Lowering blood pressure lowers the risk of fatal and non-fatal cardiovascular events, primarily strokes and myocardial infarctions. It was studied in patients already receiving ACE inhibitors, diuretics, and, in the majority of cases, digitalis. Common side effects of Toprol-XL include: hypotension. There were no notable differences in efficacy or the rate of adverse reactions between older and younger patients.In general, use a low initial starting dose in elderly patients given their greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.No studies have been performed with Toprol-XL in patients with hepatic impairment. However, if you add divorce and/or maybe job loss to that, it makes it even worse – I have met a lot of people in that situation. Individualize the dosage of Toprol-XL. The largest and most consistent cardiovascular outcome benefit has been a reduction in the risk of stroke, but reductions in myocardial infarction and cardiovascular mortality also have been seen regularly.Elevated systolic or diastolic pressure causes increased cardiovascular risk, and the absolute risk increase per mmHg is greater at higher blood pressures, so that even modest reductions of severe hypertension can provide substantial benefit. The systemic availability and half-life of metoprolol in patients with renal failure do not differ to a clinically significant degree from those in normal subjects. Concomitant use with beta blockers can increase the risk of bradycardia.If clonidine and a beta blocker, such as metoprolol are coadministered, withdraw the beta-blocker several days before the gradual withdrawal of clonidine because beta-blockers may exacerbate the rebound hypertension that can follow the withdrawal of clonidine. Select one or more newsletters to continue. Abrupt withdrawal of beta-blockade may precipitate a thyroid storm.While taking beta-blockers, patients with a history of severe anaphylactic reactions to a variety of allergens may be more reactive to repeated challenge and may be unresponsive to the usual doses of epinephrine used to treat an allergic reaction.Beta-blockers can precipitate or aggravate symptoms of arterial insufficiency in patients with peripheral vascular disease.Because of significant inotropic and chronotropic effects in patients treated with beta-blockers and calcium channel blockers of the verapamil and diltiazem type, caution should be exercised in patients treated with these agents concomitantly.The following adverse reactions are described elsewhere in labeling:Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice. Beta-blocker overdose may result in significant resistance to resuscitation with adrenergic agents, including beta-agonists. Side effects include low blood pressure, dreaming, diarrhea, abdominal cramps, and sore throat.

Toprol-XL is indicated for the treatment of hypertension, to lower blood pressure. Nonetheless, subgroup analyses can be difficult to interpret and it is not known whether these represent true differences or chance effects.All-cause mortality plus all-caused hospitalizationAll-cause mortality plus heart failure hospitalization1. Titration may be needed in some patients.Toprol-XL tablets are scored and can be divided; however, do not crush or chew the whole or half tablet.Toprol-XL is not recommended in pediatric patients < 6 years of age Individualize the dosage of Toprol-XL. Using an EAlthough beta-adrenergic receptor blockade is useful in the treatment of angina, hypertension, and heart failure there are situations in which sympathetic stimulation is vital. If angina markedly worsens or acute coronary ischemia develops, promptly reinstate Toprol-XL, and take measures appropriate for the management of unstable angina.