Read and follow the instructions carefully. i've NEVER seen him suggest bica rectally??!

reported a ≥50% PSA decline rate in 7/31 patients (22.5%), overall duration of response 4 months (3–13+ months). Bicalutamide is contraindicated in children and adolescents. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.Using bicalutamide with any of the following medicines is usually not recommended, but may be required in some cases. By continuing you agree to the Copyright © 2020 Elsevier B.V. or its licensors or contributors. These medications are not usually taken together.

Renal impairment Workup revealed acutely elevated liver transaminases (> 5 times the upper limit of normal), alkaline phosphatase, conjugated hyperbilirubinemia, and coagulopathy. It is best to read this information with our general information about hormonal therapies and the type of cancer you have..

I'm sorry I can't help you with withdrawal Pierre , but I'd love to hear how you think it affected you mentally and physically. In these cases, your doctor may want to change the dose, or other precautions may be necessary. If you plan to have children, talk with your doctor before using this medicine. Ask your doctor if you have questions.It is best to take bicalutamide at the same time each day, in the morning or in the evening.Bicalutamide should be started at the same time as treatment with a luteinizing hormone-releasing hormone (LHRH) analog (eg, goserelin, leuprolide, Lupron®, or Zoladex®). Enzalutamide is an oral androgen receptor signalling inhibitor, which acts at three distinct levels of the signalling pathway: (1) it is a pure androgen receptor antagonist and completely inhibits binding of androgens to cytosolic androgen receptors in prostate cells; (2) it inhibits nuclear translocation of activated receptors; (3) it inhibits the association of the activated androgen receptor with DNA [In the AFFIRM study enzalutamide the overall incidences of adverse events were comparable to placebo [A 47-year-old man who had been using finasteride for male pattern alopecia for 4 years developed bilateral anterior subcapsular cataracts and had phacoemulsification and insertion of intraocular lenses; both eyes showed features of IFIS, including prolapse and undulation of the iris and pupil constriction [A 56-year-old man developed tense blisters on his hands and feet, with multiple erythematous plaques with crusting and scaling and multiple round pink scars.
Bicalutamide should be started at the same time as treatment with a luteinizing hormone-releasing hormone (LHRH) analog (eg, goserelin, leuprolide, Lupron®, or Zoladex®).

The tissue distribution of bicalutamide is not well-characterized. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.The presence of other medical problems may affect the use of bicalutamide. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Make sure you tell your doctor if you have any other medical problems, especially:Bicalutamide should come with a patient information leaflet.

i'm pretty sure it's described in his v6 powerpoint. ... getting fatter.

This medicine should be started at the same time as treatment with a luteinizing hormone-releasing hormone (LHRH) analog (eg, goserelin, leuprolide, Lupron®, or Zoladex®). Although it takes a long time for bicalutamide to reach steady-state concentrations, it appears to have antiandrogenic efficacy equivalent to that of flutamide (which has a much shorter elimination half-life and reaches steady-state levels much faster) by the end of the first day of treatment. It may also cause birth defects if the father is using it when his sexual partner becomes pregnant. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes.Mayo Clinic does not endorse companies or products. You may take this medicine with food or on an empty stomach.