The patient continued receiving lamotrigine (50 mg/day) with flunitrazepam (2 mg) with symptomatic remission.Authors of the case report postulate that lamotrigine may facilitate anxiolytic effects through the modulation of GABA (gamma-aminobutyric-acid). We all experience feelings of sadness from time to time. Moreover, the increases in antioxidant valuates from lamotrigine exceeded those derived from other medications such as aripiprazole and escitalopram.The results from this animal study suggests that lamotrigine may have significant, overlooked antioxidant effects. medications, supplements, etc. Research by Hassel, Taubøll, and Gjerstad (2001) revealed that chronic administration of lamotrigine to rats (10 mg/kg/day for 90 days) increased concentrations of hippocampal GABA by 25% and enhanced GABA turnover.Other work by Wang, Sun, Chen, and Young (2002) discovered that lamotrigine enhanced expression of GABA-A receptor beta-3 subunits in hippocampal neurons of rats, supporting the hypothesis that lamotrigine exerts a GABAergic effect. Do you have another neuropsychiatric condition for which your doctor originally recommended lamotrigine, or did your doctor prescribe it off-label specifically for anxiety?How many medications did your doctor require you to try before deciding to test lamotrigine? It was concluded that lamotrigine augmentation to a preexisting SSRI may prove efficacious for the treatment of refractory OCD, a specific anxiety disorder characterized by a disruptive, uncontrollable combination of obsessions and compulsions.Kishimoto, Goto, and Hashimoto (2014) documented a case report in which a 15-year-old Japanese female was diagnosed with mixed anxiety and depression, psychosomatic disorder, and PTSD – in accordance with ICD-10 criteria. Lamictal helps so much with my anxiety depression and racy thoughts. Share on Facebook. meta-analysis/review, RCT, case report, etc. Like everything else it takes time. Researchers theorized that the substantial increase in cerebral glucose metabolism was the primary reason for the amelioration of the woman’s symptoms.Additionally, it was suggested that the multi-drug combination modulates neural activity within the cortico-subcortical network and might favorably bolster connectivity between the hippocampus and cingulate. Researchers documented the most frequently diagnosed psychiatric comorbidities among patients with epilepsy respectively including:  anxiety, depression, panic, behavioral dysfunction, and psychosis.For this reason, researchers mention the potential advantages of taking a single antiepileptic agent capable of treating epilepsy and psychiatric comorbidities simultaneously. It’s reasonable to suspect that the effect of lamotrigine upon these additional targets could modestly contribute to its total anxiolytic effect.Though evidence suggests that lamotrigine modulates potassium channels, it remains unclear as to whether the specific channels modulated and/or the degree of modulation in human lamotrigine users would contribute to an anxiolytic effect. That said, it is unclear as to whether lamotrigine exerts as potent of an antioxidant effect in the brains of human users. Results indicated that administration of lamotrigine significantly increased antioxidant status, thereby counteracting oxidative stress. Additionally, preliminary testing of potassium channel modulators reveals that they could prove useful as anxiolytics. My detailed story soon to follow.This is encouraging. Missing doses of lamotrigine may increase your risk for a relapse in your mood symptoms.Do not stop taking lamotrigine or change your dose without talking to your healthcare provider first.In order for lamotrigine to work properly, it should be taken every day as ordered by your healthcare provider.If you are planning on becoming pregnant, notify your healthcare provider so that he/she can best manage your medications. For the review, researchers compiled all studies published between 1990 and 2012 in which lamotrigine was administered to treat psychiatric conditions for which it does not have FDA approval. Initially she was treated with the drug flunitrazepam (2 mg) and an analgesic while at the clinic, but returned to school. Among the most significant of potential drawbacks associated with utilizing lamotrigine to treat anxiety is that it may exacerbate a person’s preexisting symptoms of anxiety.