If there is evidence of CAD or coronary artery vasospasm, Imitrex Injection is contraindicated. I think they actually came from Europe. The generic, sumitriptan, is cheaper but still expensive. For such patients, consider periodic cardiovascular evaluation in intermittent long-term users of Imitrex Injection.Life-threatening disturbances of cardiac rhythm, including ventricular tachycardia and ventricular fibrillation leading to death, have been reported within a few hours following the administration of 5-HTSensations of tightness, pain, pressure, and heaviness in the precordium, throat, neck, and jaw commonly occur after treatment with Imitrex Injection and are usually non-cardiac in origin. Apprise patients of the importance of this follow-up Inform patients that anaphylactic reactions have occurred in patients receiving Imitrex Injection. A second 6-mg dose should only be considered if some response to a first injection was observed.An autoinjector device (IMITREX STATdose Pen) is available for use with 4-mg and 6-mg prefilled syringe cartridges.

Ask your prescription plan if they have an appeals process which will allow more. The osmolality of both injections is 291 mOsmol.Sumatriptan binds with high affinity to human cloned 5-HTSignificant elevation in blood pressure, including hypertensive crisis, has been reported in patients with and without a history of hypertension In healthy volunteers (N = 18), a trial evaluating the effects of sumatriptan on peripheral (small vessel) arterial reactivity failed to detect a clinically significant increase in peripheral resistance.Transient increases in blood pressure observed in some patients in clinical trials carried out during sumatriptan’s development as a treatment for migraine were not accompanied by any clinically significant changes in heart rate.The bioavailability of sumatriptan via subcutaneous site injection to 18 healthy male subjects was 97% ± 16% of that obtained following intravenous injection.After a single 6-mg subcutaneous manual injection into the deltoid area of the arm in 18 healthy males (age: 24 ± 6 years, weight: 70 kg), the maximum serum concentration (CProtein binding, determined by equilibrium dialysis over the concentration range of 10 to 1,000 ng/mL is low, approximately 14% to 21%. Keep a list of them to show your healthcare provider or pharmacist when you get a new medicine.IMITREX can cause dizziness, weakness, or drowsiness.

In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function and of concomitant disease or other drug therapy.A cardiovascular evaluation is recommended for geriatric patients who have other cardiovascular risk factors (e.g., diabetes, hypertension, smoking, obesity, strong family history of CAD) prior to receiving Imitrex Injection Coronary vasospasm was observed after intravenous administration of Imitrex Injection The elimination half-life of sumatriptan is about 2 hours It is unknown what effect hemodialysis or peritoneal dialysis has on the serum concentrations of sumatriptan.Imitrex Injection contains sumatriptan succinate, a selective 5-HTImitrex Injection is a clear, colorless to pale yellow, sterile, nonpyrogenic solution for subcutaneous injection. 5, 10, or 20 mg into 1 nostril as a single dose. Sumatriptan injections and Sumavel DosePro systems: The maximum single recommended adult dose is 6 mg given subcutaneously. Intranasal dosage (Imitrex nasal spray and generic equivalents) Adults. The reported rate of major birth defects among deliveries to women with migraine ranged from 2.2% to 2.9% and the reported rate of miscarriage was 17%, which were similar to rates reported in women without migraine.In a study using data from the Swedish Medical Birth Register, live births to women who reported using triptans or ergots during pregnancy were compared with those of women who did not. The frequency of all adverse reactions in these patients appeared to be both dose- and age‑dependent, with younger patients reporting reactions more commonly than older pediatric patients.Postmarketing experience documents that serious adverse reactions have occurred in the pediatric population after use of subcutaneous, oral, and/or intranasal IMITREX.