Do not take a double dose to make up for a forgotten tablet.For the 7, 14, 28 and 84 tablets pack sizes, you can check the day on which you last took a tablet of Clopidogrel Zentiva by referring to the calendar printed on the blister.If you have any further questions on the use of this medicine, ask your doctor or pharmacist.Like all medicines, this medicine can cause side effects, although not everybody gets them.If you experience prolonged bleeding when taking Clopidogrel ZentivaIf you cut or injure yourself, it may take longer than usual for bleeding to stop. In any case it is extremely important not to stop clopidogrel after a stent - even for a few days - until your cardiologist tells you to. In ST-segment-elevation myocardial infarction, fewer patients on Clopidogrel Zentiva had events than patients on placebo (262 against 377 in the CLARITY study, and 2,121 against 2,310 in the COMMIT study).

This showed that Clopidogrel Zentiva reduces the risk of an event.In the study in atrial-fibrillation patients, Clopidogrel Zentiva taken together with aspirin reduced the risk of new events by 11% compared with placebo taken with aspirin, with the largest reduction (28%) seen for stroke.The most common side effects with Clopidogrel Zentiva (seen in between 1 and 10 patients in 100) are haematoma (a collection of blood under the skin), epistaxis (nosebleeds), gastrointestinal haemorrhage (bleeding in the stomach or gut), diarrhoea, abdominal pain (stomach ache), dyspepsia (heartburn), bruising and bleeding where the skin is punctured. (PDF/96.36 KB) The patients were treated for an average of three years, and the main measure of effectiveness was the number of patients who experienced an ‘event’ such as a heart attack, ischaemic stroke or death.Clopidogrel Zentiva was more effective than aspirin at preventing new ischaemic events. Clopidogrel, sold under the trade name Plavix among others, is an antiplatelet medication used to reduce the risk of heart disease and stroke in those at high risk. About clopidogrel. (PDF/408.98 KB) This medicinal product contains hydrogenated castor oil which may cause stomach upset and diarrhoea. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. By preventing this clumping, antiplatelet medicinal products reduce the chances of blood clots forming (a process called thrombosis).Clopidogrel Zentiva is taken by adults to prevent blood clots (thrombi) forming in hardened blood vessels (arteries), a process known as atherothrombosis, which can lead to atherothrombotic events (such as stroke, heart attack, or death).You have been prescribed Clopidogrel Zentiva to help prevent blood clots and reduce the risk of these severe events because:2. (PDF/531.16 KB) In acute coronary syndrome and atrial fibrillation, Clopidogrel Zentiva is used together with aspirin, the dose of which should not be higher than 100 mg.Clopidogrel Zentiva is converted into its active form in the body. Clopidogrel Zentiva keeps the platelets in your blood from coagulating to prevent unwanted blood clots that can occur with certain heart or blood vessel conditions.

Clopidogrel stops the platelets aggregating by blocking a substance called ADP from attaching to a special receptor on their surface.

(PDF/477.91 KB) (PDF/124.83 KB) When the blood clots, this is due to special cells in the blood called platelets aggregating (sticking together). (PDF/112.77 KB) Clopidogrel Winthrop has also been compared with placebo in two studies involving patients with ST-segment elevation: CLARITY, which involved over 3,000 patients and lasted for up to eight days; and COMMIT, which involved almost 46,000 patients and in which the patients received Clopidogrel Winthrop with or without metoprolol (another medicine used for heart problems or high blood pressure) for up to four weeks. Clopidogrel Winthrop has also been compared with placebo in two studies involving patients with ST-segment elevation: CLARITY, which involved over 3,000 patients and lasted for up to eight days; and COMMIT, which involved almost 46,000 patients and in which the patients received Clopidogrel Winthrop with or without metoprolol (another medicine used for heart problems or high blood pressure) for up to four weeks. These measures will help to protect the environment.The active substance is clopidogrel. (PDF/16.69 KB) In other words, about 10 patients in 1,000 will avoid having a new ischaemic event two years after starting Clopidogrel Zentiva instead of aspirin.In non-ST-segment-elevation acute coronary syndrome, the overall relative reduction in the risk of an event compared with placebo was 20%.
(PDF/22.39 KB) (PDF/91.58 KB) Clopidogrel Zentiva keeps the platelets in your blood from coagulating to prevent unwanted blood clots that can occur with certain heart or blood vessel conditions. You can also report side effects directly via the national reporting system listed below.Yellow Card Scheme at: www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App StoreBy reporting side effects you can help provide more information on the safety of this medicine.Keep this medicine out of the sight and reach of children.Do not use this medicine after the expiry date which is stated on the carton and on the blister, after EXP. (PDF/128.83 KB) (PDF/508.81 KB)
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