Furthermore, it has been suggested that statins may have a role in the primary prevention of rheumatoid arthritis, but so far there has been no solid … Clipboard, Search History, and several other advanced features are temporarily unavailable. In the OA analysis, a 10% increase in PDC was related with an adjusted HR of 0.99 (95% CI 0.99–1.00) for OA. 2012 Aug;21(8):835-43. doi: 10.1002/pds.3291. Results: The cohort included 528,654 new users of statins, with 1,357 new cases of RA occurring during a mean follow-up of 3.3 years, for an incidence rate of 7.9 per 10,000 person-years.Cases were more likely to be smokers, to have other autoimmune diseases and to have had lower total cholesterol levels at baseline. The authors report that no funding was required for the study, which was published in There are some potentially misleading points in the news articles. The results of the JUPITER trial indicated that statin therapy may also reduce all cause mortality in patients with low LDL cholesterol, probably by decreased inflammation The strengths of the current study include prospective data collection, the use of administrative databases to avoid the problem of differential recall bias, the systematic and comprehensive collection of personal sociodemographic data, medical history, and utilization of health services prior to the index date, which reduces the possibility for bias due to study outcomes. Unable to load your collection due to an error An important shortcoming is its failure to take into account some medical and lifestyle factors that could have influenced its results. Cholesterol-lowering statin drugs may also reduce the risk of developing rheumatoid arthritis by over 40%, the The news is based on a large Israeli study, which looked at how the regularity of patients’ use of statins related to their chances of developing the painful joint problem.

However, a majority of RA patients (79%) purchased statins at least 3 mo prior to diagnosis.
Rheumatoid arthritis is a disease characterized by chronic inflammation. We only included patients who were enrolled in MHS and did not have a statin prescription at least 3 y prior to the index date. Unable to load your delegates due to an error researchers from Tel Aviv University and other medical and academic centres in Israel Controlled trials are now necessary to establish whether statins do reduce the risk of arthritis.People who have not been recommended or prescribed statins should not take them to attempt to prevent rheumatoid arthritis. 2009 Apr;68(4):546-51. doi: 10.1136/ard.2008.091967. PLOS is a nonprofit 501(c)(3) corporation, #C2354500, based in San Francisco, California, US I wondered if is is possible the Statin drugs do inhibit the work of arthritis meds? There is some evidence that statins may have anti-inflammatory and immunumodulatory properties, demonstrated by reducing the level of C-reactive protein that may play an important role in chronic inflammatory diseases, such as rheumatoid arthritis—a chronic condition … Persistence with statins was assessed by calculating the mean proportion of follow-up days covered (PDC) with statins for every study participant. There is some evidence that statins may have anti-inflammatory and immunumodulatory properties, demonstrated by reducing the level of C-reactive protein that may play an important role in chronic inflammatory diseases, such as rheumatoid arthritis—a chronic condition that is a major cause of disability. Some small studies have suggested a modest effect of statins in decreasing disease activity in patients with rheumatoid arthritis, but a recent larger study involving over 30,000 patients with rheumatoid arthritis showed no beneficial effect. However, the observed associations were greater than those that would be expected from methodological biases alone. These mechanisms may elucidate the improved, yet modest overall, RA disease activity, swollen joint scores, and reduced CRP in the TARA (Trial of Atorvastatin in Rheumatoid Arthritis) trial, a 6-mo, placebo-controlled, randomized clinical trial with Atorvastatin The JUPITER (Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin) trial was designed to investigate the preventive effects of Rosuvastatin against vascular events among individuals with LDL cholesterol <130 mg/dl and enhanced innate immune response, as determined by a high-sensitivity CRP (hsCRP) level. It should be noted that the study compared the incidence of rheumatoid arthritis in people taking different amounts of statins, but did not assess arthritis risk in people who did not use statins. Laboratory test results included liver function and the median of all low-density lipoprotein (LDL)-cholesterol tests during the year prior to the index date, as well as presence of rheumatoid factor (RF) in patients diagnosed with RA.A chi-square test for categorical variables and a Kruskal-Wallis test for continuous variables were performed to determine significant differences in baseline characteristics and levels of PDC with statins that were categorized into <20% (reference category), 20%–39%, 40%–59%, 60%–79%, and 80% or above. The study analysed data on 211,627 people in the rheumatoid arthritis calculations and 193,770 in the osteoarthritis calculations.The researchers recruited adults aged over 18 who registered with a particular Israeli health insurance organisation between 1995 and 1998. According to the most recent report of the Israel National Insurance Incident cases of RA were defined by the date of first diagnostic codes associated with RA (Rheumatoid arthritis; International Classification of Diseases, 9th revision [ICD-9] codes 714.x) during the study follow-up period. Evidence suggests that a popular class of cholesterol treatment drugs, called statins, slightly change immune functions and may have a beneficial effect on patients with rheumatoid arthritis. The present retrospective cohort is one of the largest undertaken to date on the relationship between statin therapy and RA, with respect to the length of follow-up and the size of the study population.

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