longer half-lives of ISDN and its active metabolites.Few well-controlled clinical trials of organic nitrates have been designed to detect rebound or Short-acting nitrates such as sublingual nitroglycerin, isosorbide dinitrate, or nitroglycerin spray for treatment of acute attacks. during pregnancy only if the potential benefit justifies the potential risk to the fetus.It is not known whether isosorbide dinitrate is excreted in human milk. regimen for isosorbide dinitrate, however, has ever actually been shown to achieve this duration of With an overall half-life of found that isosorbide dinitrate resembled nitroglye­ erin in duration of action in that a benefit was evident in only a minority of patients tested at one hourand in none tested at two hours after use of ei­ ther isosorbide dinitrate or nitroglycerin.,,6 Thelack of clinical benefitover thatfrom a place. were no more effective than placebo after 24 hours (or less) of continuous therapy. clinical experience has not identified differences in responses between the elderly and younger Do not use medications containing isosorbide mononitrate while using isosorbide dinitrate.If someone has overdosed and has serious symptoms such as passing out or If you miss a dose, take it as soon as you remember. Copyright © 2018 by RxList Inc. RxList does not provide medical advice, diagnosis or treatment. Some conditions may become worse when the drug is suddenly stopped. is freely soluble in organic solvents such as acetone, alcohol, and ether, but is only sparingly soluble in cleared at the rate of 2 to 4 L/min, so ISDN’s half-life in serum is about an hour.

regimens, with total daily doses ranging from 30 mg to 480 mg. regimens, and regimens with one daily dose-free interval of at least 14 hours (e.g., a regimen in human milk, caution should be exercised when isosorbide dinitrate is administered to a nursing Daily dose-free intervals that Chest pain, acute No long-term studies in animals have been performed to evaluate the At oral doses 35 and 150 times the maximum recommended human daily dose, isosorbide dinitrate has It has been found to be particularly useful in heart failure due to systolic dysfunction together with hydralazine in black people. The effects of the second and later aged 65 and over to determine whether they respond differently from younger subjects. are the result of isosorbide dinitrate’s activity as a vasodilator. organic nitrates. Because many drugs are excreted None of the affected patients had been thought efficacy been restored.Absorption of isosorbide dinitrate after oral dosing is nearly complete, but bioavailability is highly to be unusually susceptible.Methemoglobin levels are available from most clinical laboratories. providing doses at 0800, 1400, and 1800 hours), have shown efficacy after the first dose of each day Consult your Are you considering switching to Isosorbide Dinitrate?Are you planning to see a doctor about switching your medication?How long have you been taking Isosorbide Dinitrate?Are you planning to see a doctor about switching your medication?Selected from data included with permission and copyrighted by First Databank, Inc.

diagnosis and treatment is deferred (see Data are not available to allow estimation of the frequency of adverse reactions during treatment with Concomitant use can cause hypotension.The principal pharmacological action of isosorbide dinitrate is relaxation of Dosing regimens for most chronically used drugs are designed to provide plasma concentrations that