Topical analgesic include but are not limited to morphine and its derivatives, cocaine and its derivative, capsaicin (the active ingredients of hot pepers), specific inhibitors of capsaicin responding receptors (such as TrpV1).

The Ocular Surface/April 2007, Vol. It also shows minimal toxicity in the human bone marrow progenitor cell assay.Tenofovir plus (lamivudine or emtricitabine) (for Tanner stage 4 or postpubertal adolescents only)Lamivudine and abacavir do not share many of the serious mitochondrial toxicities associated with other NRTIs. The layers can be used to deliver an active agent to a mucous membrane. By helping to stabilize the tear film, mucins are essential for maintaining ocular surface health. Cystic Fibrosis: A defect in the CFTR gene causes cystic fibrosis (CF). In fact, many infants born before 28 weeks of pregnancy develop RDS. Infant respiratory distress syndrome (RDS; also known as hyaline membrane disease): RDS is a common lung disorder in premature infants. Vis.

Suitable organic molecules include but are not limited to amino acids, peptides, polypeptides, proteins, lipids, carbohydrates, glycoaminoglycans, nucleic acids and combinations thereof. We 100% guarantee it! Activated dendrimers are an example of multifunctional crosslinkers.The term “subject” refers to any animal (e.g., a mammal), including, but not limited to, humans, non-human primates, rodents, dogs, cats, and the like, which is to be the recipient of a particular treatment. In some embodiments the subject is suffering from a dry nose.

In other embodiments a sheet of a water soluble polymer is used.In some embodiments, the polymers are applied to a target mucous membrane by a spray, such as via a pump, nebulizing or aerosol device. Spegra (Долутеглавир / Тенофовир алафенамид / Эмтрицитабин) - Спегра (Dolutegravir/ Taf / Emtricitabine) – это лекарство для лечения людей, которые столкнулись с ВИЧ-1 инфекцией. Davidovich-Pinhas et al. Like tears it is complex in its composition and has many additional roles associated with the digestive process. When KO mice were compared to WT mice, the mean tear break up time (TBUT) values were significantly lower and corneal fluorescein staining scores were significantly higher.
If more than one agent is utilized to modify the mucous membrane, including the cellular and/or thin film elements of the mucous membrane, the agents may be added at the same time or sequentially.

In further embodiments, nano- or micro-particles are arranged on the stamp for delivery to the mucous membrane. In other embodiments, the agents or agents may be applied in patterns or gradients on the target mucous membrane.It will be further understood that target mucous membranes may be modified by a combination of agents that physically interact with components of the mucous membrane and optionally agent(s) that physically react with the mucous membrane following an initial modification. Suitable targets for modification by the compositions and methods of the present invention include, but are not limited to, lipid, protein, glycoaminoglycan, and/or carbohydrate components of cell surfaces and/or the tear film or other intimately associated thin films associated with mucous membranes (e.g., saliva, thin films associated with the alimentary tract, cervico-vaginal secretions and thin films associated with the female reproductive tract, respiratory thin films). Dry mouth can be a consequence of certain health conditions—or their treatments—including the autoimmune disease Sjogren's syndrome, diabetes, Parkinson's disease, HIV/AIDS, anxiety disorders and depression. These results document a significant difference in the quality, but not the quantity, of tear fluid in the KO mice compared to WT mice. Desensitization to topical TRPV1 agonists (e.g. These medicines can speed up surfactant production and lung development in a fetus. For example, in some embodiments, a linker comprising an activated acid (e.g., NHS (N-hydroxysuccinimydl)) is used to react with amine groups presented by components of the mucous membrane and a second linker comprising a malemide is used to react with sulfhydryl groups presented by components of the mucous membrane. An exemplary second agent would be an amphiphilic substance or an ionic substance. In other embodiments, the agents are applied by a drop dispensers such as the tip of a pin or in an open capillary and, touch the pin or capillary to the surface of the substrate. In some embodiments, the first agent physically interacts or reacts with the cellular surface constituents of the mucous membrane including but not limited to mucins associated with cellular constituents, soluble mucins in the thin fluid film associated with the cellular elements, other membrane associated proteins, lipids, constituents of the glycocalyx and associated constituents, and carbohydrates.
In rare cases, it may be a symptom of collagen vascular diseases, including rheumatoid arthritis, Wegener's granulomatosis, and systemic lupus erythematosus.