to be nonmutagenic in the Ames assay.
performance were observed in rats given oral dosages as high as 70 mg/kg/day

Active Ingredients Strength Dosage Form/Route Marketing Status; SULFATRIM: SULFAMETHOXAZOLE; TRIMETHOPRIM: 200MG/5ML;40MG/5ML: SUSPENSION;ORAL: Discontinued: SULFATRIM PEDIATRIC: SULFAMETHOXAZOLE; TRIMETHOPRIM: 200MG/5ML;40MG/5ML: SUSPENSION;ORAL: Prescription: User Comments: For Bronchitis “So, … In an established infection, they will not eradicate the streptococcus and, therefore, will not prevent sequelae such as rheumatic fever.CDAD must be considered in all patients who present with diarrhea following antibiotic use. Sulfonamides can also displace methotrexate from plasma
Store at controlled room temperature 15°-30°C (59°-86°F).

S547-S555.Patients should be counseled that antibacterial drugs Sulfamethoxazole and trimethoprim is also contraindicated in pregnant patients and nursing mothers, because sulfonamides pass the placenta and are excreted in the milk and may cause kernicterus. The total daily dose

Patients who are "slow acetylators" may be more prone to idiosyncratic reactions to sulfonamides.Patients should be counseled that antibacterial drugs including sulfamethoxazole and trimethoprim oral suspension should only be used to treat bacterial infections.

PRODUCT MONOGRAPH APO-SULFATRIM … PursellBecause sulfamethoxazole and trimethoprim may interfere In glucose-6- phosphate dehydrogenase deficient individuals, hemolysis may occur. Patients with renal dysfunction, liver disease, malnutrition or those receiving high doses of sulfamethoxazole and trimethoprim are particularly at risk.Hematological changes indicative of folic acid deficiency may occur in elderly patients or in patients with preexisting folic acid deficiency or kidney failure.

should not exceed 1600 mg sulfamethoxazole and 320 mg trimethoprim.For the treatment of travelers' diarrhea, the usual adult susceptible strains of enterotoxigenic The usual adult dosage in the treatment of urinary tract Select one or more newsletters to continue. to feel better early in the course of therapy, the medication should be taken The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.Using this medicine with any of the following medicines is not recommended. Keep from freezing.Do not keep outdated medicine or medicine no longer needed.Ask your healthcare professional how you should dispose of any medicine you do not use.Using this medicine while you are pregnant can harm your unborn baby. marrow depression.General principles of treatment include the institution

If you notice any other effects, check with your healthcare professional.Call your doctor for medical advice about side effects. The mean serum half-lives of No interference occurs, however, if methotrexate is measured by a radioimmunoassay (RIA).The presence of sulfamethoxazole and trimethoprim may also interfere with the Jaffé alkaline picrate reaction assay for creatinine, resulting in overestimations of about 10% in the range of normal values.Long-term studies in animals to evaluate carcinogenic potential have not been conducted with sulfamethoxazole and trimethoprim.Bacterial mutagenic studies have not been performed with sulfamethoxazole and trimethoprim in combination. In these cases, your doctor may want to change the dose, or other precautions may be necessary.

is measured by a The presence of sulfamethoxazole and trimethoprim may Sulfamethoxazole and Trimethoprim Oral Suspension USP (Pediatric), containing 200 mg sulfamethoxazole and 40 mg trimethoprim per teaspoonful (5 mL), is a cherry flavored suspension available in 100 mL and pint (473 mL) bottles. These effects are reversible by folinic acid therapy.Trimethoprim has been noted to impair phenylalanine metabolism, but this is of no significance in phenylketonuric patients on appropriate dietary restriction.As with all drugs containing sulfonamides, caution is advisable in patients with porphyria or thyroid dysfunction.AIDS patients may not tolerate or respond to sulfamethoxazole and trimethoprim in the same manner as non-AIDS patients.

If you think you have become pregnant while using the medicine, tell your doctor right away.Very rarely, this medicine has caused severe side effects. h�bbd```b``�"!�Kɜ&׃H�pɮf��Ӭ�$c�$�!Dک���-L��A"@��"�3|�� ` �� The recommended dose for children with urinary tract h�b```�NfIA��1�$_����]\�QƤ���pJ������"p�1Q��? Talk with your doctor if you have concerns about this.This medicine may cause diarrhea, and in some cases it can be severe. Trimethoprim blocks the production of tetrahydrofolic acid from dihydrofolic acid by binding to and reversibly inhibiting the required enzyme, dihydrofolate reductase. to treat bacterial infections. S657-S663.The amount of a single dose of sulfamethoxazole and