As a class, β-lactams inhibit bacterial cell wall synthesis by binding to one or more of the penicillin-binding proteins (PBPs).

Sterile Cefotaxime sodium is a semisynthetic, broad spectrum cephalosporin antibiotic for parenteral administration.

The MICs should be determined using a standardized test method (broth or agar) Quantitative methods that require measurement of zone diameters also provide reproducible estimates of the susceptibility of bacteria to antimicrobial compounds. Historically, cefotaxime has been considered to be comparable to ceftriaxone (another third-generation cephalosporin) in safety and efficacy for the treatment of bacterial meningitis, lower respiratory tract infections, skin and soft tissue infections, genitourinary tract infections, and bloodstream infections, as well as prophylaxis for abdominal surgery.Cefotaxime is contraindicated in patients with a known hypersensitivity to cefotaxime or other cephalosporins.

In rare instances, extensive perivascular extravasation of Cefotaxime may result in tissue damage and require surgical treatment.

See Effective use for elective surgery depends on the time of administration. This effect is increased when you also use certain other medicines, including: antivirals, Other drugs may interact with cefotaxime, including prescription and over-the-counter medicines, Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.Copyright 1996-2018 Cerner Multum, Inc.

Cefotaxime is a β-lactam antibiotic (which refers to the structural components of the drug molecule itself). This is normal and does not affect the solution quality or safety. The dry material as well as solutions tend to darken depending on storage conditions and should be protected from elevated temperatures and excessive light.Peel overwrap at corner and remove solution container. Haemophilus. Mechanisms of resistance Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products.

Some opacity of the plastic due to moisture absorption during the sterilization process may be observed. This medicine is also given before, during, and after certain types of surgery to prevent infections.

Select one or more newsletters to continue. Solutions of Cefotaxime for injection range from very pale yellow to light amber depending on the concentration and the diluent used. The bactericidal properties are due to the inhibitory effect of cefotaxime on bacterial cell wall synthesis.

Keep this container out of the reach of children and pets.Use this medicine for the full prescribed length of time.

Other adverse reactions have been encountered infrequently.Local (4.3%) - Injection site inflammation with IV administration. It is possible that nephrotoxicity may be potentiated if Cefotaxime for Injection, USP is used concomitantly with an aminoglycoside.The administration of Cefotaxime for Injection, USP preoperatively reduces the incidence of certain infections in patients undergoing surgical procedures (e.g., abdominal or vaginal hysterectomy, gastrointestinal and genitourinary tract surgery) that may be classified as contaminated or potentially contaminated.In patients undergoing cesarean section, intraoperative (after clamping the umbilical cord) and postoperative use of Cefotaxime for Injection, USP may also reduce the incidence of certain postoperative infections. Keep thawed medicine in the refrigerator and use it within 10 days after thawing it. Follow any state or local laws about throwing away used needles and syringes. Cefotaxime is also used to prevent infections in people having surgery.

Because these reactions were reported voluntarily from a population of uncertain size, it is not possible to reliably estimate their frequency or establish a causal relationship to drug exposure.Cardiovascular System - Potentially life-threatening arrhythmias following rapid (less than 60 seconds) bolus administration via central venous catheter have been observed.Central Nervous System - Administration of high doses of beta-lactam antibiotics, including Cefotaxime, particularly in patients with renal insufficiency may result in encephalopathy (e.g. It is widely used to treat plant tissue infections with Gram-negative bacteria,O=C2N1/C(=C(\CS[C@@H]1[C@@H]2NC(=O)C(=N\OC)\c3nc(sc3)N)COC(=O)C)C(=O)OInChI=1S/C16H17N5O7S2/c1-6(22)28-3-7-4-29-14-10(13(24)21(14)11(7)15(25)26)19-12(23)9(20-27-2)8-5-30-16(17)18-8/h5,10,14H,3-4H2,1-2H3,(H2,17,18)(H,19,23)(H,25,26)/b20-9+/t10-,14-/m1/s1U.S. Food and Drug Administration. To minimize the potential for tissue inflammation, infusion sites should be monitored regularly and changed when appropriate.Patients should be counseled that antibacterial drugs including Cefotaxime for injection should only be used to treat bacterial infections.

Cefotaxime injection belongs to the class of medicines known as cephalosporin antibiotics. You may be shown how to use an IV at home.