In dogs, metronomic chemotherapy has also been shown to slow down recurrence of soft tissue sarcomas. 2014 Jul;55(7):369-74. doi: 10.1111/jsap.12228. Spugnini, E. P., Buglioni, S., Carocci, F., Francesco, M., Vincenzi, B.Spugnini, EP, Buglioni, S, Carocci, F, Francesco, M, Vincenzi, BSpugnini EP, Buglioni S, Carocci F, Francesco M, Vincenzi BSpugnini, Enrico P. ; Buglioni, Sabrina ; Carocci, Francesca ; Francesco, Menicagli ; Vincenzi, Bruno title = "High dose lansoprazole combined with metronomic chemotherapy: a phase I/II study in companion animals with spontaneously occurring tumors", abstract = "BACKGROUND: The treatment of human cancer has been seriously hampered for decades by resistance to chemotherapeutic drugs. Median time to terminal event was 34 weeks for the experimental group versus 2 weeks in the controls (p= 0.042).CONCLUSIONS: Patient alkalization has shown to be well tolerated and to increase tumor response to metronomic chemotherapy as well the quality of life in pets with advanced cancer. Wiley A very efficient mechanism of tumor resistance to drugs is the proton pumps-mediated acidification of tumor microenvironment. Median time to terminal event was 34 weeks for the experimental group versus 2 weeks in the controls (p= 0.042).CONCLUSIONS: Patient alkalization has shown to be well tolerated and to increase tumor response to metronomic chemotherapy as well the quality of life in pets with advanced cancer. 2019 Jun 27;15(1):217. doi: 10.1186/s12917-019-1956-z.Boland L, Setyo L, Sangster C, Brunel L, Foo T, Bennett P.JFMS Open Rep. 2019 May 28;5(1):2055116919849979. doi: 10.1177/2055116919849979. On the other hand, only one patient in the control group experienced a complete response (10%) and three other experienced short lived responses. Burton JH, Mitchell L, Thamm DH, Dow SW, Biller BJ.J Vet Intern Med. Metronomic chemotherapy has shown efficacy in adjuvant fashion as well as in the treatment of pets with advanced disease. Severe Interactions. Further studies are warranted to assess the efficacy of this strategy in patients with advanced cancers in companion animals as well as in humans.T1 - High dose lansoprazole combined with metronomic chemotherapyT2 - a phase I/II study in companion animals with spontaneously occurring tumorsN2 - BACKGROUND: The treatment of human cancer has been seriously hampered for decades by resistance to chemotherapeutic drugs.

This benefit is sometimes used to treat dogs with dilated cardiomyopathy (heart muscle disease). In this study pet with spontaneously occurring cancer have been recruited to be treated by a combination of metronomic chemotherapy and high dose PPIs and their responses have been matched to those of a historical control of ten patients treated with metronomic chemotherapy alone.METHODS: Single arm, non randomized phase II open study, with historical control group, evaluating safety and efficacy of the combination of metronomic chemotherapy and alkalization. Twelve treated dogs (40%) experienced mild toxicity (grade 1 and 2) at some point during treatment and 1 dog developed grade 4 cystitis. A very efficient mechanism of tumor resistance to drugs is the proton pumps-mediated acidification of tumor microenvironment.

View full fingerprint Moreover, we have shown in veterinary clinical settings that pre-treatment with proton-pumps inhibitors (PPI) increases tumor responsiveness to chemotherapeutics. Together they form a unique fingerprint. In terms of overall response, in the alkalized cohort, 18 out of 24 had partial or complete responses (75%), two patients had a stable disease and the remaining patients experienced no response or progressive disease. High dose lansoprazole combined with metronomic chemotherapy: a phase I/II study in companion animals with spontaneously occurring tumorsHigh dose lansoprazole combined with metronomic chemotherapy: a phase I/II study in companion animals with spontaneously occurring tumorsHigh dose lansoprazole combined with metronomic chemotherapy: a phase I/II study in companion animals with spontaneously occurring tumors Clipboard, Search History, and several other advanced features are temporarily unavailable. Their responses have been evaluated by clinical and instrumental evaluation and matched to those of the control group.RESULTS: The protocol was overall well tolerated, with only two dogs experiencing side effects due to gastric hypochlorhydria consisting with vomiting and or diarrhea. Epub 2014 May 7.London CA, Gardner HL, Mathie T, Stingle N, Portela R, Pennell ML, Clifford CA, Rosenberg MP, Vail DM, Williams LE, Cronin KL, Wilson-Robles H, Borgatti A, Henry CJ, Bailey DB, Locke J, Northrup NC, Crawford-Jakubiak M, Gill VL, Klein MK, Ruslander DM, Thamm DH, Phillips B, Post G.PLoS One. These … In this study pet with spontaneously occurring cancer have been recruited … ", author = "Spugnini, {Enrico P.} and Sabrina Buglioni and Francesca Carocci and Menicagli Francesco and Bruno Vincenzi and Maurizio Fanciulli and Stefano Fais", 2015 Apr 29;10(4):e0124889. This side effect is not a major issue in most dogs that receive a limited amount of doxorubicin in their lifetime. ... Piroxicam has antitumour effects in dogs with cancer, although side effects … In terms of overall response, in the alkalized cohort, 18 out of 24 had partial or complete responses (75%), two patients had a stable disease and the remaining patients experienced no response or progressive disease. Epub 2011 Jul 7.Bracha S, Walshaw R, Danton T, Holland S, Ruaux C, Obradovich J.J Small Anim Pract. COVID-19 is an emerging, rapidly evolving situation.