With increasing doses of corticosteroids, the rate of occurrence of infectious complications increases.Prolonged use of corticosteroids may produce posterior subcapsular cataracts, glaucoma with possible damage to the optic nerves, and may enhance the establishment of secondary ocular infections due to fungi or viruses.Average and large doses of hydrocortisone or cortisone can cause elevation of blood pressure, salt and water retention, and increased excretion of potassium. Your doctor may occasionally change your dose. Follow all directions on your prescription label. These include fever, chills, or body aches.People who receive the smallpox vaccine while taking this drug have a higher risk of serious side effects. This makes it easier for you to get infections and harder for you to fight infections. Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional.Written by University of Illinois-Chicago, Drug Information GroupWritten by University of Illinois-Chicago, Drug Information Group Symptoms can include:If you have an allergic reaction, call your doctor or local poison control center right away. Once control is again established alternate day therapy may be reinstituted.9) Although many of the undesirable features of corticosteroid therapy can be minimized by ADT, as in any therapeutic situation, the physician must carefully weigh the benefit-risk ratio for each patient in whom corticoid therapy is being considered.NDC: 63739-133-10 10 TABLET in a BLISTER PACK / 10 in a BOX, UNIT-DOSE IT SHOULD BE EMPHASIZED THAT DOSAGE REQUIREMENTS ARE VARIABLE AND MUST BE INDIVIDUALIZED ON THE BASIS OF THE DISEASE UNDER TREATMENT AND THE RESPONSE OF THE PATIENT. Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional.© 2004-2020 Healthline Media UK Ltd, Brighton, UK, a Red Ventures Company. Thank you! The structural formula is represented below:Each methylprednisolone tablet, USP for oral administration contains 4 mg of methylprednisolone, USP. The dosage and length of treatment are based on your medical condition and response to treatment. ... 2nd Day: 1 tablet (4 mg) before breakfast. These include endocrine diseases, severe allergies, ulcerative colitis, and multiple sclerosis. The following information includes only the average doses of this medicine. In addition, they modify the body's immune responses to diverse stimuli.Methylprednisolone tablets are indicated in the following conditions:Primary or secondary adrenocortical insufficiency (hydrocortisone or cortisone is the first choice; synthetic analogs may be used in conjunction with mineralocorticoids where applicable; in infancy mineralocorticoid supplementation is of particular importance).As adjunctive therapy for short-term administration (to tide the patient over an acute episode or exacerbation) in:Rheumatoid arthritis, including juvenile rheumatoid arthritis (selected cases may require low-dose maintenance therapy)During an exacerbation or as maintenance therapy in selected cases of:Control of severe or incapacitating allergic conditions intractable to adequate trials of conventional treatment:Severe acute and chronic allergic and inflammatory processes involving the eye and its adnexa such as:Fulminating or disseminated pulmonary tuberculosis when used concurrently with appropriate antituberculous chemotherapyTo induce a diuresis or remission of proteinuria in the nephrotic syndrome, without uremia, of the idiopathic type or that due to lupus erythematosus.To tide the patient over a critical period of the disease in: Trichinosis with neurologic or myocardial involvement.Systemic fungal infections and known hypersensitivity to components.In patients on corticosteroid therapy subjected to unusual stress, increased dosage of rapidly acting corticosteroids before, during, and after the stressful situation is indicated.Corticosteroids may mask some signs of infection, and new infections may appear during their use. It is used to treat a number of different conditions, such as inflammation (swelling), severe allergies, adrenal problems, arthritis, asthma, blood or bone marrow problems, eye or vision problems, lupus, skin conditions, kidney problems, ulcerative colitis, and flare-ups of multiple sclerosis.