Memory loss is a major concern of the elderly.
Any erosion of self-confidence can lead to depression, noncompliance, and morbidity. Gutierrez A, Khan ZU, Ruano D, Miralles CP, Vitorica J, De Blas AL. This sheet provides information about how these drugs work as well as the impact that they may have in respect to dementia risk and cognitive functioning.
Neuroscience 1996;74:341-8. Drug facts and comparisons.
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startxref 0000009684 00000 n An abundance of studies suggests that benzodiazepine use is directly related …
To see the full article, log in or purchase access.Olshansky SJ, Carnes BA, Cassel CK. Possible conflicts of interest must be disclosed at time of submission.
0000006350 00000 n patients, elderly patients may have a less severe withdrawal syndrome associated with gradual tapering of the dose, pos sibly because the slower clearance of the drug in elderly patients attenuates withdrawal symptoms. %PDF-1.7 %���� 0000011971 00000 n 0000024592 00000 n 0000013930 00000 n J Comp Neurol 1997;379:455-65. An increasing number of elderly patients undergo "minor surgeries. endstream endobj 38 0 obj <> endobj 39 0 obj <> endobj 40 0 obj <> endobj 41 0 obj <>/Font<>/ProcSet[/PDF/Text/ImageB]>>/Type/Page>> endobj 42 0 obj <> endobj 43 0 obj <> endobj 44 0 obj <> endobj 45 0 obj <> endobj 46 0 obj <>stream
Second and, most important, the patient, family members, and caretakers should be prepared for the amnesic effects and appreciate the significance of these experiences for the elderly patient. 0000001453 00000 n �iͩ1)��^Z���W"�]�!��xL�`��-�����뿇�����{��!����rFy�����O�eB�9�� �eQ�~P�Px�ѻ>��B>+ĸ First, lower doses may be necessary in the elderly because of altered pharmacokinetic and pharmacodynamic properties.
0000174117 00000 n 0000001503 00000 n 0000003993 00000 n 0000002940 00000 n If elderly patients are not informed about the amnesic actions of these agents, they may have significant difficulty following surgery. The amnesic effects are selective in nature, which can distort reality and be disorienting to the patient, even cognitively intact persons.We are not suggesting that the use of benzodiazepines is inappropriate in elderly patients, but we wish to strongly make two points. Thus, clinicians, patients, and family members may have difficulty recognizing them or may assume that they are psychopathologic changes rather than drug induced effects. 14 Addiction.-Addictionto benzodiazepines is another ad verse consequence of their use… 0000038085 00000 n St. Louis: Facts and Comparisons, 2001. Sci Am 1993;268:46-52.
In this case, the relatively minor and well-recognized effect of benzodiazepine on memory resulted in serious consequences.An increasing number of elderly patients undergo "minor surgeries. Submission of a letter will be construed as granting the AAFP permission to publish the letter in any of its publications in any form. Some of these cases may relate to the use of amnesic benzodiazepines. 0000012954 00000 n Aging-related subunit expression changes of the GABAA receptor in the rat hippocampus.
Purpose: Some studies have suggested that the use of benzodiazepines in the elderly is associated with an increased risk of dementia.However, this association might be due to confounding by indication and reverse causation. 0000000016 00000 n 0000008637 00000 n
0000005289 00000 n
The problems that arise with the use of benzodiazepines in the elderly may be subtle. To examine the association between benzodiazepine anxiolytic drug use and the risk of dementia, we conducted data mining of a spontaneous reporting database and a …
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Benzodiazepine oxidation is decreased in persons with liver disease and the elderly. 0 Vision problems; High addiction potential; The risk of experiencing adverse effects is significantly elevated in the elderly, which includes the majority of dementia patients.
Albrecht S, Ihmsen H, Hering W, Geisslinger G, Dingemanse J, Schwilden H. The effect of age on the pharmacokinetics and pharmacodynamics of midazolam. 0000007398 00000 n
trailer "1 Short-acting benzodiazepines have significant advantages over general anesthesia. xref The aging of the human species. Chlordiazepoxide and diazepam are first metabolized by hepatic oxidation, then glucuronidation.
0000010927 00000 n Ruano D, Araujo F, Revilla E, Vela J, Bergis O, Vitorica J. GABAA and alpha-amino-3-hydroxy-5-methylosoxazole-4-propionate receptors are differentially affected by aging in the rat hippocampus. 69 0 obj <>stream 0000176998 00000 n 0000009929 00000 n