Pioglitazone is associated with edema (peripheral, generalized, and pitting edema and Postmarketing reports of congestive heart failure have been received in patients treated with pioglitazone.

Some patients improved with drug discontinuation.Postmarketing reports of fatal and nonfatal hepatic failure have been received in patients treated with this drug; these reports have been insufficient to establish causality. Overall, this drug may be associated with an increase in the risk of urinary bladder tumors, however there is insufficient data to determine whether this drug is a tumor promoter for urinary bladder tumors.1.

If you have any questions, ask your doctor or pharmacist. Actos (pioglitazone)" Takeda Pharmaceuticals America, Lincolnshire, IL. No statistically significant difference between pioglitazone and placebo/standard care were observed for time to the first occurrence of their first event (all-cause mortality, nonfatal myocardial infarction (MI) including silent MI, stroke, acute coronary syndrome, cardiac intervention including coronary artery bypass grafting or percutaneous intervention, major leg amputation above the ankle, and bypass surgery or revascularization in the leg). The chance may be raised when pioglitazone is used with other drugs for diabetes. Other side effects include: cardiac failure, exacerbation of congestive heart failure, bone fracture, headache, and pharyngitis. Reports have been received from patients both with and without a history of a known history of heart disease and both with and without concomitant The most commonly reported side effects were hypoglycemia, increased weight, edema, and Visual disturbances have been reported early in treatment and may be related to changes in blood glucose due to temporary alteration in the turgidity and refractive index of the lens. Signs may be dizziness , headache, feeling sleepy or weak, shaking, fast heartbeat, confusion, hunger, or sweating.

Call your doctor for medical advice about side effects. ([2016, Dec 12]):Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.Some side effects may not be reported. O 03. All rights reserved. More common side effects. You may report side effects to the FDA at 1-800-FDA-1088.Portions of this document last updated: May 01, 2020Copyright © 2020 IBM Watson Health. Side effects of pioglitazone include: swelling (edema), when used in combination with sulfonylurea or insulin low blood sugar (hypoglycemia) A total of 514 patients receiving pioglitazone experienced at least 1 event compared with 572 patients receiving placebo/standard care. stomach pain. These side effects may go away during treatment as … Pioglitazone hydrochloride may cause or worsen congestive Along with its needed effects, pioglitazone may cause some unwanted effects. US Food and Drug Administration "Updated FDA review concludes that use of type 2 diabetes medicine pioglitazone may be linked to an increased risk of bladder cancer. Our general interest e-newsletter keeps you up to date on a wide variety of health topics.Along with its needed effects, a medicine may cause some unwanted effects. unexplained, rapid weight gain. Low blood sugar can happen. Incidence not known. A 10-year prospective cohort study in diabetic patients performed by the manufacturer (n=158,918 never users; n=34,181 ever users) identified 1075 newly diagnosed cases of bladder cancer in never users and 186 cases in ever users. yellow eyes or skin.

O 04. Most patients had peripheral edema at time of diagnosis.

Take this medication by mouth as directed by your doctor, usually once daily with the evening meal to decrease stomach upset. © 1998-2020 Mayo Foundation for Medical Education and Research (MFMER). Call your doctor right away if you have any of these signs. Compared to the interim 5-year results, the 10-year results found weaker associations that were not statistically significant. Although not all of these side effects may occur, if they do occur they may need medical attention.Some side effects of pioglitazone may occur that usually Check with your health care professional if any of the following side effects In the PROactive trial, a study in 5238 patients with The primary objective of the 3-year PROactive trial was to examine the effect of pioglitazone on mortality and macrovascular morbidity in high-risk patients. See below for a comprehensive list of adverse effects. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below.

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Available from: URL: http://www.fda.gov/downloads/Drugs/DrugSafety/UCM532691.pdf."

nausea or vomiting.

However, there are studies that have shown a statistically significant association between exposure to this drug and bladder cancer and an association between cumulative dose or cumulative duration of exposure and bladder cancer.

You may report them to the The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. These side effects may go away during treatment as your body adjusts to the medicine.

2. The majority of fractures were nonvertebral including lower limb and distal upper limb. The fully adjusted hazard ratio (HR) showed pioglitazone use was not associated with an increased risk (HR 1.06 (95% confidence interval 0.89 to 1.26).