The time to onset of this form of steroid-induced liver injury can be several weeks or longer. Prophylactic antacid therapy may be indicated.In other indications initial dosage will vary from 10 to 40 mg of methylprednisolone depending on the clinical problem being treated. Do not use intra-articularly, intrabursally or for intratendinous administration for local effect in the presence of acute local infection.A study has failed to establish the efficacy of methylprednisolone sodium succinate in the treatment of sepsis syndrome and septic shock. Corticosteroids may also mask some signs of current infection. Clinical improvement or recovery after stopping corticosteroids may require weeks to years.Psychic derangements may appear when corticosteroids are used, ranging from euphoria, insomnia, mood swings, personality changes, and severe depression, to frank psychotic manifestations. Also, existing emotional instability or psychotic tendencies may be aggravated by corticosteroids.Intraocular pressure may become elevated in some individuals. • Keep this leaflet. The "gasping syndrome" (characterized by central nervous system depression, metabolic acidosis, gasping respirations, and high levels of benzyl alcohol and its metabolites found in the blood and urine) has been associated with benzyl alcohol dosages >99 mg/kg/day in neonates and low-birth-weight neonates. [See USP Controlled Room Temperature. When given parenterally and in equimolar quantities, the two compounds are equivalent in biologic activity. The desired dose may be administered intravenously over a period of several minutes.To prepare solutions for intravenous infusion, first prepare the solution for injection as directed. Following the initial emergency period, consideration should be given to employing a longer acting injectable preparation or an oral preparation.There are reports of cardiac arrhythmias and/or cardiac arrest following the rapid administration of large intravenous doses of SOLU-MEDROL (In general, high dose corticosteroid therapy should be continued only until the patient's condition has stabilized; usually not beyond 48 to 72 hours.In other indications, initial dosage will vary from 10 to 40 mg of methylprednisolone depending on the specific disease entity being treated. The larger doses may be required for short-term management of severe, acute conditions. It is very soluble in water and in alcohol; it is insoluble in chloroform and is very slightly soluble in acetone.The chemical name for methylprednisolone sodium succinate is pregna-1,4-diene-3,20-dione,21-(3-carboxy-1-oxopropoxy)-11,17-dihydroxy-6-methyl-monosodium salt, (6α, 11β), and the molecular weight is 496.53. 0009-0039-28,

SOLU-MEDROL Sterile Powder is an anti-inflammatory glucocorticoid, which contains methylprednisolone sodium succinate as the active ingredient. If exposed to chicken pox, prophylaxis with varicella zoster immune globulin (VZIG) may be indicated. 5.Invert vial. This preparation is also rapidly absorbed when administered intramuscularly and is excreted in a pattern similar to that observed after intravenous injection.When oral therapy is not feasible, and the strength, dosage form, and route of administration of the drug reasonably lend the preparation to the treatment of the condition, the Control of severe or incapacitating allergic conditions intractable to adequate trials of conventional treatment in asthma, atopic dermatitis, contact dermatitis, drug hypersensitivity reactions, perennial or seasonal allergic rhinitis, serum sickness, transfusion reactions.Bullous dermatitis herpetiformis, exfoliative erythroderma, mycosis fungoides, pemphigus, severe erythema multiforme (Stevens-Johnson syndrome).Primary or secondary adrenocortical insufficiency (hydrocortisone or cortisone is the drug of choice; synthetic analogs may be used in conjunction with mineralocorticoids where applicable; in infancy, mineralocorticoid supplementation is of particular importance), congenital adrenal hyperplasia, hypercalcemia associated with cancer, nonsuppurative thyroiditis. The use of oral corticosteroids is not recommended in the treatment of optic neuritis and may lead to an increase in the risk of new episodes. Solu-Medrol® Methylprednisolone Sodium Succinate, Preservative Free 125 mg / 2 mL Injection Single Dose Act-O-Vial* 2 mL Pfizer 00009004722 [See USP Controlled Room Temperature. 0009-0796-01, • If you have any … Corticosteroids should be used cautiously in patients with ocular herpes simplex because of corneal perforation.

For chronic overdosage in the face of severe disease requiring continuous steroid therapy, the dosage of the corticosteroid may be reduced only temporarily, or alternate day treatment may be introduced.Use only the accompanying diluent or Bacteriostatic Water For Injection with Benzyl Alcohol when reconstituting SOLU-MEDROL (see Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.This preparation may be administered by intravenous injection, by intravenous infusion, or by intramuscular injection, the preferred method for initial emergency use being intravenous injection. Copy the URL below and paste it into your RSS Reader application. The structural formula is represented below:Methylprednisolone sodium succinate is soluble in water; it may be administered in a small volume of diluent and is well suited for intravenous use in situations where high blood levels of methylprednisolone are required rapidly.SOLU-MEDROL is available in preservative and preservative-free formulations:When necessary, the pH of each formula was adjusted with sodium hydroxide so that the pH of the reconstituted solution is within the USP specified range of 7 to 8 and the tonicities are, for the 40 mg per mL solution, 0.50 osmolar; for the 125 mg per 2 mL solution, 0.40 osmolar; for the 1 gram per 8 mL solution, 0.44 osmolar; for the 2 gram per 30.6 mL solutions, 0.42 osmolar.