studies have been conducted in animals to determine whether corticosteroids have a potential for carcinogenesis or Steroids may increase or decrease motility and number of spermatozoa in some patients.Systemically administered corticosteroids appear in human milk and could suppress growth, interfere with The efficacy and safety of corticosteroids in the pediatric population are based on the well-established course of effect of corticosteroids, which is similar in pediatric and adult populations. It is stable in air. It is designated chemically as 9-fluoro-11β, 17, 21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione.The structural for… It is practically insoluble in water. When these substances or their derivatives are injected intramuscularly or into joint spaces, their relative properties may be greatly altered.In acute, self-limited allergic disorders or acute exacerbations of chronic allergic disorders,Dexamethasone Sodium Phosphate injection, 4 mg per mL:We comply with the HONcode standard for trustworthy health information - As prolonged use may cause adrenal insufficiency and make patients dependent on corticosteroids, they should advise any medical attendants that they are taking corticosteroids and they should seek medical advice at once should they develop an Persons who are on corticosteroids should be warned to avoid exposure to You are encouraged to report negative side effects of prescription drugs to the FDA.

Adrenocortical insufficiency may result from too rapid withdrawal of corticosteroids and may be minimized by gradual reduction of dosage. Tablets DECADRON 0.5 mg also contain D&C Yellow 10 and FD&C Yellow 6. It is stable in air. Other indications for pediatric use of corticosteroids, e.g., severe The adverse effects of corticosteroids in pediatric patients are similar to those in adults (see Clinical studies did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects.

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If after long-term therapy the drug is to be stopped, it is recommended that it be withdrawn gradually rather than abruptly.In the treatment of acute exacerbations of multiple sclerosis, daily doses of 30 mg of dexamethasone for a week followed by 4 to 12 mg every other day for one month have been shown to be effective (see In pediatric patients, the initial dose of dexamethasone may vary depending on the specific disease entity being treated. Following prolonged therapy, withdrawal of corticosteroids may result in symptoms of the corticosteroid withdrawal syndrome including, myalgia, arthralgia, and malaise.Persons who are on corticosteroids should be warned to avoid exposure to chickenpox or measles.Patients should also be advised that if they are exposed, medical advice should be sought without delay.Aminoglutethimide may diminish adrenal suppression by corticosteroids.When corticosteroids are administered concomitantly with potassium-depleting agents (e.g., amphotericin B, diuretics), patients should be observed closely for development of hypokalemia. If exposed to chickenpox, prophylaxis with varicella zoster immune globulin (VZIG) may be indicated.