Side effects, usually minor, are more likely during a prolonged course of treatment. Duration of therapy: At least 3 months and until clinical parameters and laboratory tests indicate the active fungal infection has subsided. Drugs such as HMG-CoA reductase inhibitors, benzodiazipines, quinidine and warfarin may need dose adjustment or discontinuation for the duration of itraconazole administration. The recommended dose of XELODA is 1250 mg/m 2 administered orally twice daily (morning and evening; equivalent to 2500 mg/m 2 total daily dose) for 2 weeks followed by a 1-week rest period given as 3-week cycles (see Table 1). XELODA tablets should be swallowed whole with water within 30 minutes after a meal. Tell your doctor right away if you have any serious side effects, including: numbness/tingling of arms/legs, hearing loss, mental/mood changes (such as depression). Available for Android and iOS devices. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Children—Use and dose must be determined by your doctor. Select one or more newsletters to continue. Insufficient data are available to provide a dosage recommendation.Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Maintenance dose: 200 mg orally once or twice a day. These side effects may go away during treatment as your body adjusts to the medicine. Adults—200 milligrams (mg) once a day for 12 weeks in a row. XELODA is a cytotoxic drug. Applies to the following strengths: 100 mg; 200 mg; 10 mg/mL; 250 mg; 65 mgLoading dose: 200 mg orally 3 times a day for the first 3 days of therapyLoading dose: 200 mg orally 3 times a day for the first 3 days of therapyLoading dose: 200 mg orally 3 times a day for the first 3 days of therapyLoading dose: 200 mg orally 3 times a day for the first 3 days of therapyOropharyngeal candidiasis: 200 mg orally once a dayTreatment pulse: 200 mg orally twice a day for 1 weekIDSA Recommendations: 200 mg orally 2 or 3 times a dayVulvovaginal candidiasis: 200 mg orally twice a day for 1 daySome experts recommend adjusting dose based on drug serum levels and/or drug interactions.Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Select one or more newsletters to continue. We comply with the HONcode standard for trustworthy health information - In patients with moderate renal impairment (baseline creatinine clearance = 30 to 50 mL/min), a dose reduction to 75% of the XELODA starting dose when used as monotherapy or in combination with docetaxel (from 1250 mg/mCreatinine clearance for females = 0.85 × male valuePhysicians should exercise caution in monitoring the effects of XELODA in the elderly. Children—Use and dose must be determined by your doctor. Available for Android and iOS devices. Adults—100 milligrams (mg) or 10 milliliters (mL) once a day for a minimum of 3 weeks. Patients were treated with oral itraconazole, initially 200 mg/day for a week, followed by a maintenance therapy of a single dose of 200 mg every 2 weeks. Side effects of itraconazole Itraconazole appears to be a relatively safe drug. The Food and Drug Administration has labeled itraconazole as a pregnancy category C, meaning animal studies have shown adverse effects on fetus development but there is inadequate data on human … Monotherapy (Metastatic Colorectal Cancer, Adjuvant Colorectal Cancer, Metastatic Breast Cancer)Table 1 XELODA Dose Calculation According to Body Surface AreaIn Combination With Docetaxel (Metastatic Breast Cancer)Monotherapy (Metastatic Colorectal Cancer, Adjuvant Colorectal Cancer, Metastatic Breast Cancer)In Combination With Docetaxel (Metastatic Breast Cancer)Table 3 Docetaxel Dose Reduction Schedule in Combination with XELODAWe comply with the HONcode standard for trustworthy health information - Itraconazole, (Sporanox®, Janssen Pharmaceuticals) a triazole, is highly keratinophilic and lipophilic, and tissue levels of the triazole are several times higher than peak plasma levels.5 As a result, itraconazole tends to reach high concentrations in the epidermis and may persist in the skin for 3-4 weeks depending upon the site of infection, thus creating a therapeutic reservoir.6 Furthermore, itraconazole does not redistribute into the systemic circulation.6 Itraconazole is ac… Patients should be carefully monitored for toxicity and doses of XELODA should be modified as necessary to accommodate individual patient tolerance to treatment The dose of phenytoin and the dose of coumarin-derivative anticoagulants may need to be reduced when either drug is administered concomitantly with XELODA XELODA dose modification scheme as described below (see Dose modifications of XELODA for toxicity should be made according to The dose reduction schedule for docetaxel when used in combination with XELODA for the treatment of metastatic breast cancer is shown in No adjustment to the starting dose of XELODA is recommended in patients with mild renal impairment (creatinine clearance = 51 to 80 mL/min [Cockroft and Gault, as shown below]). The dose of itraconazole in children is usually 5 mg per kg body weight per day to maximum 200 mg per day, but is reserved for exceptional circumstances.

Compared to placebo there was a significant improvement in SCORAD of the head and neck area in favour of the 200 mg itraconazole group after 14 days. Itraconazole … Follow applicable special handling and disposal procedures.Adjuvant treatment in patients with Dukes' C colon cancer is recommended for a total of 6 months [ie, XELODA 1250 mg/mIn combination with docetaxel, the recommended dose of XELODA is 1250 mg/mXELODA dosage may need to be individualized to optimize patient management. Loading dose: 200 mg orally 3 times a day for the first 3 days of therapy. One week of treatment with 200 or 400 mg itraconazole as a single treatment has a significant effect on the head and neck area.