* Approximation only. Plasma protein binding displacement of warfarin was performed in the presence of statins using equilibrium dialysis method.

Any information would be helpful/I have had open heart surgery and a mitral valve replacement,stents, 2heart attacks, and coronary artery disease. Warfarin (Coumadin) is used to slow blood clotting. The anticoagulant drug warfarin and the lipid-lowering statin drugs are commonly co-administered to patients with cardiovascular diseases. Some types of statins, but not all, interfere with the breakdown of warfarin, so more warfarin stays in the bloodstream.

Fluvastatin significantly displaced plasma protein binding of warfarin and pure enantiomers; no other statin resulted in significant displacement of warfarin. When statins interact with many medications, the end result is higher than normal statin levels in the blood.

Category: Nutrition. This interaction can sometimes also reduce the effectiveness of the drug itself. The study is created by eHealthMe based on reports of 7,963 people who take Coumadin and Lipitor from the FDA, and is updated regularly.

Copyright © 2016 American Pharmacists Association®. Previous theories include kinetic alterations in cytochrome P-450-mediated drug metabolism or disturbances of drug-protein binding, leading to anticoagulant activity of warfarin; however, neither the enantioselective effects on warfarin metabolism nor the potential disruption of drug transporter function have been well investigated. Uptake transport studies of warfarin were performed using overexpressing HEK cell lines and efflux transport using human adenocarcinoma colonic cell line cells. 2020 May 20;14:1963-1970. doi: 10.2147/DDDT.S237301. We disclaim all responsibility for the professional qualifications and licensing of, and services provided by, any physician or other health providers posting on or otherwise referred to on this Site and/or any Third Party Site.

Some reports may have incomplete information.Patients can bring a copy of the report to their healthcare provider to ensure that all drug risks and benefits are fully discussed and understood.

By using this Site you agree to the following All the statins that inhibited the formation of 10-hydroxywarfarin, atorvastatin, pitavastatin, and simvastatin were highly potent compared to other statins; in contrast, only fluvastatin was found to be a potent inhibitor of formation of 7-hydroxy warfarin. ... [Oral anticoagulants and medicinal plants. Ginger can also slow blood clotting. Substrate kinetics of warfarin and pure enantiomers were performed with human liver microsomes to determine the kinetic parameters (Km and Vmax) for the formation of all 6 hydroxywarfarin metabolites, inhibition of warfarin metabolism in the presence of statins, was determined.

Drugs A-Z Pill Identifier Supplements Symptom Checker Diseases Dictionary Media 2004 Feb;24(2):285-90. doi: 10.1592/phco.24.2.285.33137.Zhu YT, Teng Z, Zhang YF, Li W, Guo LX, Liu YP, Qu XJ, Wang QR, Mao SY, Chen XY, Zhong DF.Drug Des Devel Ther. Unable to load your delegates due to an error


The Content on this Site is presented in a summary fashion, and is intended to be used for educational and entertainment purposes only. Lipitor and niacin belong to different drug classes. Clipboard, Search History, and several other advanced features are temporarily unavailable. Prilosec (omeprazole) may increase the amount of some statins present in the blood and may also increase the side effects of statins. The anticoagulant drug warfarin and the lipid-lowering statin drugs are commonly co-administered to patients with cardiovascular diseases.



After about 8 years on coumadin (due to idiopathic stroke and lung embolism), I started lipitor and recently developed mild eczema.

We offer this Site AS IS and without any warranties.

Food-Drug Interactions: Coumadin and Warfarin Diet Interactions HFFY#322.

COVID-19 is an emerging, rapidly evolving situation. An emerging interaction]. This site needs JavaScript to work properly. The anticoagulant drug warfarin and the lipid-lowering statin drugs are commonly co-administered to patients with cardiovascular diseases.
The study is created by eHealthMe based on reports of 157 people who take Lipitor and Amiodarone hydrochloride from the FDA, and is updated regularly. 2017 Aug;56(8):825-892. doi: 10.1007/s40262-017-0506-8. A licensed physician should be consulted for diagnosis and treatment of any and all medical conditions.