Metoprolol tartrate has been shown to increase post-implantation loss and decrease neonatal survival in rats at doses up to 22 times, on a mg/mThe use of thiazide diuretics in pregnant women requires that the anticipated benefit be weighed against possible hazards to the fetus. In the presence of AV block, beta-blockade may prevent the necessary facilitating effect of sympathetic activity on conduction. This product is available in the following dosage forms: Gu et al . Be ready to tell or show what was GENERIC NAME: METOPROLOL/HYDROCHLOROTHIAZIDE - ORAL (met-oh-PRO-lol/HYE-droe-KLOR-oh-THYE-a-zide) BRAND NAME(S): Lopressor HCT Warning | Medication Uses | How To Use | Side Effects | Precautions | Drug Interactions | Overdose | Notes | Missed Dose | Storage
This product contains 2 medications, metoprolol and hydrochlorothiazide. Thiazides affect the renal tubular mechanisms of electrolyte reabsorption, directly increasing excretion of sodium and chloride in approximately equimolar amounts. WARNING: CARDIAC ISCHEMIA AFTER ABRUPT DISCONTINUATIONFollowing abrupt discontinuation of therapy with beta adrenergic blockers, exacerbations of angina pectoris and myocardial infarction have occurred.When discontinuing chronically administered Metoprolol Succinate Extended Release/Hydrochlorothiazide, particularly in patients with ischemic heart disease, gradually reduce the dose over a period of 1–2 weeks and monitor the patient. If justified, gastric lavage and/or activated charcoal can be administered.Based on the expected pharmacologic actions and recommendations for other beta adrenergic blockers and hydrochlorothiazide, the following measures should be considered when clinically warranted.Metoprolol Succinate Extended Release/Hydrochlorothiazide combines a beta adrenoceptor blocker and a thiazide diuretic.Metoprolol succinate is chemically described as (±)1-(isopropylamino)-3-[p-(2-methoxyethyl) phenoxy]-2-propanol succinate (2:1) (salt). Advertising revenue supports our not-for-profit mission.Check out these best-sellers and special offers on books and newsletters from Mayo Clinic. COMMON BRAND(S): Lopressor HCT. Following oral administration, plasma hydrochlorothiazide concentrations decline bi-exponentially, with a mean distribution half-life of about 2 hours and an elimination half-life of about 10 hours.About 70% of an orally administered dose of hydrochlorothiazide is eliminated in the urine as unchanged drug.Carcinogenicity and mutagenicity studies have not been conducted with combinations of Metoprolol and Hydrochlorothiazide.A combination of metoprolol tartrate and hydrochlorothiazide produced no adverse effects on the fertility and reproductive performance of male and female rats at doses of up to 200/50 mg/kg/day [about 10 and 20 times the maximum recommended human dose (MRHD) of Metoprolol and Hydrochlorothiazide, respectively, on a mg/mLong-term studies in animals have been conducted to evaluate the carcinogenic potential of metoprolol tartrate. Patients with bronchospastic disease should, in general, not receive beta adrenergic blockers. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. This product is available in the following dosage forms:Portions of this document last updated: Aug. 01, 2020Copyright © 2020 IBM Watson Health. The blood pressure lowering effect 24 hours post-dosing retained approximately 96% of the peak effect (6 hours post-dosing). The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of particular drug is safe, appropriate or effective for you or anyone else. All rights reserved. If angina markedly worsens or acute coronary ischemia develops, promptly resume therapy and take measures appropriate for the management of unstable angina. Symptoms include acute onset of decreased visual acuity or ocular pain and typically occur within hours to weeks of hydrochlorothiazide initiation. The most prominent feature of overdose is acute loss of fluid, electrolytes and magnesium. Select one or more newsletters to continue. Warn patients against interruption or discontinuation of therapy without the physician’s advice.Because coronary artery disease is common and may be unrecognized, avoid abrupt discontinuation of Metoprolol Succinate Extended Release/Hydrochlorothiazide therapy even in patients treated only for hypertension Metoprolol succinate extended release/hydrochlorothiazidemetoprolol succinate and hydrochlorothiazide tabletmetoprolol succinate and hydrochlorothiazide tabletmetoprolol succinate and hydrochlorothiazide tabletWe comply with the HONcode standard for trustworthy health information -
Metoprolol SUCCINATE ER-HCTZ.

In addition, patients 70 to 84 years of age were studied in two clinical outcome trials (n=3025), which included a treatment regimen of a thiazide diuretic or beta adrenergic blocker (metoprolol succinate extended release, atenolol or pindolol) or their combination have not identified differences in responses between the elderly and younger patients.Hydrochlorothiazide is known to be substantially excreted by the kidney, and the risk of toxic reactions to this drug may be greater in patients with impaired renal function.Minor alterations of fluid and electrolyte balance may precipitate hepatic coma in patients with impaired hepatic function or progressive liver disease.Safety and effectiveness of Metoprolol Succinate Extended Release/Hydrochlorothiazide in patients with severe renal impairment (CrCL≤30 ml/min) have not been established. Metoprolol Succinate Extended Release/Hydrochlorothiazide 100/12.5 contains 95 mg of metoprolol succinate extended release, equivalent to 100 mg of metoprolol tartrate, and 12.5 mg of hydrochlorothiazide. hypokalemia, hypomagnesaemia, hyponatremia, hypochloremia, alkalosis, increased BUN).Care should be provided at a facility that can provide appropriate supporting measures, monitoring and supervision as treatment is symptomatic and supportive and there is no specific antidote.