Jak każdy lek, również Propranolol WZF może powodować działania niepożądane, chociaż nie wystąpią one u wszystkich chorych stosujących ten preparat. These findings are inconsistent with another study, in which administration of testosterone cypionate confirmed the stimulatory role of this hormone on propranolol metabolism and concluded that the clearance of propranolol in men is dependent on circulating concentrations of testosterone.

See USP Controlled Room Temperature. Peak plasma concentrations occur about 1 to 4 hours after an oral dose.Administration of protein-rich foods increase the bioavailability of propranolol by about 50% with no change in time to peak concentration, plasma binding, half-life, or the amount of unchanged drug in the urine.Approximately 90% of circulating propranolol is bound to plasma proteins (albumin and alphaPropranolol crosses the blood-brain barrier and the placenta, and is distributed into breast milk.Propranolol is extensively metabolized with most metabolites appearing in the urine. Familial or essential tremor consists of involuntary, rhythmic, oscillatory movements, usually limited to the upper limbs. Unable to load your collection due to an error

Verapamil does not affect the pharmacokinetics of propranolol.Administration of zolmitriptan or rizatriptan with propranolol resulted in increased concentrations of zolmitriptan (AUC increased by 56% and CCoadministration of theophylline with propranolol decreases theophylline oral clearance by 30% to 52%.Propranolol can inhibit the metabolism of diazepam, resulting in increased concentrations of diazepam and its metabolites. If treatment is to be discontinued, reduce dosage gradually over a period of several weeks. Significant drug effects on both total and free testosterone were found during treatment with all four beta-blockers, although it appeared that the nonselective drugs (pindolol, propranolol) were associated with the greatest reduction in testosterone. 43353-084-60,

Interactions with Substrates, Inhibitors or Inducers of Cytochrome P-450 EnzymesThere have been reports of exacerbation of angina and, in some cases, myocardial infarction, following abrupt discontinuance of propranolol therapy.

Intrauterine growth retardation, small placentas, and congenital abnormalities have been reported in neonates whose mothers received propranolol during pregnancy. Farmakologiczne zablokowanie receptorów beta uniemożliwia ich pobudzenie, a przez to ogranicza skutki działania adrenaliny czy noradrenaliny na tkanki docelowe posiadające receptory beta. Działanie Propranololuopiera się blokowaniu receptorów, które występują na powierzchni komórek mięśniowych, gruczołowych czy nerwowych w wielu tkankach i narządach. In a study in which both male and female rats were exposed to propranolol hydrochloride in their diets at concentrations of up to 0.05% (about 50 mg/kg body weight and less than the MRHD), from 60 days prior to mating and throughout pregnancy and lactation for two generations, there were no effects on fertility. Hypoglycemia has been reported in patients taking propranolol after prolonged physical exertion and in patients with renal insufficiency.Beta-adrenergic blockade may mask certain clinical signs of hyperthyroidism. Although beta-blockers should be avoided in overt congestive heart failure, some have been shown to be highly beneficial when used with close follow-up in patients with a history of failure who are well compensated and are receiving additional therapies, including diuretics as needed. No correlation was found between age and the partial metabolic clearance to propranolol glucuronide (PPLG-conjugation).In a study of nine healthy women and 12 healthy men, neither the administration of testosterone nor the regular course of the menstrual cycle affected the plasma binding of the propranolol enantiomers.