Therefore, it cannot be excluded that our findings are influenced by selection bias. A few patients reported manifestations in skin such as oral mucosal discolouration, cutaneous lichenoid eruption, skin exfoliation and alopecia. Our general interest e-newsletter keeps you up to date on a wide variety of health topics.Along with its needed effects, a medicine may cause some unwanted effects. A total of 29 of 181 (16%) patients were symptomatic at the time of enquiry, and there was no difference in ingested LT dose between asymptomatic and symptomatic patients, neither in children nor in adults (age 16–92 years) (When and how to treat levothyroxine (LT), T4, poisoning is controversial and the risk of exposure weighted against gastrointestinal decontamination (GID) has been discussed Despite higher mean LT and triiodothyronine (T3) levels in children compared with adults, serious symptoms are less frequently seen in children The risk of late‐onset symptoms and the fact that LT poisoning in some cases has been associated with severe outcome make it difficult to prepare general clinical guidelines, for example in relation to a safe clinical observation level. An overdose of thyroid medication increases heart rate, according to eMedTV.com 1⭐⭐This is a verified and trusted source Goto Source . However, simultaneous intake of multiple concomitant drugs and coexisting disease should be considered as risk factors.Because of inadequate information at the DPIC database concerning comorbidity (thyroid diagnosis), the frequency, severity and impact of possible chronic LT poisoning and/or hyperthyroidism/hypothyroidism were difficult to obtain.We are grateful to nurse Lotte Lydeking for her assistance in extracting data from the DPIC database, and we also thank Aspen Pharma Trading Limited for the use of data.The authors report no conflict of interests. Get emergency help immediately if any of the following symptoms of overdose occur: Symptoms of overdose Change in consciousness cold, clammy skin confusion disorientation fast or weak pulse lightheadedness loss of cardiac symptoms insomnia if take too much or overdose Side Effects irritability, nervousness, insomnia, tachycardia, nausea, weight loss, sweating, fever, leg cramps, heat intolerance. When contacting children who ingested LT up to years ago, some levels of recall bias must exist.Finally, the clinical effect of LT poisoning is increasing the catecholamine activity leading to sympathomimetic clinical manifestations, which makes it difficult to distinguish common causes such as nervousness and anxiety which might result in an overestimation of the clinical impact of LT poisoning.In summary, the clinical outcome of LT poisoning is often benign, and accidental intake of LT in moderate doses does not require clinical monitoring or GID. All rights reserved.

We also investigated late‐onset symptoms, the influence of multiple drug ingestion and GID on clinical outcome.

By continuing to browse this site, you agree to its use of cookies as described in our I have read and accept the Wiley Online Library Terms and Conditions of UseRaising the decontamination level for thyroid hormone ingestionsMassive levothyroxine overdose: high anxiety–low toxicityBenign course after massive levothyroxine ingestionMinor signs and symptoms of toxicity in a young woman in spite of massive thyroxine ingestionLevothyroxine ingestions in children: an analysis of 78 casesSodium levothyroxine (Synthroid R) intoxication in a childLevothyroxine overdose associated with seizures in a young childSeizure in a child after an acute ingestion of levothyroxineA thyrotoxicosis outbreak due to dietary pills in ParisMassive thyroxine intoxication: evaluation of plasma extractionCritical review and meta‐analysis of the association between overt hyperthyroidism and mortalityExcess mortality in hyperthyroidism: the influence of preexisting comorbidity and genetic confounding: a danish nationwide register‐based cohort study of twins and singletonsLow serum thyrotropin level and duration of suppression as a predictor of major osteoporotic fractures‐ the OPENTHYRO register cohortDuration of thyroid dysfunction correlates with all‐ cause mortality. The effects from a levothyroxine overdose will vary depending on how much of the medication was taken and whether it was taken