Each case involved the use of 1 or more dipeptidyl peptidase-4 (DPP-4) inhibitor.

Concomitant cardiovascular or Signs and symptoms of severe acidosis may include vomiting, abdominal pain, nausea, Long-term treatment with metformin has been associated with a decrease in vitamin B12 absorption. The reduction in vitamin B12 levels may be due to interference with B12 absorption from the B12-intrinsic factor complex and appears to be rapidly reversible with discontinuation of metformin or vitamin B12 supplementation.1.

© 1998-2020 Mayo Foundation for Medical Education and Research (MFMER). Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes.Mayo Clinic does not endorse companies or products. Swelling Of The Abdomen 8. Some side effects go away as the body adjusts to the medication. In some cases, this may lead to type 2 diabetes. Rare side effects. All rights reserved. Some people have developed memory loss or confusion while taking Crestor. A Common Cold 2. Vomiting 10. Crestor; Descriptions. Liver function tests are recommended prior to starting therapy and at periodic intervals throughout therapy. Common side effects of Crestor include: myalgia.Other side effects include: asthenia. Statins are tolerated well by most people, but they can have side effects. Available from: URL: http://www.fda.gov/downloads/Drugs/DrugSafety/UCM460038.pdf."

Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. If experienced, these tend to have a Less Severe expression 1. Some of the dosage forms listed on this page may not apply to the brand name Crestor.. These side effects reverse once you stop taking the medication. This medicine is available only with your doctor's prescription. Available for Android and iOS devices.We comply with the HONcode standard for trustworthy health information - Inadequate Vitamin B12 6. US Food and Drug Administration "FDA Drug Safety Communication: FDA warns that DPP-4 inhibitors for type 2 diabetes may cause severe joint pain. It may also be used to prevent certain types of heart and blood vessel problems in patients with risk factors for heart problems. Nausea 7.

"Product Information. Decreased levels of vitamin B12 appear to be reversible with discontinuation of metformin or vitamin B12 supplementation.Between October 2006 and December 2013, thirty-three cases of severe arthralgia have been reported to the FDA Adverse Event Reporting System Database. In all cases, substantial reduction in prior activity level was reported, 10 patients were hospitalized due to disabling joint pain. Sitagliptin had the greatest number of cases reported (n=28) followed by Decreased serum vitamin B12 levels, without clinical manifestations (rarely megaloblastic anemia), has been reported in approximately 7% of patients. Weight Loss See below for a comprehensive list of adverse effects. Crestor may cause your blood sugar level to increase. You may report them to the The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records.

Note: This document contains side effect information about rosuvastatin. Janumet (metformin-sitagliptin)." In Summary. There is limited evidence to prove a cause-effect relationship, but talk to your doctor if you experience memory loss or confusion while taking statins. Rosuvastatin may help prevent or slow down medical problems, like atherosclerosis (hardening of the arteries), that are caused by fats clogging the blood vessels. Our general interest e-newsletter keeps you up to date on a wide variety of health topics.Rosuvastatin is used together with a proper diet to lower bad cholesterol (LDL) and triglycerides (fats) in the blood, and to increase your good cholesterol (HDL). Along with its needed effects, metformin / sitagliptin may cause some unwanted effects.

All rights reserved. Other side effects include: nausea. Rosuvastatin belongs to a group of medicines called HMG-CoA reductase inhibitors, or statins. Common side effects of Janumet include: lactic acidosis. Headache 5. In 22 cases, symptoms appeared within 1 month of starting therapy, in 23 cases symptoms resolved less than 1 month after discontinuation. Rosuvastatin is used together with a proper diet to lower bad cholesterol (LDL) and triglycerides (fats) in the blood, and to increase your good cholesterol (HDL). Merck & Company Inc, West Point, PA. 2.

It is also used to treat adults who cannot control their cholesterol levels by diet and exercise alone. Description and Brand Names. A positive rechallenge was reported in 8 cases, with 6 cases involving use of a different DPP-4 inhibitor. It works by blocking an enzyme that is needed by the body to make cholesterol, so this reduces the amount of cholesterol in the blood. Crestor, like other statins, may affect liver function, manifesting as changes in liver function tests or jaundice (yellowing of the skin) requiring dosage reduction or discontinuation. Megaloblastic anemia has occurred. This product is available in the following dosage forms:Portions of this document last updated: Sept. 01, 2020Copyright © 2020 IBM Watson Health. The risk of lactic acidosis has been particularly high in patients with underlying renal insufficiency and rarely in patients with normal renal function. Although not all of these side effects may occur, if they do occur they may need medical attention.Some side effects of metformin / sitagliptin may occur that usually Check with your health care professional if any of the following side effects In metformin-treated patients, the incidence of lactic acidosis has been about 1.5 cases per 10,000 patient years.

Diarrhea 3. Taste Impairment 9. But tell your doctor about any unusual signs or symptoms you might have after starting statin therapy. Your doctor may want to decrease your dose or try a different statin. Drug information provided by: IBM Micromedex US Brand Name. Gas 4.