Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take this medicinal product.Prior to the use of Dexamethasone in combination with any other medicinal product, reference should be made to the Summary of Product Characteristics of that product.Patients taking NSAIDs should be monitored, as NSAIDs may increase the incidence and/or severity of gastric ulcers. Even in cases of prolonged adrenocortical insufficiency after discontinuation of treatment, the administration of glucocorticoids can be necessary in physically stressful situations. The tablets can be divided into equal halves and can provide additional 2 mg and 10 mg strengths and make it easier for the patient to swallow the tablet.When alternate-day therapy is not possible, the entire daily dose of glucocorticoid can usually be administered as a single morning dose; however, some patients will require divided daily doses of glucocorticoids.Hypersensitivity to the active substance or to any of the excipients listed in section 6.1.Systemic infection unless specific anti-infective therapy is employed.Vaccination with live vaccines during treatment with large therapeutic doses of dexamethasone (and other corticosteroids) is contraindicated due to the possibility of viral infection (see section 4.4 and 4.5).An adrenocortical insufficiency, which is caused by glucocorticoid treatment, can, depending on the dose and length of treatment, remain for many months, and in some cases more than a year, after discontinuation of treatment. Corticosteroids should only be administered to patients with suspected or identified pheochromocytoma after an appropriate risk/benefit evaluation.Corticosteroids cause a dose-dependent inhibition of growth in infancy, childhood, and adolescence since corticosteroids may give rise to early closing of the epiphyses, which may be irreversible. It is practically insoluble in water. Sign in here to access free tools such as favourites and alerts, or to access personal subscriptionsIf you have access to journal content via a university, library or employer, sign in hereResearch off-campus without worrying about access issues. A list of US medications equivalent to Decadron is available on the Drugs.com website. Published studies provide evidence of efficacy and safety in pediatric patients for the treatment of nephrotic syndrome (patients >2 years of age), and aggressive lymphomas and leukemias (patients >1 month of age). If required, the dexamethasone dose should be reduced.Ketoconazole may not only increase the plasma concentration of dexamethasone by inhibition of CYP3A4, but also suppress adrenal corticosteroid synthesis and cause adrenal insufficiency upon discontinuation of corticosteroid treatment.Estrogens, including oral contraceptives, may inhibit the metabolism of certain corticosteroids and thus enhance their effect.Dexamethasone is a moderate inducer of CYP3A4. Naturally occurring glucocorticoids (hydrocortisone and cortisone), which also have sodium-retaining properties, are used as replacement therapy in adrenocortical deficiency states. This information is intended for use by health professionalsEach tablet contains 77.9 mg lactose (as lactose monohydrate).White or almost white, round tablets with bevelled edges and scored on one side (Thickness: 2.5-3.5 mm; Diameter: 5.7-6.3 mm). Infection with any pathogen (viral, bacterial, fungal, protozoan or helminthic) in any location of the body may be associated with the use of corticosteroids alone or in combination with other immunosuppressive agents.These infections may be mild to severe.

Steroid side effects are more likely in the very young and very old. All corticosteroids increase calcium excretion.Literature reports suggest an apparent association between use of corticosteroids and left ventricular free wall rupture after a recent myocardial infarction; therefore, therapy with corticosteroids should be used with great caution in these patients.Corticosteroids can produce reversible hypothalamic-pituitary-adrenal (HPA) axis suppression with the potential for corticosteroid insufficiency after withdrawal of treatment. This, together with a decrease in the protein matrix of the bone secondary to an increase in protein catabolism, and reduced sex hormone production, may lead to inhibition of bone growth in pediatric patients and the development of osteoporosis at any age. Usually they start within a few days or weeks of starting the medicine. There have been cases reported in which concomitant use of amphotericin B and hydrocortisone was followed by cardiac enlargement and congestive heart failure (see Latent disease may be activated or there may be an exacerbation of intercurrent infections due to pathogens, including those caused by It is recommended that latent amebiasis or active amebiasis be ruled out before initiating corticosteroid therapy in any patient who has spent time in the tropics or any patient with unexplained diarrhea.Similarly, corticosteroids should be used with great care in patients with known or suspected Strongyloides (threadworm) infestation. The contribution of the underlying disease and/or prior corticosteroid treatment to the risk is also not known.