Search for other works by this author on: Medications such as hydralazine, procainamide, methyldopa, chlorpromazine, quinidine, and minocycline are known to cause SLE. Byrne PAC, Williams BD, Pritchard MH. Quilty B, McHugh N. Lupus‐like syndrome associated with the use of minocycline. The spectrum of DIL constantly evolves with that of the pharmacopoeia. Association of antibody to histone complex H2A‐H2B with symptomatic procainamide‐induced lupus. Matsuura T, Shimizu Y, Fujimoto H, Miyazaki T, Kano S. Minocycline‐related lupus. We highlight the wide spectrum of clinical features associated with this syndrome, which range from polyarthralgia to features typical of idiopathic systemic lupus erythematosus (SLE).The role of rechallenge with minocycline in the diagnosis of MIL has not been studied objectively, although some patients have performed their own rechallenge before seeking medical advice and noted recurrence of symptoms [The patients were seen between 1994 and 2000 and were referred by general practitioners or consultant colleagues or were self‐referrals following reports in the popular press of MIL. Schlienger RG, Bircher AJ, Meier CR. Gough A, Chapman S, Wagstaff K, Emery P, Elias E. Minocycline induced autoimmune hepatitis and systemic lupus erythematosus‐like syndrome. It is taken by mouth. In vetting diagnostic criteria, it is important to consider how more sophisticated testing may exacerbate existing disparities in diagnosis, treatment, and research,” says Ashira D. Blazer, MD, MSCI, assistant professor in the Department of Medicine, Division of Rheumatology at NYU School of Medicine and the study’s lead author. Five years after stopping minocycline, she is positive for ANA (1:1600), but negative for anti‐dsDNA antibodies. Twenty‐two subjects were taking minocycline at a dose of 100 mg daily for the treatment of acne vulgaris. His failure to improve after withdrawal of the minocycline raised some doubt about the diagnosis. Nine months later, he complained of weight loss and general malaise and after a further 3 months became jaundiced. In the Ghanaian cohort, the average age was 32 years, all were women, the mean SLE disease duration was 2.2 years; and 85 percent met the ACR criteria, 84 percent met the SLICC criteria and 62 percent met the ACR/EULAR criteria.

These findings were enlightening, and they solidified an important concept: that SLE is a clinical diagnosis first,” says Dr. Blazer. Dunphy J, Oliver M, Rands AL, Lovell CR, McHugh NJ. The patient refused rechallenge with minocycline.This is the first case of MIL to be described in a patient taking minocycline for RA, a situation in which worsening joint symptoms could easily be misinterpreted as an exacerbation of RA.Twenty‐three patients (20 female, three male) have been identified in our unit. Knowles SR, Shapiro L, Shear NH. Initial investigations confirmed hepatitis [bilirubin 120 He subsequently developed severe polyarthralgia and myalgia, and was unable to dress without assistance. Comparative safety of tetracycline, minocycline and doxycycline. Singer SJ, Piazza‐Hepp TD, Girardi LS, Moledina NR.

Untargeted lipidomics reveals specific lipid abnormalities in Sjögren’s syndrome Minocycline‐induced arthritis. Her RA was subsequently treated with methotrexate and remains well controlled. She also complained of malaise, impaired concentration, Raynaud's phenomenon, alopecia, mouth ulcers and altered sensation over the left foot. Association of differentially expressed genes and autoantibody type in patients with systemic sclerosis Minocycline‐related lupus. Boudreaux J, Hayes D, Mizrahi S, Hussey J, Regenstein F, Balart L. Fulminant hepatic failure, hepatorenal syndrome, necrotizing pancreatitis after minocycline hepatotoxicity.

Transformation of lupus‐inducing drugs to cytotoxic products by activated neutrophils. Shapiro LE, Knowles SR, Shear NH. Baillière's Reidenberg MM.