In some rabbit studies, an overall increase in fetal loss (dead and resorbed conceptuses) was associated with doses of trimethoprim 6 times the human therapeutic dose based on body surface area.There may be an increased risk of severe adverse reactions in elderly patients, particularly when complicating conditions exist, e.g., impaired kidney and/or liver function, possible folate deficiency, or concomitant use of other drugs. 1.1.2 . Cellulitis is often easily treated with a course of antibiotics. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records.

Sulfamethoxazole and trimethoprim are are both antibiotics that treat different types of infection caused by bacteria. However, after normalizing by body weight, the apparent total body clearance of trimethoprim was on average 19% lower in geriatric subjects compared with young adult subjects.Sulfamethoxazole inhibits bacterial synthesis of dihydrofolic acid by competing with Trimethoprim/sulfamethoxazole has been shown to be active against most isolates of the following microorganisms, both in When available, the clinical microbiology laboratory should provide cumulative reports of Quantitative methods that require measurement of zone diameters can also provide reproducible estimates of the susceptibility of bacteria to antimicrobial compounds. No significant association between antibiotic prescription and development of orbital cellulitis following AS were found (OR 0.56; 95% CI = 0.27 to 1.12). In rare instances, a skin rash may be followed by a more severe reaction, such as Stevens-Johnson syndrome, toxic epidermal necrolysis, hepatic necrosis, and serious blood disorders (see Cough, shortness of breath, and pulmonary infiltrates are hypersensitivity reactions of the respiratory tract that have been reported in association with sulfonamide treatment.Sulfamethoxazole/trimethoprim-induced thrombocytopenia may be an immune-mediated disorder. In two studies in rats, no teratology was observed when 512 mg/kg of sulfamethoxazole was used in combination with 128 mg/kg of trimethoprim. Use Bactrim DS (sulfamethoxazole and trimethoprim tablets) as ordered by your doctor. Trimethoprim-induced hyperkalemia: An analysis of reported cases. The “gasping syndrome” is characterized by When prescribing BACTRIM in pediatric patients (two months of age and older), consider the combined daily metabolic load of benzyl alcohol from all sources including BACTRIM (contains 10 mg of benzyl alcohol per mL) and other drugs containing benzyl alcohol.The minimum amount of benzyl alcohol at which serious adverse reactions may occur is not known [see Treatment failure and excess mortality were observed when BACTRIM was used concomitantly with Avoid use of BACTRIM in patients with impaired renal or hepatic function, in those with possible Local irritation and inflammation due to extravascular infiltration of the infusion have been observed with BACTRIM. Excretion of trimethoprim and sulfamethoxazole is primarily by the kidneys through both The pharmacokinetics of sulfamethoxazole 800 mg and trimethoprim 160 mg were studied in six geriatric subjects (mean age: 78.6 years) and six young healthy subjects (mean age: 29.3 years) using a non-US approved formulation. Discontinue BACTRIM if a significant reduction in the count of any formed blood element is noted. Bowel regularity means a bowel movement every day. If these occur the infusion should be discontinued and restarted at another site.Trimethoprim, component of BACTRIM, has been noted to impair Like other drugs containing sulfonamides, BACTRIM can precipitate Avoid coadministration of BACTRIM and leucovorin during treatment of High dosage of trimethoprim, as used in patients with During treatment, ensure adequate fluid intake and urinary output to prevent crystalluria. Available for Android and iOS devices. BACTRIM™ (trimethoprim and sulfamethoxazole) injection, a sterile solution for intravenous infusion only, is a combination of sulfamethoxazole, a sulfonamide antimicrobial, and trimethoprim, a dihydrofolate reductase inhibitor antibacterial. Antibiotic prescribing for AS was associated with lower odds of subsequent brain abscess (OR 0.12; 95% CI = 0.02 to 0.70); NNT to prevent one case was 19 988 (95% CI = 4951 to 167 099).