However, patients with known CV disease or risk factors had a higher absolute incidence of excess serious CV thrombotic events, due to their increased baseline rate.

Apply enough Diclofenac Sodium Gel to cover each skin lesion and gently rub in. The elderly, people with impaired renal function, heart failure, liver dysfunction, and those taking diuretics and ACE inhibitors should be cautious when using Voltaren Gel.
Call your doctor for medical Open the safety seal by firmly pressing the point on the top of the cap onto the seal on the tube. Upper GI ulcers, gross bleeding, or perforation caused by NSAIDs occurred in approximately 1% of patients treated for 3-6 months, and in about 2%-4% of patients treated for one year. You may have an increased risk of another heart attack if you take NSAIDs after a recent heart attack. Of these, 513 patients received diclofenac sodium topical gel for osteoarthritis of the knee and 400 were treated for osteoarthritis of the hand. Diclofenac sodium topical gel is indicated for the relief of the pain of osteoarthritis of joints amenable to topical treatment, such as the knees and those of the hands.Use the lowest effective dosage for the shortest duration consistent with individual patient treatment goals [The dosing card can be found attached to the inside of the carton.Apply the gel (4 g) to the affected foot, ankle, or knee 4 times daily.

Of these, 513 patients received diclofenac sodium topical gel for osteoarthritis of the knee and 400 were treated for osteoarthritis of the hand. Do not use on more than 2 body areas at once.Gently rub Diclofenac Sodium Topical Gel, 1% into the skin using your hand. Available for Android and iOS devices. Non-serious Application Site Adverse Reactions (≥1% diclofenac sodium topical gel Patients) – Short-term Controlled TrialsTable 2:  Clinically Significant Drug Interactions with DiclofenacACE Inhibitors, Angiotensin Receptor Blockers, and Beta-BlockersTable 3.
The optimum times for making the first and subsequent transaminase measurements are not known. (Basis: treatment with diclofenac sodium topical gel of 1 knee, 4 times a day versus 50 mg, 3 times a day of oral diclofenac tablets.)

Pharmacokinetic Parameters and Comparison of diclofenac sodium topical gel to Oral Diclofenac Sodium Tablets After Repeated AdministrationTable 4. Diclofenac sodium. Duration of exposure ranged from 8 to 12 weeks for the placebo-controlled studies, and up to 12 months for the open-label safety trial.Table 1 lists the types of application site reactions reported. Each tube contains diclofenac sodium in a gel base (10 mg of diclofenac sodium per gram of gel or 1%).Store at room temperature 68°F to 77°F (20°C to 25°C) [See USP Controlled Room Temperature].Keep from freezing. Just apply the next dose as scheduled.Compare to Voltaren® Arthritis Pain active ingredient Patients should be informed about the symptoms of serious CV events and the steps to take if they occur.There is no consistent evidence that concurrent use of aspirin mitigates the increased risk of serious CV thrombotic events associated with NSAID use. The program should also include activities such as appropriate movement or exercise, specific lifestyle changes, and weight maintenance. Concomitant use may result in skin reactions or change the absorption of diclofenac sodium topical gel.Instruct patients to minimize or avoid exposure of treated areas to natural or artificial sunlight [Your healthcare provider has prescribed diclofenac sodium topical gel to help relieve arthritis pain in some of your joints. Some of these reported cases resulted in fatalities or liver transplantation.In a European retrospective population-based, case-controlled study, 10 cases of diclofenac associated drug-induced liver injury with current use compared with non-use of diclofenac were associated with a statistically significant 4-fold adjusted odds ratio of liver injury. "Avoid taking NSAIDs after a recent heart attack, unless your healthcare provider tells you to.