Acetazolamide, sold under the trade name Diamox among others, is a medication used to treat glaucoma, epilepsy, altitude sickness, periodic paralysis, idiopathic intracranial hypertension (raised brain pressure of unclear cause), and heart failure. Select one or more newsletters to continue. caution should be exercised in all patients with chronic renal failure who require Applies to: GoutUric acid excretion is decreased during therapy with carbonic anhydrase inhibitors, and gout may be exacerbated. Extreme caution should be exercised if carbonic anhydrase inhibitors are administered to patients with these preexisting conditions.
Alkalinization of the urine and promotion of diuresis are thus affected.
The diuretic effect of DIAMOX is due to its action in the kidney on the reversible reaction involving hydration of carbon dioxide and dehydration of carbonic acid. acetazolamide. Major Potential Hazard, Moderate plausibility. Carbonic anhydrase inhibitors increase the risk of developing hepatic encephalopathy in these patients.
If signs of hypersensitivity or other serious reactions occur, discontinue use of this drug.Caution is advised for patients receiving concomitant high-dose aspirin and DIAMOX, as anorexia, tachypnea, lethargy, metabolic acidosis, coma, and death have been reported.Increasing the dose does not increase the diuresis and may increase the incidence of drowsiness and/or paresthesia. Since acetazolamide is a sulfonamide derivative, cross sensitivity between acetazolamide, sulfonamides and other sulfonamide derivatives is possible.Acetazolamide therapy is contraindicated in situations in which sodium and/or potassium blood serum levels are depressed, in cases of marked kidney and liver disease or dysfunction, in suprarenal gland failure, and in hyperchloremic acidosis. 2002
2002 The diuretic effect of DIAMOX is due to its action in the kidney on the reversible reaction involving hydration of carbon dioxide and dehydration of carbonic acid. Select one or more newsletters to continue. and formulary information changes. Diseases & Conditions If you log out, you will be required to enter your username and password the next time you visit. The result is renal loss of HCO 3 ion, which carries out sodium, water, and potassium. Dehydration, hypotension, If rapid ascent is undertaken and DIAMOX is used, it should be noted that such use does not obviate the need for prompt descent if severe forms of high altitude sickness occur, i.e., high altitude pulmonary edema (HAPE) or high altitude cerebral edema.Caution is advised for patients receiving concomitant high-dose aspirin and DIAMOX, as anorexia, tachypnea, lethargy, metabolic acidosis, coma, and death have been reported (see Both increases and decreases in blood glucose have been described in patients treated with acetazolamide. Electrolyte imbalance, development of an acidotic state, and central nervous system effects might be expected to occur.
There are no adequate and well-controlled studies in pregnant women. 1992© 1993 National Kidney Foundation, Inc. Pulmonary function (e.g., minute ventilation, expired vital capacity, and peak flow) is greater in the DIAMOX treated group, both in subjects with AMS and asymptomatic subjects.
It may be necessary to adjust the dose, but it has usually been found that dosage in excess of 2 capsules (1 g) does not produce an increased effect.
By decreasing the gastrointestinal absorption of primidone, DIAMOX may decrease serum concentrations of primidone and its metabolites, with a consequent possible decrease in anticonvulsant effect. Extreme caution should be exercised if carbonic anhydrase inhibitors is administered to these patients.Major Potential Hazard, Moderate plausibility.
To read, Please