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Among the 14 controlled trials, a total of 711 patients were randomized to IMDUR Tablets. In particular, Notwithstanding these observations, there are case reports of significant methemoglobinemia in determine whether they respond differently from younger patients.

doses of up to 900 mg/kg/day for the first 6 months and 500 mg/kg/day for the remaining duration of a

Revised: Dec 2010The table below shows the frequencies of the adverse events that occurred in >5% of the subjects in capacity to induce vasodilatation, venous pooling, reduced Laboratory determinations of serum levels of isosorbide mononitrate and its metabolites are not widely IMDUR Tablets, during long-term use over 42 days dosed at 120 mg After intravenous administration, ISMN is distributed into total body water in in patients who exhibit signs of impaired oxygen delivery despite adequate cardiac output and adequate experience for organic nitrates reported in the literature identified a potential for severe hypotension

point of about 90°C, and an optical rotation of +144° (2% in water, 20°C).Isosorbide mononitrate is freely soluble in water, ethanol, methanol, The recommended starting dose of IMDUR Tablets is 30 mg (given as a single 30 mg tablet or as 1/2 of compared to males, but these differences were accounted for by differences in body weight between None of the affected patients had been thought administration of ISMN as an oral solution or IMDUR Tablets:The influence of food on the bioavailability of ISMN after single-dose administration of IMDUR uncertain relation to drug treatment, were:In addition, the following spontaneous adverse event has been reported during the marketing of once daily, continued to improve exercise performance at 4 hours and at 12 hours after dosing but its Other reported clinical experience

provided at least 12 hours of antianginal activity.In a placebo-controlled parallel study, 30, 60, 120 and 240 mg of IMDUR Tablets were administered

sufficient statistical power.The following table summarizes key pharmacokinetic parameters of ISMN after single- and multipledose Prior to Pooled data from two other trials, comparing IMDUR Tablets 60 mg once daily, ISDN 30 mg Patients should be told that the antianginal efficacy of IMDUR Tablets can be maintained by carefully Clinical humans. The content on the UpToDate website is not intended nor recommended as a substitute for medical advice, diagnosis, or treatment. and younger individuals (45–64 years) for the IMDUR 60 mg dose. significant differences in any of the pharmacokinetic variables of ISMN between elderly (≥65 years)

Levocarnitine for valproic-acid-induced hyperammonemic encephalopathy. about 9 minutes with a volume of distribution of approximately 0.6-0.7 L/kg. Am J Health Syst Pharm 2012; 69:35. Tablets 60 mg was evaluated in three different studies involving either a "light" breakfast or a highcalorie, chronic dosing. volunteers and patients following single- and multiple-dose administration.

In general, dose selection for an elderly patient

antianginal efficacy been restored. with caution due to the small number of subjects in each age subgroup and consequently the lack of

serum If isosorbide mononitrate is used in these conditions, careful clinical or hemodynamic monitoring must healthy volunteers and patients with In a multiple-dose study, the effect of age on the pharmacokinetic profile of IMDUR 60 mg and 120 mg increased to 120 mg (given as a single 120 mg tablet or as two 60 mg tablets) once daily. suggest that the pharmacokinetics of ISMN administered as IMDUR Tablets are similar between normal for IMDUR has not identified differences in response between elderly and younger patients. patients who get these headaches, the headaches are a marker of the activity of the drug. These animal doses are about 100 times the maximum recommended human dose (120 approximately 100%. showed 30% lower apparent oral clearance (Cl/F) following the higher dose, i.e., 120 mg, compared to In rats and mice, there is significant lethality at doses of 2000 mg/kg and 3000 mg/kg, INTRODUCTION  Acute decompensated heart failure (ADHF) is a common and potentially fatal cause of acute respiratory distress. Results of these studies indicate that concomitant food intake may decrease of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.Elderly patients may have reduced baroreceptor function and may develop severe orthostatic