Each tablet contains the labeled amount of bupropion hydrochloride and the inactive ingredients: ethylcellulose aqueous dispersion,glyceryl behenate, methacrylic acid copolymer dispersion, polyvinyl alcohol, polyethylene glycol, povidone, silicon dioxide, and triethyl citrate. In a patient who requires more urgent treatment of a psychiatric condition, non-pharmacological interventions, including hospitalization, should be considered In some cases, a patient already receiving therapy with Wellbutrin XL may require urgent treatment with linezolid or intravenous methylene blue. Monitoring of blood pressure is recommended in patients who receive the combination of bupropion and nicotine replacement.In the 3 trials of bupropion HCl extended-release in seasonal affective disorder, there were significant elevations in blood pressure. 0000015394 00000 n The risk of seizure can be reduced if the Wellbutrin XL dose does not exceed 450 mg once daily and the titration rate is gradual.Treatment with Wellbutrin XL can result in elevated blood pressure and hypertension. On the other hand, those with low BMRs may have more body fat, ultimately increasing distribution of bupropion throughout the body – resulting in a slower detoxification.The duration over which a person has taken Wellbutrin can affect how long it remains in their system after stopping. Read it with care. If you’ve been taking the drug for awhile, you’re probably aware that it may have accumulated within bodily tissues (e.g. Peak plasma concentrations of bupropion appear approximately 5 hours post-ingestion of the “XL” (extended-release) version, 3 hours post-ingestion of the “SR” (sustained-release) version, and 1.5 hours post-ingestion of the “IR” (immediate-release) version. And if you are not in psychotherapy, find a therapist in the directory and schedule some appointments. 0000014380 00000 n %PDF-1.5 %���� The molecular formula is CWellbutrin XL tablets are supplied for oral administration as 150 mg and 300 mg creamy-white to pale yellow extended-release tablets. The tablets are printed with edible black ink.Wellbutrin XL is a registered trademark of GlaxoSmithKline LLC used under license.APLENZIN is a trademark of Bausch Health Companies Inc. or its affiliates.All other product/brand names are the trademarks of the respective owners.© 2020 Bausch Health Companies Inc. or its affiliatesThis Medication Guide has been approved by the U.S. Food and Drug Administration.The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. It is well-documented that hepatic impairment can prolong the elimination of bupropion from the plasma, as well as its metabolite… At least 14 days should elapse between discontinuation of an MAOI intended to treat depression and initiation of treatment with Wellbutrin XL. Wellbutrin XL (buproprion) Full Prescribing Information ... taken as 100 milligrams 3 times a day, with at least 6 hours between doses. The mean increase in diastolic blood pressure was 0.8 mmHg in the bupropion group and 0.1 mmHg in the placebo group. 0000007099 00000 n 0000011763 00000 n Particularly, the greater the dosage that you ingested per day, the longer you can expect the drug to remain in your system after discontinuation. The primary analysis was a comparison of depression-free rates between the bupropion and placebo groups.In these 3 trials, the percentage of patients who were depression-free (did not have an episode of MDD) at the end of treatment was significantly higher in the bupropion group than in the placebo group: 81.4% vs. 69.7%, 87.2% vs. 78.7%, and 84.0% vs. 69.0% for Trials 1, 2 and 3, respectively. Some people can have severe allergic reactions to Wellbutrin XL.

Pre-existing glaucoma is almost always open-angle glaucoma because angle-closure glaucoma, when diagnosed, can be treated definitively with iridectomy. Multiple uncontrolled seizures, bradycardia, cardiac failure, and cardiac arrest prior to death were reported in these patients.Consult a Certified Poison Control Center for up-to-date guidance and advice. Wellbutrin XL is contraindicated in patients with a seizure disorder or conditions that increase the risk of seizure (e.g., severe head injury, arteriovenous malformation, CNS tumor or CNS infection, severe stroke, anorexia nervosa or bulimia, or abrupt discontinuation of alcohol, benzodiazepines, barbiturates, and antiepileptic drugs The incidence of seizure with Wellbutrin XL has not been formally evaluated in clinical trials.

In a study of 8 healthy male volunteers, following a 14-day administration of bupropion 100 mg three times per day, there was no evidence of induction of its own metabolism. However, more variability was observed in some of the pharmacokinetic parameters for bupropion (AUC, CDuring a chronic dosing study with bupropion in 14 depressed patients with left ventricular dysfunction (history of CHF or an enlarged heart on x-ray), there was no apparent effect on the pharmacokinetics of bupropion or its metabolites, compared to healthy volunteers.The effects of age on the pharmacokinetics of bupropion and its metabolites have not been fully characterized, but an exploration of steady-state bupropion concentrations from several depression efficacy studies involving patients dosed in a range of 300 to 750 mg/day, on a 3 times daily schedule, revealed no relationship between age (18 to 83 years) and plasma concentration of bupropion. The women who discontinued antidepressants during pregnancy were more likely to experience a relapse of major depression than women who continued antidepressants. One study compared the elimination half-life of bupropion (and its metabolites) among those with alcoholic liver disease to those with normative liver function. Response during the open-label phase was defined as a CGI-Improvement Scale score of 1 (very much improved) or 2 (much improved) for each of the final 3 weeks. In rats, bupropion produced amphetamine-like and cocaine-like discriminative stimulus effects in drug discrimination paradigms used to characterize the subjective effects of psychoactive drugs.Overdoses of up to 30 grams or more of bupropion have been reported.

Following single oral administration of Wellbutrin XL tablets to healthy volunteers, the median time to peak plasma concentrations for bupropion was approximately 5 hours.