0000013853 00000 n frequency which in turn may cause adverse effects.
According to different Pharmacopoeias, acyclovir is “slightly solubility in water” at 22-25 °C and solubility ranges from 1.2 to 1.6 mg/mL. endstream endobj 72 0 obj < Acyclovir is a nucleotide analog antiviral used to treat herpes simplex, Varicella zoster, herpes zoster, herpes labialis, and acute herpetic keratitis 10,11,12,13,14,15.Acyclovir is generally used first line in the treatment of these viruses and some products are indicated for patients as young as 6 years old. Similar dependences of aqueous solubility of both groups of the studied compounds were observed at higher temperatures 35 and 45 °C. 0000013922 00000 n 0000159102 00000 n dissolution also) and gastro intestinal permeability (which in turn is expected to improve the bioavailability) of acyclovir, Acyclovir, a popular antiviral drug, is associated with the problems of poor water solubility, low bioavailability (15-30%), low permeability (across the gastro intestinal membrane) and short half-life (3 hours) leading to high dosage frequency which in turn may cause adverse effects. 0000004831 00000 n 0000012014 00000 n
were prepared with β-CD (with or without the presence of hydrophilic excipients namely polyvinyl pyrollidone K-30 and 89 16 0000135684 00000 n Dexamethasone-Water Soluble has been used as a component of • Dulbecco′s modified Eagle medium based osteogenic and adipogenic medium for human mesenchymal stem cell culture • erythroid expansion media for the growth of liver, bone marrow and spleen tissues • medium 199 (M199) for hepatocyte culture. 0000135754 00000 n trailer It was in the same range as the solubility of the disodium salt xref
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(ed.).
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0000007194 00000 n The IDR of the new phases were much faster compared with acyclovir, particularly at neutral pH. 0000104307 00000 n endstream endobj 992 0 obj <>/Filter/FlateDecode/Index[60 882]/Length 49/Size 942/Type/XRef/W[1 1 1]>>stream
Correlation between solubility and pH could not be established. 0000004230 00000 n 0000002029 00000 n h���S��ڗ��r_7�p��j}4/��D��������+fg �#iP�����< 0000004654 00000 n 0000001161 00000 n 0000028819 00000 n
0000001607 00000 n 0000002186 00000 n 0000071766 00000 n �! 0000000016 00000 n 0000002904 00000 n Herpes drug.2 Although widely used, neutral acyclovir suffers from limited solubility in water (1.2−1.6 mg/mL at 22−25 °C3,4), and its absorption into the gastrointestinal tract is only 10−30% of an oral dose, with the low systemic bioavailability being a result of this limited aqueous solubility and low
We do not recommend storing the aqueous solution for more than one day. %PDF-1.4 %���� 0000008078 00000 n 0000028033 00000 n
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FTIR, DSC and
0000190721 00000 n h�b```b``;���� �� Ā B@16� These dependences are shown in Fig. The effect of two excipients (PVP K-30 and nicotinamide) was investigated on the 0000001025 00000 n 0000006618 00000 n
%%EOF 0000104244 00000 n 942 52 trailer 0000003297 00000 n XRPD data confirmed the formation of inclusion complexes. 0000001362 00000 n
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0000016726 00000 n solubility of acyclovir in PBS, pH 7.2, is approximately 0.2 mg/ml. 0000000627 00000 n 0000167168 00000 n
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This problem can be resolved by enhancing the solubility and hence dissolution of poorly water soluble drug acyclovir. The DSC explained and correlated the change in the endothermic
0000143984 00000 n
Novel water-soluble prodrugs of acyclovir cleavable by the dipeptidyl-peptidase IV (DPP IV/CD26) enzyme Eur J Med Chem. nicotinamide) using the kneading method. 0000004377 00000 n 0000005823 00000 n 0000000016 00000 n
xref 0000185574 00000 n
0000107314 00000 n 0000014035 00000 n 0000001620 00000 n endstream endobj 943 0 obj <>/Metadata 58 0 R/PageLabels 55 0 R/Pages 57 0 R/StructTreeRoot 60 0 R/Type/Catalog/ViewerPreferences<>>> endobj 944 0 obj <>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/Rotate 0/StructParents 5/TrimBox[0.0 0.0 595.3 793.7]/Type/Page>> endobj 945 0 obj <> endobj 946 0 obj <> endobj 947 0 obj <> endobj 948 0 obj <> endobj 949 0 obj <> endobj 950 0 obj <> endobj 951 0 obj <> endobj 952 0 obj <> endobj 953 0 obj <> endobj 954 0 obj <>stream 0000185535 00000 n 0000003620 00000 n as compared to that of PVP K-30. 104 0 obj<>stream (15-30%), low permeability (across the gastro intestinal membrane) and short half-life (3 hours) leading to high dosage solubility, dissolution and permeability of acyclovir.
0000006991 00000 n The water-solubility of product 7 (MSX-4) was determined by UV spectroscopy and found to be 7.3 mg/mL (13.8 mM), which is extraordinarily high compared to most if not all high affinity adenosine receptor A2A antagonists [17].
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The inclusion complexes of acyclovir 0000103549 00000 n %%EOF 0000141989 00000 n
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