In the absence of metabolic activation, neither ALDACTONE nor potassium canrenoate has been shown to be mutagenic in mammalian tests In a three-litter reproduction study in which female rats received dietary doses of 15 and 50 mg ALDACTONE/kg/day, there were no effects on mating and fertility, but there was a small increase in incidence of stillborn pups at 50 mg/kg/day. to female mice during a two-week cohabitation period with untreated males, decreased the number of mated mice that conceived (effect shown to be caused by an inhibition of ovulation) and decreased the number of implanted embryos in those that became pregnant (effect shown to be caused by an inhibition of implantation), and at 200 mg/kg, also increased the latency period to mating.The Randomized Aldactone Evaluation Study (RALES) was a placebo controlled, double-blind study of the effect of spironolactone on mortality in patients with highly symptomatic heart failure and reduced ejection fraction.

In a 24-month study in which the same strain of rat was administered doses of about 10, 30, and 100 mg ALDACTONE/kg/day, the range of proliferative effects included significant increases in hepatocellular adenomas and testicular interstitial cell tumors in males, and significant increases in thyroid follicular cell adenomas and carcinomas in both sexes. Doses greater than 100 mg/day generally do not provide additional reductions in blood pressure ALDACTONE 25 mg tablets are round, light yellow, film-coated, with SEARLE and 1001 debossed on one side and ALDACTONE and 25 on the other side, supplied as:ALDACTONE 50 mg tablets are oval, light orange, scored, film-coated, with SEARLE and 1041 debossed on the scored side and ALDACTONE and 50 on the other side, supplied as:ALDACTONE 100 mg tablets are round, peach-colored, scored, film-coated, with SEARLE and 1031 debossed on the scored side and ALDACTONE and 100 on the other side, supplied as:Patients who receive ALDACTONE should be advised to avoid potassium supplements and foods containing high levels of potassium, including salt substitutes.This product's label may have been updated.

Spironolakton, obložena tableta, ATC C03DA01, SmPC (Povzetek glavnih značilnosti zdravila) Indikacije: Zdravilo Aldactone uporabljamo za zdravljenje: − primarnega hiperaldosteronizma (Connov sindrom) Zdravilo Aldactone je indicirano pri primarnem aldosteronizmu, kadar operativno zdravljenje ni primerno. It is unknown to what extent, if any, spironolactone may increase actual digoxin exposure. Patients who were intolerant of the initial dosage regimen had their dose decreased to one 25 mg tablet every other day at one to four weeks.

The median ejection fraction was 26%.

2016 Feb;83(1):52-68. doi: 10.1080/00243639.2016.1145894. Patients with a baseline serum creatinine of >2.5 mg/dL or a recent increase of 25% or with a baseline serum potassium of >5.0 mEq/L were excluded.Follow-up visits and laboratory measurements (including serum potassium and creatinine) were performed every four weeks for the first 12 weeks, then every 3 months for the first year, and then every 6 months thereafter.The initial dose of spironolactone was 25 mg once daily. If you are a consumer or patient please visit Spironolactone (Aldactone) is a diuretic. Dosage can be titrated at two-week intervals. Closely monitor pregnant patients for destabilization of their heart failure.Pregnant women with symptomatic cirrhosis generally have poor outcomes including hepatic failure, variceal hemorrhage, preterm delivery, fetal growth restriction and maternal death.

Grossman D, White K, Harris L, Reeves M, Blumenthal PD, Winikoff B, Grimes DA.Contraception. Copy the URL below and paste it into your RSS Reader application.DailyMed will deliver notification of updates and additions to Drug Label information currently shown on this site through its RSS feed.DailyMed will deliver this notification to your desktop, Web browser, or e-mail depending on the RSS Reader you select to use. It continuously releases hormones through the skin into the bloodstream to prevent pregnancy.

All pregnancies have a background risk of birth defect, loss or other adverse outcomes. Mifepristone, also known as RU-486, is a medication typically used in combination with misoprostol to bring about an abortion during pregnancy. By competing with aldosterone for receptor sites, spironolactone provides effective therapy for the edema and ascites in those conditions.

It is used to treat edema (fluid retention) that occurs with congestive heart failure, cirrhosis of the liver, and nephrotic syndrome. Many birth control pills, the patch, and the vaginal ring all contain a combination of estrogen and progestin.

These effects were associated with retarded ovarian follicle development and a reduction in circulating estrogen levels, which would be expected to impair mating, fertility, and fecundity.