(Reuters Health) - - Nearly one in 10 cancer patients treated with chemotherapy or newer targeted drugs may be hospitalized for serious kidney injury, a Canadian study suggests.The study involved roughly 163,000 patients who started chemotherapy or targeted therapies for a new cancer diagnosis in Ontario from 2007 to 2014. Are there factors supporting organic renal failure such as proteinuria, hematuria, leukocyturia, anemia or hemolysis? The medical team first suspected Cisplatin nephrotoxicity, therefore the chemotherapy protocol was changed, and only Pemetrexed and Bevacizumab were maintained from June 2014 at the same doses. Immunofluorescence staining was negativeThe renal function did not recover. Clinical trial of highdose methotrexate (NSC-740) with citrovorum factor (NSC-35%)-Toxicologic and therapeutic observations. Semin Nephrol. Intern Med J.
N Engl J Med. J Oncol Pharm Pract. Nephrol Dial Transplant. Acute granuloma- tous tubulointerstitial nephritis caused by intravesical BCG.
Pemetrexed, a multitargeted antifolate cytotoxic agent, is currently used primarily in combination with cisplatin for metastatic non-small cell lung cancer and for malignant mesothelioma. Pemetrexed (Alimta): improving outcome in malignant pleural mesothelioma. They are below the ribcage near the middle of the back. 2007;34:378–9.Hill PA, Prince HM, Power DA. Am J Med. Path- ology. 2015;108:1–6.Pitman SW, Parker LM, Tattersall MHN, et al. You can also search for this author in Curr Protoc Immunol.
We also discuss the benefits of renal biopsy in helping to diagnose drug-induced renal toxicity.A 66-year-old woman was admitted in March 2015 to Pitié Salpêtrière Hospital for rapidly progressive kidney failure. 2014;370(13):1270–1.Al Aly Z, Philocet Ashley JM, Gellens ME, Gonzalez E. Thrombotic thrombocytopenic Purpura in a patient treated with Imatinib Mesylate: true association or mere coincidence? Am J Geriatr Pharmacother. 2005;20:849–50.Modesto A, Marty L, Suc JM, et al. 2005;32:16–22.Brandes JC, Grossman SA, Ahmad H. Alteration of Pemetrexed excretion in the presence of acute renal failure and effusions: presentation of a case and review of the literature. adequate hydration, dose adjustments) [As with cisplatin, pemetrexed causes tubular toxicity, whereas gemcitabin and bevacizumab induce vascular defects [The effects of bevacizumab are different. In final kidney failure stages of death, medications and measures are taken to prevent further damage of kidneys and to limit adverse reactions of kidney failure on the body. 2014;Scagliotti GV, Gandara D, et al. Overall, 10,880 were hospitalized with serious kidney damage or for dialysis.This translated into a cumulative acute kidney injury rate of 9.3 percent, the study found.People with advanced tumors were 41 percent more likely to have acute kidney injuries than patients with early-stage cancer.Compared to the group as a whole, individuals who already had chronic kidney disease were 80 percent more likely to be hospitalized for a kidney injury, and people with diabetes had a 43 percent greater chance.“Patients should be aware that kidney injury can result during cancer treatment - both due to cancer itself and the drugs used to treat it,” said lead study author Dr. Abhijat Kitchlu of the University of Toronto.Many medicines that treat tumors are removed from the body by the kidneys and can damage certain cells within the kidneys, Kitchlu said by email.“It may be possible to reduce the risk of acute kidney injury by maintaining good hydration and in some cases, avoiding other drugs that can increase risk to the kidneys,” Kitchlu added. Am J Kidney Dis. Cancer Chemother Rep. 1975;6(suppl):43–9.Perazella MA, Moeckel GW. J Clin Oncol. N Engl J Med.
N Engl J Med. J Oncol Pharm Pract. Nephrol Dial Transplant. Acute granuloma- tous tubulointerstitial nephritis caused by intravesical BCG.
Pemetrexed, a multitargeted antifolate cytotoxic agent, is currently used primarily in combination with cisplatin for metastatic non-small cell lung cancer and for malignant mesothelioma. Pemetrexed (Alimta): improving outcome in malignant pleural mesothelioma. They are below the ribcage near the middle of the back. 2007;34:378–9.Hill PA, Prince HM, Power DA. Am J Med. Path- ology. 2015;108:1–6.Pitman SW, Parker LM, Tattersall MHN, et al. You can also search for this author in Curr Protoc Immunol.
We also discuss the benefits of renal biopsy in helping to diagnose drug-induced renal toxicity.A 66-year-old woman was admitted in March 2015 to Pitié Salpêtrière Hospital for rapidly progressive kidney failure. 2014;370(13):1270–1.Al Aly Z, Philocet Ashley JM, Gellens ME, Gonzalez E. Thrombotic thrombocytopenic Purpura in a patient treated with Imatinib Mesylate: true association or mere coincidence? Am J Geriatr Pharmacother. 2005;20:849–50.Modesto A, Marty L, Suc JM, et al. 2005;32:16–22.Brandes JC, Grossman SA, Ahmad H. Alteration of Pemetrexed excretion in the presence of acute renal failure and effusions: presentation of a case and review of the literature. adequate hydration, dose adjustments) [As with cisplatin, pemetrexed causes tubular toxicity, whereas gemcitabin and bevacizumab induce vascular defects [The effects of bevacizumab are different. In final kidney failure stages of death, medications and measures are taken to prevent further damage of kidneys and to limit adverse reactions of kidney failure on the body. 2014;Scagliotti GV, Gandara D, et al. Overall, 10,880 were hospitalized with serious kidney damage or for dialysis.This translated into a cumulative acute kidney injury rate of 9.3 percent, the study found.People with advanced tumors were 41 percent more likely to have acute kidney injuries than patients with early-stage cancer.Compared to the group as a whole, individuals who already had chronic kidney disease were 80 percent more likely to be hospitalized for a kidney injury, and people with diabetes had a 43 percent greater chance.“Patients should be aware that kidney injury can result during cancer treatment - both due to cancer itself and the drugs used to treat it,” said lead study author Dr. Abhijat Kitchlu of the University of Toronto.Many medicines that treat tumors are removed from the body by the kidneys and can damage certain cells within the kidneys, Kitchlu said by email.“It may be possible to reduce the risk of acute kidney injury by maintaining good hydration and in some cases, avoiding other drugs that can increase risk to the kidneys,” Kitchlu added. Am J Kidney Dis. Cancer Chemother Rep. 1975;6(suppl):43–9.Perazella MA, Moeckel GW. J Clin Oncol. N Engl J Med.