The dosage should be gradually reduced over a period of 1 to 2 weeks and the patient should be carefully monitored when discontinuing chronic therapy. DDAVP (desmopressin acetate) is an antidiuretic and antihemorrhagic drug used to treat bed-wetting, central cranial diabetes insipidus, and increased thirst and urination caused by head surgery or head trauma. These medications are not usually taken together. Psychiatric side effects have included a single case of paranoid psychosis associated with the use of DDAVP nasal spray.1. 5 DDAVP ® /Desmopressin Injection is indicated as follows :. Sweeney JD, Hoernig LA, Behrens AN, Novak E, Swank RT "von Willebrand's variant (type II Buffalo). Explore More Sites At least one case of fatal left coronary thrombosis has been associated with the use of DDAVP.Nervous system side effects have included seizures and/or coma as a result of severe water intoxication and hyponatremia.

Kallio J, Rautava P, Huupponen R, Korvenranta H "Severe hyponatremia caused by intranasal desmopressin for nocturnal enuresis." Odeh M, Oliven A "Coma and seizures due to severe hyponatremia and water intoxication in an adult with intranasal desmopressin therapy for nocturnal enuresis."

This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.Things to remember when you fill your prescription.WebMD does not provide medical advice, diagnosis or treatment. Although not all of these side effects may occur, if they do occur they may need medical attention.Some side effects of desmopressin may occur that usually Check with your health care professional if any of the following side effects One review of the literature found that the incidence of thrombotic events associated with the use of Cardiovascular side effects have infrequently included transient and slight elevations or reductions in blood pressure, a compensatory change in heart rate, and facial flushing with injections of desmopressin (DDAVP). Contact your institution's library to ask if they subscribe to McGraw-Hill Medical Products. View Mannucci PM, Lusher JM "Desmopressin and thrombosis." Sun HL, Chien CC "Thrombocytopenia and subdural hemorrhage after desmopressin administration." Available for Android and iOS devices. Other nervous system side effects have included headache and dizziness in less than 3% of patients. 3. If your institution subscribes to this resource, and you don't have a MyAccess Profile, please contact your library's reference desk for information on how to gain access to this resource from off-campus. Apnea and Gastrointestinal side effects have included mild abdominal cramps and nausea in 2% of patients. Israels SJ, Kobrinsky NL "Serious reaction to desmopressin in a child with cyanotic heart disease." This site uses cookies to provide, maintain and improve your experience. Am J Hematol 43 (1993): 5-945. There have been rare reports of thrombotic events (acute cerebral thrombosis, acute myocardial infarction) in some patients after DDAVP injection.

Lancet 2 (1981): 808Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.Some side effects may not be reported. Ann Intern Med 103 (1985): 9626. DDAVP is available in generic form. Am J Hematol 44 (1993): 12-536. Lancet 1 (1982): 10847. Look up information on diseases, tests, and procedures; then consult the database with 5,000+ drugs or refer to 65,000+ dictionary terms. Vermylen J, Peerlinck K "Fatal complication of desmopressin." McLeod BC "Myocardial infarction in a blood donor after administration of desmopressin." Common side effects of DDAVP include:

Desmopressin is a man-made form of a hormone that occurs naturally in the pituitary gland. Williford SL "Water intoxication in patients treated with desmopressin - reply."
Forest Pharmaceuticals, St. Louis, MO. Decreased frequency of attacks of angina pectoris.

DDAVP nasal spray has been infrequently associated with somnolence, The risk factors for DDAVP-induced hyponatremia include Hematologic side effects have included platelet aggregation and Local side effects of injections of DDAVP have included intravenous site Respiratory side effects of intranasal DDAVP have included rhinitis, epistaxis, and nostril pain in 2% to 10% of patients. Arrhythmias, pulmonary edema-Monitor for arrhythmias and assess breath sounds. Harris AS "Clinical experience with desmopressin: efficacy and safety in central diabetes insipidus and other conditions." Instruct patient to report other bothersome side effects such as severe or prolonged nasal congestion (when administered intranasally), skin reactions (flushing), or GI problems (nausea, abdominal cramps). Robson WLM "Water intoxication in patients treated with desmopressin." DDAVP is also used to treat bleeding due to platelet dysfunction. Holmberg L, Nilsson IM, Borge L, Gunnarsson M, Sjorin E "Platelet aggregation induced by 1-desamino-8-D-arginine vasopressin (DDAVP) in Type IIB von Willebrand's disease." Hjalmas K, Bengtsson B "Efficacy, safety, and dosing of desmopressin for nocturnal enuresis in Europe."
Check with your doctor immediately if any of the following side effects occur: Am Fam Physician 42 (1990): 1051-722. Lancet 336 (1990): 1137-823. Vasodilation and water retention have occurred. Sukhai RN "Enuresis nocturna: long term use and safety aspects of minrin (desmopressin) spray." "Product Information. Pharmacotherapy 8 (1988): 94-98.