The efficacy of Effexor XR (venlafaxine hydrochloride) extended-release capsules as a treatment for Major Depressive Disorder (MDD) was established in two placebo-controlled, short-term (8 weeks for study 1; 12 weeks for study 2), flexible-dose studies, with doses starting at 75 mg per day and ranging to 225 mg per day in adult outpatients meeting DSM-III-R or DSM-IV criteria for MDD.
Symptoms can include anxiety, shakiness, fever, diarrhea, fast heartbeat, and seizures.If you experience any symptoms of serotonin syndrome, tell your doctor right away. )The short-acting form of venlafaxine comes as a tablet. Response during the open phase was defined as ≤ 1 full-symptom panic attack per week during the last 2 weeks of the open phase and a CGI Improvement score of 1 (very much improved) or 2 (much improved). Don’t stop taking Effexor XR unless your doctor recommends that you do so.You may be able to switch from a short-acting form of venlafaxine to Effexor XR if your doctor recommends that you do.
Symptoms include:Venlafaxine may also be helpful when prescribed “off-label” for attention-deficit/hyperactivity disorder (ADHD) in adults and children/adolescents, diabetic neuropathy, migraine prevention, hot flashes, obsessive compulsive disorder (OCD), posttraumatic stress disorder (PTSD), and premenstrual dysphoric disorder (PMDD) . Whether or not higher doses of Effexor XR are needed for more severely depressed patients is unknown; however, the experience with Effexor XR doses higher than 225 mg per day is very limited.For most patients, the recommended starting dose for Effexor XR is 75 mg per day, administered in a single dose. Symptoms can include If you experience any symptoms of serotonin syndrome, tell your doctor right away. MDD is a condition that’s thought to be caused by a chemical imbalance in your brain. The insurance company will review the request and let you and your doctor know if your plan will cover Effexor XR.If you’re not sure if you’ll need to get prior authorization for Effexor XR, contact your insurance company.If you need financial support to pay for Effexor XR, or if you need help understanding your insurance coverage, help is available.Pfizer, Inc., the manufacturer of Effexor XR, offers a copay savings program, which may help lower the cost of Effexor XR. Subsequently, the physician may continue decreasing the dose, but at a more gradual rate This list does not contain all drugs that may interact with Effexor XR.Before taking Effexor XR, talk with your doctor and pharmacist. Symptoms can include anxiety, shakiness, fever, diarrhea, fast heartbeat, and seizures.If you experience any symptoms of serotonin syndrome, tell your doctor right away. If intolerable symptoms occur following a decrease in the dose or upon discontinuation of treatment, then resuming the previously prescribed dose may be considered. There are also other side effect concerns if children take this drug.In the studies, 18% to 47% of children who took Effexor XR lost at least 3.5% of their total body weight. Drug release is controlled by diffusion through the coating membrane on the spheroids and is not pH-dependent. This increase was duration dependent over the study period and tended to be greater with higher doses. Efexor … In some cases, a patient already receiving Effexor XR therapy may require urgent treatment with linezolid or intravenous methylene blue. Other interactions can increase side effects or make them more severe.Below is a list of medications that can interact with Effexor XR. For some patients, it may be desirable to start at 37.5 mg per day for 4 to 7 days to allow new patients to adjust to the medication before increasing to 75 mg per day. Call your doctor right away if you have serious side effects. This may include gums that bleed more easily, nose bleed, or gastrointestinal bleeding. Camber Pharmaceuticals is pleased to announce that it has launched Venlafaxine Hydrochloride ER capsules, which is the generic version of Effexor XR® capsules from Wyeth Pharmaceuticals. Efficacy was established in two 8-week and two 26-week placebo-controlled trials.Effexor XR is indicated for the treatment of Social Anxiety Disorder (SAD), also known as social phobia. Patients with major depressive disorder (MDD), both adult and pediatric, may experience worsening of their depression and/or the emergence of suicidal ideation and behavior (suicidality) or unusual changes in behavior, whether or not they are taking antidepressant medications, and this risk may persist until significant remission occurs. Adverse Reactions Reported as Reasons for Discontinuation of TreatmentTable 7: Incidence (%) of Patients Reporting Adverse Reactions Leading to Discontinuation in Placebo-controlled Clinical Studies (up to 12 Weeks Duration)Common Adverse Reactions in Placebo-controlled StudiesTable 8: Patients Receiving Effexor XR in Premarketing Clinical StudiesTable 9: Common Adverse Reactions: Percentage of Patients Reporting Adverse Reactions (≥ 2% and > placebo) in Placebo-controlled Studies (up to 12 Weeks Duration) across All IndicationsOther Adverse Reactions Observed in Clinical StudiesTable 10: Final On-therapy Mean Changes From Baseline in Supine Systolic (SSBP) and Diastolic (SDBP) Blood Pressure (mm Hg) in Placebo-controlled StudiesTable 11: Sustained Elevations in SDBP in Effexor XR Premarketing StudiesTable 12: Approximate Mean Final On-therapy Increase in Pulse Rate (beats/min) in Effexor XR Premarketing Placebo-controlled Studies (up to 12 Weeks Duration)Table 13: Mean Final On-therapy Changes in Cholesterol Concentrations (mg/dL) in Effexor XR Premarketing StudiesTable 14: Mean Final On-therapy Increases in Triglyceride Concentrations (mg/dL) in Effexor XR Premarketing StudiesFigure 1: Effect of interacting drugs on the pharmacokinetics of venlafaxine and active metabolite O-desmethylvenlafaxine (ODV). to 1.7 lbs.