While you are on GEODON, check with your doctor before starting any new prescription or over-the-counter medications, including natural/herbal remedies.Because these problems could mean you’re having a heart rhythm abnormality, contact your doctor IMMEDIATELY if you:Common side effects of GEODON include the following and should also be discussed with your doctor if they occur:If you develop any side effects that concern you, talk with your doctor. What are possible side effects of Geodon? All pregnancies have a background risk of There is risk to the mother from untreated schizophrenia or bipolar I disorder, including increased risk of relapse, hospitalization, and suicide. Objectively collected data from those trials on the Simpson-Angus Rating Scale (for EPS) and the Barnes Akathisia Scale (for akathisia) did not generally show a difference between ziprasidone and placebo.Symptoms of dystonia, prolonged abnormal contractions of muscle groups, may occur in susceptible individuals during the first few days of treatment. Copyright © 2018 by RxList Inc. RxList does not provide medical advice, diagnosis or treatment. Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. Geodon belongs to a class of medications called antipsychotics. Efficacy was evaluated by analysis of the area under the curve (AUC) of the Behavioural Activity Rating Scale (BARS) and Clinical Global Impression (CGI) severity rating. The absolute bioavailability of a 20 mg dose under fed conditions is approximately 60%.

GEODON intramuscular is indicated for acute agitation in schizophrenic patients. Based upon the pharmacodynamic and pharmacokinetic profile of ziprasidone, possible interactions could be anticipated:Approximately two-thirds of ziprasidone is metabolized via a combination of chemical reduction by glutathione and enzymatic reduction by aldehyde oxidase. Dosage adjustments, if indicated, should generally occur at intervals of not less than 2 days, as steady-state is achieved within 1 to 3 days. In the second phase of the trial, ECGs were obtained at the time of maximum plasma concentration while the drug was co-administered with an inhibitor of the CYP4503A4 metabolism of the drug.In the first phase of the study, the mean change in QTc from baseline was calculated for each drug, using a sample-based correction that removes the effect of heart rate on the QT interval. Consult your healthcare professional (e.g., … Visit the MedicineNet does not provide medical advice, diagnosis or treatment. Chemically, ziprasidone hydrochloride monohydrate is 5-[2-[4-(1,2- benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2H-indol-2-one, monohydrochloride, monohydrate. Additionally, population pharmacokinetic evaluation of patients in controlled trials has revealed no evidence of clinically significant age or gender-related differences in the pharmacokinetics of ziprasidone. In the first phase of the trial, ECGs were obtained at the time of maximum plasma concentration when the drug was administered alone. The empirical formula is CGEODON Capsules are supplied for oral administration in 20 mg (blue/white), 40 mg (blue/blue), 60 mg (white/white), and 80 mg (blue/white) capsules. The BPRS psychosis cluster (conceptual disorganization, hallucinatory behavior, suspiciousness, and unusual thought content) is considered a particularly useful subset for assessing actively psychotic schizophrenic patients. In addition, patients were required to have a score of 3 or more on at least 3 of the following items of the PANSS: anxiety, tension, hostility and excitement. However, the syndrome can develop, although much less commonly, after relatively brief treatment periods at low doses.There is no known treatment for established cases of tardive dyskinesia, although the syndrome may remit, partially or completely, if antipsychotic treatment is withdrawn. To administer a 20 mg dose, draw up 1.0 mL of the reconstituted solution. An additive effect of ziprasidone and other drugs that prolong the QT interval cannot be excluded. A reaction was considered treatment emergent if it occurred for the first time or worsened while receiving therapy following baseline evaluation.The following findings are based on the short-term placebo-controlled premarketing trials for schizophrenia (a pool of two 6-week, and two 4-week fixed-dose trials) and bipolar mania (a pool of two 3-week flexible-dose trials) in which ziprasidone was administered in doses ranging from 10 to 200 mg/day.The following adverse reactions were the most commonly observed adverse reactions associated with the use of ziprasidone (incidence of 5% or greater) and not observed at an equivalent incidence among placebo-treated patients (ziprasidone incidence at least twice that for placebo): Schizophrenia trials (see Table 11)Approximately 4.1% (29/702) of ziprasidone-treated patients in short-term, placebo-controlled studies discontinued treatment due to an adverse reaction, compared with about 2.2% (6/273) on placebo. When deciding among the alternative treatments available for the condition needing treatment, the prescriber should consider the finding of ziprasidone’s greater capacity to prolong the QT/QTc interval compared to several other antipsychotic drugs [see GEODON Capsules should be administered at an initial daily dose of 20 mg twice daily with food. The risks of using ziprasidone in combination with other drugs have been evaluated as described below. GEODON Capsules contain ziprasidone hydrochloride monohydrate, lactose, pregelatinized starch, and magnesium stearate.GEODON for Injection contains a lyophilized form of ziprasidone mesylate trihydrate.