I was simply astounded by a publication appearing last week in Oncotarget on anti-cancer synergy of Doxycyline and vitamin C.(1) This is a really huge breakthrough in cancer research, in our quest for effective non-toxic cancer treatment. Recall that in an evolutionary sense, mitochondria are descendants of bacteria and remain sensitive to the antibiotics more often employed to inhibit bacterial growth.Doxycycline is already used to treat infections in cancer patients and there have been case reports of unexpected remissions, particularly in lymphoma.In April 2017 Zhang et al delineated doxycycline’s action inhibiting the transitional steps of stem cell phenotypes into breast cancer.In June 2017 this research took a turn that many of us will find fascinating: Lisanti’s group reported that the effect of doxycycline is optimized when combined with vitamin C and berberine in vitro.
Applies to the following strengths: hyclate 100 mg; hyclate 50 mg; 100 mg; 25 mg/5 mL; 50 mg/5 mL; monohydrate 150 mg; 20 mg; monohydrate 50 mg; monohydrate 75 mg; monohydrate 100 mg; hyclate 75 mg; 40 mg; hyclate 150 mg; hyclate 200 mg; 200 mg; monohydrate 150 mg tablet with cleanser; monohydrate 150 mg capsule with cleanser; 100 mg with vitamins and minerals; hyclate 100 mg capsule with cleanser; hyclate 50 mg capsule with cleanser; 120 mg; hyclate 50 mg capsule with cleanser and ocular lubricantUS CDC Recommendations: 100 mg orally twice a day for 7 daysInitial dose: 200 mg IV on the first day, given in 1 or 2 infusionsUS CDC Recommendations: 100 mg orally twice a day for 7 daysIDSA Recommendations: 100 to 200 mg orally twice a dayUS CDC Recommendations: 100 mg orally every 12 hoursUS CDC Recommendations: 100 mg orally or IV every 12 hoursIDSA Recommendations: 100 mg orally twice a day or 200 mg orally once a dayUS CDC Recommendations: 100 mg orally twice a day for 7 daysUS CDC Recommendations: 100 mg orally or IV twice a day for 7 to 14 daysConsult WARNINGS section for additional precautions.Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. This medicine comes with patient instructions. This means we don't know how successful this strategy could be – and the Mail's claim there would be no side effects is unsupported. Clinical trials look at new ways to prevent, detect, or treat disease. 72% of the control patients have died compared to 16% of the doxycycline treated group (at 2.3 months). Of note, an April 2019 publication suggested that adding azithromycin might further enhance the effectiveness of a doxycycline and vitamin C combination.These publications suggest some obvious implications.
In my practice, I often recommend supplementing each 50 mg dose with a 325 mg tablet of acetaminophen (Tylenol). This happens when certain cells, such as muscles, continue to work hard without oxygen, producing a build-up of lactic acid, and doesn't require oxygen or mitochondria.This study looked at whether two natural products and six different drugs already approved for use in humans could kill cancer cells reliant on making energy using glycolysis – or in other words, kill the cancer cells that had resisted the initial treatment with doxycycline.The natural products were vitamin C and berberine, a type of salt found in many plants. There is no published evidence that doing so will lower risk of cancer or its recurrence, but could it hurt?Such prophylaxis might be particularly useful in patients previously treated for cancers whose recurrences we suspect are driven by cancer stem cells. The news comes from the results of a study that found a new two-pronged approach using the antibiotic doxycycline followed by Doxycycline killed many cancer cells, but others became resistant. The researchers concluded that doxycycline can kill some cancer cells and make others reliant on one energy pathway: glycolysis.