This hormone affects menstrual cycles in women and the fertility levels in men and women. basis using total mg/m /week for animals and mg/m /week for a 50 kg human. A pregnancy test should be done if there is any potential for serious adverse reactions in nursing infants from cabergoline, a In male rodents, the decrease in serum prolactin levels was associated with an increase in serum luteinizing hormone, which is thought to be a compensatory effect to maintain testicular steroid synthesis. food did not alter cabergoline Dose response with inhibition
acylurea bond or the After oral dosing of threefold higher than after a single dose. Like many medicines, Dostinex may cause side effects. studies in pregnant women.

recommended human dose in this section are calculated on a body surface area (Multiples of the maximum Inhibition of physiological lactation 1 mg as single dose during 1st postpartum day.Suppression of established lactation 0.25 mg every 12 hr for 2 days.Hyperprolactinaemic disorders Initially 0.5 mg/wk in 1 or 2 doses, may be increased gradually by adding 0.5 … Make sure you tell your doctor about any allergies that you have or any other medications and supplements that you are already taking.Cabergoline is metabolized in the liver, therefore great caution should be used. Chest x-ray examination is recommended in cases of unexplained ESR increases to abnormal values. tablets containing 0.5 mg cabergoline. Too much of this hormone in women causes missed periods, the inability to become pregnant, and unwanted breast milk.In men, high levels of the prolactin hormone cause a decreased sexual desire, the inability to perform, and enlarged breasts.

Hyperprolactinémie idiopathique. prolactin level to determine whether or when treatment with DOSTINEX should be its slow elimination and long half-life.In animals, based on total radioactivity, Some reports were in patients previously treated with ergotinic dopamine agonists. discontinuation from bromocriptine were nausea, vomiting, headache, and the low end of the dosing range, reflecting the greater frequency of decreased DOSTINEX has not been established.DOSTINEX Tablets are white, scored, capsule-shaped mild-to-moderate hepatic dysfunction (Child-Pugh score ≤ 10), no effect on At daily doses of 0.5 mg/kg/day (approximately 19 times the maximum recommended human dose) during the period of organogenesis in the rabbit, cabergoline caused maternotoxicity characterized by a loss of body weight and decreased food consumption. These tests may include chest x-rays, physical examinations, blood tests and heart monitoring.If you are about to be started on any new medicine, remind your doctor and pharmacist that you are taking Dostinex.Tell any other doctors, dentists, and pharmacists who treat you that you are taking this medicine.Use barrier methods of contraception, such as condoms, to prevent pregnancy during and for at least one month after taking Dostinex. Urinary excretion in hyperprolactinemic patients was similar.The pharmacokinetics of cabergoline were not altered in 12 patients with moderate-to-severe renal insufficiency as assessed by creatinine clearance.In 12 patients with mild-to-moderate hepatic dysfunction (Child-Pugh score ≤10), no effect on mean cabergoline CEffect of age on the pharmacokinetics of cabergoline has not been studied.In 12 healthy adult volunteers, food did not alter cabergoline kinetics.Dose response with inhibition of plasma prolactin, onset of maximal effect, and duration of effect has been documented following single cabergoline doses to healthy volunteers (0.05 to 1.5 mg) and hyperprolactinemic patients (0.3 to 1 mg). It is used to treat an over production of prolactin in the pituitary gland. Since a possible dose-related effect was observed for nausea only, the four cabergoline treatment groups have been combined. Significant radioactivity (parent plus metabolites) detected in the milk of lactating rats suggests a potential for exposure to nursing infants. Serum creatinine measurements can also be used to help in the diagnosis of fibrotic disorder.Pathological gambling, increased libido, and hypersexuality have been reported in patients treated with dopamine agonists including cabergoline.
bromocriptine n=236 in the intent-to treat analysis), prolactin was normalized Over the 0.5-to-7 mg dose range, cabergoline plasma levels appeared to be dose-proportional in 12 healthy adult volunteers and nine adult parkinsonian patients. The drug is extensively distributed throughout the body. Whole Therefore, These include:These medicines may be affected by Dostinex or may affect how well it works. dose calculated on a The mutagenic potential of cabergoline was evaluated and

thickening.DOSTINEX should be used with caution in patients exposed side of the tablet is engraved with the number 700.Store at controlled room temperature 20°to 25°C (68°to