In children, the dosage is also based on age and Use this medication regularly to get the most benefit from it. Do not store in the bathroom. Ask your doctor about foods high in potassium (such as bananas, orange juice) or about using a salt substitute containing potassium. PITTS RF, KRUCK F, LOZANO R, TAYLOR DW, HEIDENREICH OP, KESSLER RH. If you notice other effects not listed above, contact your doctor or pharmacist.Call your doctor for medical advice about side effects. THE MECHANISM OF ACTION OF CHLOROTHIAZIDE. Consult your Are you planning to see a doctor about switching your medication?Are you planning to see a doctor about switching your medication?Selected from data included with permission and copyrighted by First Databank, Inc. 2008. accessed online at Aung K, Htay T. Thiazide diuretics and the risk of hip fracture. A mechanism of chlorothiazide-enhanced effectiveness of antihypertensive ganglioplegic drugs. A potassium supplement may be prescribed by your doctor.This medication may make you more sensitive to the sun. 1958 Jun; 123 (2):89–97. Avoid tanning booths and sunlamps. Properly discard this product when it is expired or no longer needed.

Ann N Y Acad Sci. They augment the excretion of water, salt, and to a lesser extent K+ and HCO 3 ‐ ions. Comparative effects of chlorothiazide and mersalyl (mersalyl sodium and theophylline) on the kidney. Cochrane Database of Systematic Reviews 2011, Issue 10. Do not double the dose to catch up.Store at room temperature away from light and moisture. DUSTAN HP, CUMMING GR, CORCORAN AC, PAGE IH. This medication is also used to decrease swelling (If you are using the liquid form of this medication, carefully measure the dose using a special measuring device/spoon.

Art. The central nervous control of food and water intake. They combine the saluretic action of the organic mercurials with the carbonic anhydrase inhibitory action of sulfonamyl compounds. The Merck Institute for Therapeutic Research, West Point, Pa. Search for more papers by this author. Do not use a household spoon because you may not get the correct dose. Therapie, Die Analyse der Nierenfunktion Grundlagen und klinischer Aussagewert, Ergebnisse der Inneren Medizin und Kinderheilkunde, Sulfonamide compounds with high diuretic activity, The effect of chlorothiazide on human gastric secretion, Experimentell-Klinische Untersuchungen �ber Hydrochlorothiazid (Esidrex), ein neues diuretisch wirksames Sulfonamid, A controlled study of chlorothiazide as a diuretic agent, Effect of Chlorothiazide Therapy on Serum Uric Acid and Uric Acid Excretion, Diuretic therapy in syndromes associated with sodium and water retention∗, The pharmacology of hydrochlorothiazide (Esidrix™), a new, orally effective sulfonamide diuretic, Chlorothiazide as an adjunct in the treatment of essential hypertension, Allgemeine Nebenwirkungen der diuretischen Therapie, Diuretische und saluretische Wirkungen von Chlorothiazid unter normalen und pathologischen Bedingungen, Über den Wirkungsmechanismus eines neuen Diuretikums (Hydrochlorothiacid), Some reflections on mechanisms of action of diuretics, This discovery led to further research into the mechanism of action of chlorothiazide, which was found to act by inhibiting an electroneutral Na/Cl symporter in the upstream portion of the distal tubule (Ernst & Moser, 2009). 219 In addition, it decreases renal calcium excretion compared to loop diuretics. Hydrochlorothiazide is a diuretic and antihypertensive. Studies on the mechanism of diuretic action of chlorothiazide. Chlorothiazide, a potent oral diuretic, has its major site of action in the proximal portion of the distal tubule 210; it acts by inhibiting chloride reabsorption. Use Older adults may be more sensitive to the side effects of this drug, especially Some products that may interact with this drug are: Some products have ingredients that could raise your This product may interfere with certain lab tests. Many people using this medication do not have serious side effects.This medication can cause a loss of too much body water (Tell your doctor right away if you have any serious side effects, such as: Get medical help right away if you have any very serious side effects, such as: decrease in This is not a complete list of possible side effects. It is chemically designated as 6-chloro-3,4-dihydro-2 H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide and it has the following structural formula: It reduces blood volume by acting on the kidneys to reduce sodium (Na +) reabsorption in the distal convoluted tubule. carbonic anhydrase.3 The effectiveness of chlorothiazide in the management of hypertension was first announced in 1957.4-5 The mechanism of action proposed for chlorothiazide appears to be common to all drugs of this class and includes increased excretion of potassium. It is the 3,4-dihydro derivative of chlorothiazide. Chlorothiazide, by virtue of its activity as an inhibitor of carbonic anhydrase, induces … DOLLERY CT, HARINGTON M, KAUFMANN G. The mode of action of chlorothiazide in hypertension: with special reference to potentiation of ganglion-blocking agents. Mechanism of action/Effect: Diuretic—Thiazide diuretics increase urinary excretion of sodium and water by inhibiting sodium reabsorption in the early distal tubules {04}. Chlorothiazide is …

Mechanism of action. Thiazide organic molecules are bi-cyclic structures that contain adjacent sulfur and nitrogen atoms on one ring.Thiazides and thiazide-like diuretics have been in constant use since their introduction in 1958. Make sure lab personnel and all your doctors know you use this drug.If someone has overdosed and has serious symptoms such as passing out or Lifestyle changes that may help this medication work better include If you miss a dose, take it as soon as you remember. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. BEYER KH. Karl H. Beyer. A mechanism of chlorothiazide-enhanced effectiveness of antihypertensive ganglioplegic drugs. DOI: 10.1002/14651858.CD005185.pub2. No. 1958 Feb 3; 71 (4):363–379. Hydrochlorothiazide belongs to thiazide class of diuretics.