Therefore, serum lithium levels should be monitored carefully if lithium salts are to be co-administered with angiotensin II receptor antagonists. Dosage adjustment of antidiabetic agents, including insulin, may be required (see section 4.5). This site uses cookies. Increase in dosage of probenecid or sulfinpyrazone may be necessary. These effects are usually reversible.Clinical trial data have shown that dual blockade of the renin-angiotensin-aldosterone system (RAAS) through the combined use of ACE-inhibitors, angiotensin II receptor blockers or aliskiren is associated with a higher frequency of adverse events such as hypotension, hyperkalaemia, and decreased renal function (including acute renal failure) compared to the use of a single RAAS-acting agent (see sections 4.3, 4.4, and 5.1).Other substances inducing hypotension like tricyclic antidepressants, antipsychotics, baclofene, amifostine: Concomitant use with these drugs that lower blood pressure, as main or side-effect, may increase the risk of hypotension. COZAAR® is indicated for the treatment of hypertension in adults and pediatric patients 6 years of age and older, to lower blood pressure. Foetal toxicity in rats, as evidenced by a slight increase in supernumerary ribs in the FCozaar Comp 50 mg/12.5 mg, Cozaar Comp 100 mg/12.5 mg and Cozaar Comp 100 mg/25 mg:Cozaar Comp 50 mg/12.5 mg contains 4.24 mg (0.108 mEq) of potassium. Store in the original package in order to protect from light and moisture.Do not store above 25°C. … The systemic bioavailability of losartan tablets is approximately 33%. Thiazides should be discontinued before carrying out tests for parathyroid function.Increases in cholesterol and triglyceride levels may be associated with thiazide diuretic therapy.Thiazide therapy may precipitate hyperuricemia and/or gout in certain patients. Cozaar Comp 100/12.5 (losartan 100 mg/ HCTZ 12.5 mg) is available for those patients titrated to 100 mg of Cozaar who require additional blood pressure control. When given concurrently, the following drugs may interact with thiazide diuretics:The treatment with a thiazide may influence the glucose tolerance. Studies in rats indicate that losartan crosses the blood-brain barrier poorly, if at all.Hydrochlorothiazide crosses the placental but not the blood-brain barrier and is excreted in breast milk.About 14% of an intravenously- or orally-administered dose of losartan is converted to its active metabolite. Concomitant use of angiotensin II antagonists or diuretics and NSAIDs may lead to an increased risk of worsening of renal function, including possible acute renal failure, and an increase in serum potassium, especially in patients with poor pre-existing renal function. Kohlpharma GmbHIn diesem Beipackzettel finden Sie verständliche Informationen zu Ihrem Arzneimittel – unter anderem zu Wirkung, Anwendung und Nebenwirkungen. Losartan should be used with caution in patients with bilateral renal artery stenosis or stenosis of the artery to a solitary kidney. Therapy with Cozaar Comp should be discontinued and the patient observed closely.

If digitalis has also been administered, hypokalemia may accentuate cardiac arrhythmias.The degree to which hydrochlorothiazide is removed by haemodialysis has not been established.Pharmacotherapeutic group: Angiotensin II antagonists and diuretics, ATC code: C09DA01The components of Cozaar Comp have been shown to have an additive effect on blood pressure reduction, reducing blood pressure to a greater degree than either component alone. • Some antipsychotics (e.g. The maximum dose is one tablet of Cozaar Comp 100 mg/25 mg once daily.

4.5 Interaction with other medicinal products and other forms of interaction6.6 Special precautions for disposal and other handling9. Unless continued AIIRA therapy is considered essential, patients planning pregnancy should be changed to alternative anti-hypertensive treatments which have an established safety profile for use in pregnancy. Cardiovascular death and stroke were both numerically more frequent in the aliskiren group than in the placebo group and adverse events and serious adverse events of interest (hyperkalaemia, hypotension and renal dysfunction) were more frequently reported in the aliskiren group than in the placebo group.Hydrochlorothiazide is a thiazide diuretic.

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