The most common adverse reactions leading to discontinuation, defined as those occurring in at least 2% of Donepezil hydrochloride patients and at twice or more the incidence seen in placebo, were anorexia (2% vs. 1% placebo), nausea (2% vs. <1% placebo), diarrhea (2% vs. 0% placebo), and urinary tract infection (2% vs. 1% placebo).The most common adverse reactions, defined as those occurring at a frequency of at least 5% in patients receiving Donepezil hydrochloride and at twice or more the placebo rate, are largely predicted by Donepezil hydrochloride's cholinomimetic effects. Your doctor will write the number of refills authorized on your prescription.If you’re taking the orally disintegrating tablets, don’t swallow the tablets whole. Talk to your doctor about other drug options that may work for you.© 2005-2020 Healthline Media a Red Ventures Company. When compared with 65-year old subjects, 90-year old subjects have a 17% decrease in clearance, while 40 year old subjects have a 33% increase in clearance. Examples of these drugs include:When taken with donepezil, certain steroids can decrease the level of donepezil in your body. It comes as a regular oral tablet and an orally disintegrating tablet. Atypical responses in blood pressure and heart rate have been reported with other cholinomimetics when co-administered with quaternary anticholinergics such as glycopyrrolate. These adverse events were often transient, resolving during continued Donepezil hydrochloride treatment without the need for dose modification.There is evidence to suggest that the frequency of these common adverse reactions may be affected by the rate of titration. There was no evidence of a rebound effect 6 weeks after abrupt discontinuation of therapy.Figure 1. Increasing muscle weakness is a possibility and may result in death if respiratory muscles are involved. Taking them together can increase your risk of side effects. The differences in mean scores for Donepezil hydrochloride treated patients compared to the patients on placebo at Week 12 were 0.36 and 0.38 points for the 5 mg/day and 10 mg/day treatment groups, respectively. Read all information given to you. The SIB evaluates selective aspects of cognitive performance, including elements of memory, language, orientation, attention, praxis, visuospatial ability, construction, and social interaction. Although not all of these side effects may occur, if they do occur they may need medical attention. Approximately 1200 of these patients have been treated for at least 3 months and more than 1,000 patients have been treated for at least 6 months. There is a suggestion, however, based upon order of group mean scores and dose trend analyses of data from these clinical trials, that a daily dose of 10 mg of Donepezil hydrochloride might provide additional benefit for some patients. The ADCS-ADL-severe has a scoring range of 0 to 54, with the lower scores indicating greater functional impairment. These differences were statistically significant. Use the medicine exactly as directed.Remove an orally disintegrating tablet from the package only when you are ready to take the medicine.

Otherwise, please leave and close this page immediately! The ADAS-cog scoring range is from 0 to 70, with higher scores indicating greater cognitive impairment. Examples of these drugs include:These medications work similarly to donepezil. The SIB scoring range is from 0 to 100, with lower scores indicating greater cognitive impairment.Daily function was assessed using the Modified Alzheimer's Disease Cooperative Study Activities of Daily Living Inventory for Severe Alzheimer's Disease (ADCS-ADL-severe). Donepezil is used to help improve mental function in people with Donepezil does not work the same in all people. The 5 mg tablets are white, debossed with "OE" on one side and "645" on the other side.The 10 mg tablets are yellow, debossed with "OE" on one side and "648" on the other side.Although in most cases, these effects have been transient, sometimes lasting one to three weeks, and have resolved during continued use of Donepezil hydrochloride, patients should be observed closely at the initiation of treatment and after dose increases.Donepezil hydrochloride has been administered to over 1,700 individuals during clinical trials worldwide. Do not use two doses at one time.If you miss your doses for more than 7 days in a row, call your doctor before taking the medicine again.Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.Avoid driving or hazardous activity until you know how donepezil will affect you. Some people taking donepezil have improved mental function, while others may have unchanged or even worsening mental function.Donepezil is not a cure for Alzheimer's disease. Donepezil oral tablet is a prescription medication that’s used to treat dementia caused by Alzheimer’s disease. You may report side effects to FDA at 1-800-FDA-1088.How should Donepezil hydrochloride tablets be stored?Keep Donepezil hydrochloride tablets and all medicines out of the reach of children.General information about Donepezil hydrochloride tablets.Inactive ingredients in Donepezil hydrochloride, 5 mg and 10 mg film-coated tablets:We comply with the HONcode standard for trustworthy health information - If you take them together, the drugs may be less effective. It appears to result in a small benefit in mental function and ability to function. Donepezil hydrochloride tablets can help with mental function and with doing daily tasks. Clinical trials for investigational drugs have used a variety of CIBIC formats, each different in terms of depth and structure.As such, results from a CIBIC-plus reflect clinical experience from the trial or trials in which it was used and cannot be compared directly with the results of CIBIC-plus evaluations from other clinical trials. Our general interest e-newsletter keeps you up to date on a wide variety of health topics.Along with its needed effects, a medicine may cause some unwanted effects.